2,5-Hexanedione mediates neuronal apoptosis through suppression of NGF via PI3K/Akt signaling in the rat sciatic nerve

por Zuo, Enjun, Zhang, Cong, Mao, Jun, Gao, Chenxue, Hu, Shuhai, Shi, Xiaoxia, Piao, Fengyuan
Publicado 2019

Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

por Naito, Tomoki, Ercan, Bilge, Krshnan, Logesvaran, Triebl, Alexander, Koh, Dylan Hong Zheng, Wei, Fan-Yan, Tomizawa, Kazuhito, Torta, Federico Tesio, Wenk, Markus R, Saheki, Yasunori
Publicado 2019

Uncovering the secret life of Rho GTPases

por Perry, Jenna A, Maddox, Amy Shaub
Publicado 2019

Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases

por Golding, Adriana E, Visco, Ilaria, Bieling, Peter, Bement, William M
Publicado 2019

Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation

por Greene, Eric R, Goodall, Ellen A, de la Peña, Andres H, Matyskiela, Mary E, Lander, Gabriel C, Martin, Andreas
Publicado 2019

Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1

por Peterson, Brian G, Glaser, Morgan L, Rapoport, Tom A, Baldridge, Ryan D
Publicado 2019

Long-lived metabolic enzymes in the crystalline lens identified by pulse-labeling of mice and mass spectrometry

por Liu, Pan, Edassery, Seby Louis, Ali, Laith, Thomson, Benjamin R, Savas, Jeffrey N, Jin, Jing
Publicado 2019

Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

por Nehammer, Camilla, Ejlerskov, Patrick, Gopal, Sandeep, Handley, Ava, Ng, Leelee, Moreira, Pedro, Lee, Huikyong, Issazadeh-Navikas, Shohreh, Rubinsztein, David C, Pocock, Roger
Publicado 2019

Mechanistic basis of the inhibition of SLC11/NRAMP-mediated metal ion transport by bis-isothiourea substituted compounds

por Manatschal, Cristina, Pujol-Giménez, Jonai, Poirier, Marion, Reymond, Jean-Louis, Hediger, Matthias A, Dutzler, Raimund
Publicado 2019

A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion

por Cai, Xiao-Chuan, Zhang, Tuo, Kim, Eui-jun, Jiang, Ming, Wang, Ke, Wang, Junyi, Chen, Shi, Zhang, Nawei, Wu, Hong, Li, Fengling, dela Seña, Carlo C, Zeng, Hong, Vivcharuk, Victor, Niu, Xiang, Zheng, Weihong, Lee, Jonghan P, Chen, Yuling, Barsyte, Dalia, Szewczyk, Magda, Hajian, Taraneh, Ibáñez, Glorymar, Dong, Aiping, Dombrovski, Ludmila, Zhang, Zhenyu, Deng, Haiteng, Min, Jinrong, Arrowsmith, Cheryl H, Mazutis, Linas, Shi, Lei, Vedadi, Masoud, Brown, Peter J, Xiang, Jenny, Qin, Li-Xuan, Xu, Wei, Luo, Minkui
Publicado 2019

Modulating FOXO3 transcriptional activity by small, DBD-binding molecules

por Hagenbuchner, Judith, Obsilova, Veronika, Kaserer, Teresa, Kaiser, Nora, Rass, Bettina, Psenakova, Katarina, Docekal, Vojtech, Alblova, Miroslava, Kohoutova, Klara, Schuster, Daniela, Aneichyk, Tatsiana, Vesely, Jan, Obexer, Petra, Obsil, Tomas, Ausserlechner, Michael J
Publicado 2019

Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

por Kitakaze, Keisuke, Taniuchi, Shusuke, Kawano, Eri, Hamada, Yoshimasa, Miyake, Masato, Oyadomari, Miho, Kojima, Hirotatsu, Kosako, Hidetaka, Kuribara, Tomoko, Yoshida, Suguru, Hosoya, Takamitsu, Oyadomari, Seiichi
Publicado 2019

Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling

por Huis in 't Veld, Pim J, Volkov, Vladimir A, Stender, Isabelle D, Musacchio, Andrea, Dogterom, Marileen
Publicado 2019

Subcellular drug targeting illuminates local kinase action

por Bucko, Paula J, Lombard, Chloe K, Rathbun, Lindsay, Garcia, Irvin, Bhat, Akansha, Wordeman, Linda, Smith, F Donelson, Maly, Dustin J, Hehnly, Heidi, Scott, John D
Publicado 2019

The Ormdl genes regulate the sphingolipid synthesis pathway to ensure proper myelination and neurologic function in mice

por Clarke, Benjamin A, Majumder, Saurav, Zhu, Hongling, Lee, Y Terry, Kono, Mari, Li, Cuiling, Khanna, Caroline, Blain, Hailey, Schwartz, Ronit, Huso, Vienna L, Byrnes, Colleen, Tuymetova, Galina, Dunn, Teresa M, Allende, Maria L, Proia, Richard L
Publicado 2019

Exchange of water for sterol underlies sterol egress from a StARkin domain

por Khelashvili, George, Chauhan, Neha, Pandey, Kalpana, Eliezer, David, Menon, Anant K
Publicado 2019

C-mannosylation supports folding and enhances stability of thrombospondin repeats

por Shcherbakova, Aleksandra, Preller, Matthias, Taft, Manuel H, Pujols, Jordi, Ventura, Salvador, Tiemann, Birgit, Buettner, Falk FR, Bakker, Hans
Publicado 2019

Biochemical reconstitution of branching microtubule nucleation

por Alfaro-Aco, Raymundo, Thawani, Akanksha, Petry, Sabine
Publicado 2020

Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations

por Shen, Birong, Chapman, Joseph H, Custance, Michael F, Tricola, Gianna M, Jones, Charles E, Furano, Anthony V
Publicado 2020

The GTPase Nog1 co-ordinates the assembly, maturation and quality control of distant ribosomal functional centers

por Klingauf-Nerurkar, Purnima, Gillet, Ludovic C, Portugal-Calisto, Daniela, Oborská-Oplová, Michaela, Jäger, Martin, Schubert, Olga T, Pisano, Agnese, Peña, Cohue, Rao, Sanjana, Altvater, Martin, Chang, Yiming, Aebersold, Ruedi, Panse, Vikram G
Publicado 2020