Cdc48 regulates a deubiquitylase cascade critical for mitochondrial fusion

por Simões, Tânia, Schuster, Ramona, den Brave, Fabian, Escobar-Henriques, Mafalda
Publicado 2018

Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response

por Krakowiak, Joanna, Zheng, Xu, Patel, Nikit, Feder, Zoë A, Anandhakumar, Jayamani, Valerius, Kendra, Gross, David S, Khalil, Ahmad S, Pincus, David
Publicado 2018

COX16 promotes COX2 metallation and assembly during respiratory complex IV biogenesis

por Aich, Abhishek, Wang, Cong, Chowdhury, Arpita, Ronsör, Christin, Pacheu-Grau, David, Richter-Dennerlein, Ricarda, Dennerlein, Sven, Rehling, Peter
Publicado 2018

Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system

por Yang, Xi, Arines, Felichi Mae, Zhang, Weichao, Li, Ming
Publicado 2018

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis

por Galic, Sandra, Loh, Kim, Murray-Segal, Lisa, Steinberg, Gregory R, Andrews, Zane B, Kemp, Bruce E
Publicado 2018

Crk proteins transduce FGF signaling to promote lens fiber cell elongation

por Collins, Tamica N, Mao, Yingyu, Li, Hongge, Bouaziz, Michael, Hong, Angela, Feng, Gen-Sheng, Wang, Fen, Quilliam, Lawrence A, Chen, Lin, Park, Taeju, Curran, Tom, Zhang, Xin
Publicado 2018

Translational control of ERK signaling through miRNA/4EHP-directed silencing

por Jafarnejad, Seyed Mehdi, Chapat, Clément, Matta-Camacho, Edna, Gelbart, Idit Anna, Hesketh, Geoffrey G, Arguello, Meztli, Garzia, Aitor, Kim, Sung-Hoon, Attig, Jan, Shapiro, Maayan, Morita, Masahiro, Khoutorsky, Arkady, Alain, Tommy, Gkogkas, Christos, G, Stern-Ginossar, Noam, Tuschl, Thomas, Gingras, Anne-Claude, Duchaine, Thomas F, Sonenberg, Nahum
Publicado 2018

Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function

por Feng, Suihan, Harayama, Takeshi, Montessuit, Sylvie, David, Fabrice PA, Winssinger, Nicolas, Martinou, Jean-Claude, Riezman, Howard
Publicado 2018

3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound

por Brignole, Edward J, Tsai, Kuang-Lei, Chittuluru, Johnathan, Li, Haoran, Aye, Yimon, Penczek, Pawel A, Stubbe, JoAnne, Drennan, Catherine L, Asturias, Francisco
Publicado 2018

Dissection of affinity captured LINE-1 macromolecular complexes

por Taylor, Martin S, Altukhov, Ilya, Molloy, Kelly R, Mita, Paolo, Jiang, Hua, Adney, Emily M, Wudzinska, Aleksandra, Badri, Sana, Ischenko, Dmitry, Eng, George, Burns, Kathleen H, Fenyö, David, Chait, Brian T, Alexeev, Dmitry, Rout, Michael P, Boeke, Jef D, LaCava, John
Publicado 2018

Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice

por Ghosh, Shrestha, Wong, Sheung Kin, Jiang, Zhixin, Liu, Baohua, Wang, Yi, Hao, Quan, Gorbunova, Vera, Liu, Xinguang, Zhou, Zhongjun
Publicado 2018

NRF2 regulates core and stabilizing circadian clock loops, coupling redox and timekeeping in Mus musculus

por Wible, Ryan S, Ramanathan, Chidambaram, Sutter, Carrie Hayes, Olesen, Kristin M, Kensler, Thomas W, Liu, Andrew C, Sutter, Thomas R
Publicado 2018

The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes

por Wong, Yao Liang, LeBon, Lauren, Edalji, Rohinton, Lim, Hock Ben, Sun, Chaohong, Sidrauski, Carmela
Publicado 2018

Explosive mutation accumulation triggered by heterozygous human Pol ε proofreading-deficiency is driven by suppression of mismatch repair

por Hodel, Karl P, de Borja, Richard, Henninger, Erin E, Campbell, Brittany B, Ungerleider, Nathan, Light, Nicholas, Wu, Tong, LeCompte, Kimberly G, Goksenin, A Yasemin, Bunnell, Bruce A, Tabori, Uri, Shlien, Adam, Pursell, Zachary F
Publicado 2018

TGF-β uses a novel mode of receptor activation to phosphorylate SMAD1/5 and induce epithelial-to-mesenchymal transition

por Ramachandran, Anassuya, Vizán, Pedro, Das, Debipriya, Chakravarty, Probir, Vogt, Janis, Rogers, Katherine W, Müller, Patrick, Hinck, Andrew P, Sapkota, Gopal P, Hill, Caroline S
Publicado 2018

Serine is the major residue for ADP-ribosylation upon DNA damage

por Palazzo, Luca, Leidecker, Orsolya, Prokhorova, Evgeniia, Dauben, Helen, Matic, Ivan, Ahel, Ivan
Publicado 2018

Neutrophil-generated HOCl leads to non-specific thiol oxidation in phagocytized bacteria

por Degrossoli, Adriana, Müller, Alexandra, Xie, Kaibo, Schneider, Jannis F, Bader, Verian, Winklhofer, Konstanze F, Meyer, Andreas J, Leichert, Lars I
Publicado 2018

Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility

por Zhang, Dao-Lai, Sun, Yu-Jing, Ma, Ming-Liang, Wang, Yi-jing, Lin, Hui, Li, Rui-Rui, Liang, Zong-Lai, Gao, Yuan, Yang, Zhao, He, Dong-Fang, Lin, Amy, Mo, Hui, Lu, Yu-Jing, Li, Meng-Jing, Kong, Wei, Chung, Ka Young, Yi, Fan, Li, Jian-Yuan, Qin, Ying-Ying, Li, Jingxin, Thomsen, Alex R B, Kahsai, Alem W, Chen, Zi-Jiang, Xu, Zhi-Gang, Liu, Mingyao, Li, Dali, Yu, Xiao, Sun, Jin-Peng
Publicado 2018

Molecular mechanism to target the endosomal Mon1-Ccz1 GEF complex to the pre-autophagosomal structure

por Gao, Jieqiong, Langemeyer, Lars, Kümmel, Daniel, Reggiori, Fulvio, Ungermann, Christian
Publicado 2018

Allosteric mechanism of the V. vulnificus adenine riboswitch resolved by four-dimensional chemical mapping

por Tian, Siqi, Kladwang, Wipapat, Das, Rhiju
Publicado 2018