Guanidine hydrochloride reactivates an ancient septin hetero-oligomer assembly pathway in budding yeast

por Johnson, Courtney R, Steingesser, Marc G, Weems, Andrew D, Khan, Anum, Gladfelter, Amy, Bertin, Aurélie, McMurray, Michael A
Publicado 2020

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

por Fribourgh, Jennifer L, Srivastava, Ashutosh, Sandate, Colby R, Michael, Alicia K, Hsu, Peter L, Rakers, Christin, Nguyen, Leslee T, Torgrimson, Megan R, Parico, Gian Carlo G, Tripathi, Sarvind, Zheng, Ning, Lander, Gabriel C, Hirota, Tsuyoshi, Tama, Florence, Partch, Carrie L
Publicado 2020

Fatal amyloid formation in a patient’s antibody light chain is caused by a single point mutation

por Kazman, Pamina, Vielberg, Marie-Theres, Pulido Cendales, María Daniela, Hunziger, Lioba, Weber, Benedikt, Hegenbart, Ute, Zacharias, Martin, Köhler, Rolf, Schönland, Stefan, Groll, Michael, Buchner, Johannes
Publicado 2020

Homologue replacement in the import motor of the mitochondrial inner membrane of trypanosomes

por von Känel, Corinne, Muñoz-Gómez, Sergio A, Oeljeklaus, Silke, Wenger, Christoph, Warscheid, Bettina, Wideman, Jeremy G, Harsman, Anke, Schneider, Andre
Publicado 2020

JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes

por Lee, Schuyler, Liu, Haolin, Hill, Ryan, Chen, Chunjing, Hong, Xia, Crawford, Fran, Kingsley, Molly, Zhang, Qianqian, Liu, Xinjian, Chen, Zhongzhou, Lengeling, Andreas, Bernt, Kathrin Maria, Marrack, Philippa, Kappler, John, Zhou, Qiang, Li, Chuan-Yuan, Xue, Yuhua, Hansen, Kirk, Zhang, Gongyi
Publicado 2020

Adaptation of hydroxymethylbutenyl diphosphate reductase enables volatile isoprenoid production

por Bongers, Mareike, Perez-Gil, Jordi, Hodson, Mark P, Schrübbers, Lars, Wulff, Tune, Sommer, Morten OA, Nielsen, Lars K, Vickers, Claudia E
Publicado 2020

Organic electrochemical transistor arrays for real-time mapping of evoked neurotransmitter release in vivo

por Xie, Kai, Wang, Naixiang, Lin, Xudong, Wang, Zixun, Zhao, Xi, Fang, Peilin, Yue, Haibing, Kim, Junhwi, Luo, Jing, Cui, Shaoyang, Yan, Feng, Shi, Peng
Publicado 2020

RNA-guided retargeting of Sleeping Beauty transposition in human cells

por Kovač, Adrian, Miskey, Csaba, Menzel, Michael, Grueso, Esther, Gogol-Döring, Andreas, Ivics, Zoltán
Publicado 2020

Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme

por Backman, Lindsey RF, Huang, Yolanda Y, Andorfer, Mary C, Gold, Brian, Raines, Ronald T, Balskus, Emily P, Drennan, Catherine L
Publicado 2020

Mitochondrial ClpX activates an essential biosynthetic enzyme through partial unfolding

por Kardon, Julia R, Moroco, Jamie A, Engen, John R, Baker, Tania A
Publicado 2020

Chemoptogenetic ablation of neuronal mitochondria in vivo with spatiotemporal precision and controllable severity

por Xie, Wenting, Jiao, Binxuan, Bai, Qing, Ilin, Vladimir A, Sun, Ming, Burton, Charles E, Kolodieznyi, Dmytro, Calderon, Michael J, Stolz, Donna B, Opresko, Patricia L, St Croix, Claudette M, Watkins, Simon, Van Houten, Bennett, Bruchez, Marcel P, Burton, Edward A
Publicado 2020

Structure-based discovery of potent and selective melatonin receptor agonists

por Patel, Nilkanth, Huang, Xi Ping, Grandner, Jessica M, Johansson, Linda C, Stauch, Benjamin, McCorvy, John D, Liu, Yongfeng, Roth, Bryan, Katritch, Vsevolod
Publicado 2020

The guide sRNA sequence determines the activity level of box C/D RNPs

por Graziadei, Andrea, Gabel, Frank, Kirkpatrick, John, Carlomagno, Teresa
Publicado 2020

A dynamic charge-charge interaction modulates PP2A:B56 substrate recruitment

por Wang, Xinru, Garvanska, Dimitriya H, Nasa, Isha, Ueki, Yumi, Zhang, Gang, Kettenbach, Arminja N, Peti, Wolfgang, Nilsson, Jakob, Page, Rebecca
Publicado 2020

Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function

por Gerndt, Susanne, Chen, Cheng-Chang, Chao, Yu-Kai, Yuan, Yu, Burgstaller, Sandra, Scotto Rosato, Anna, Krogsaeter, Einar, Urban, Nicole, Jacob, Katharina, Nguyen, Ong Nam Phuong, Miller, Meghan T, Keller, Marco, Vollmar, Angelika M, Gudermann, Thomas, Zierler, Susanna, Schredelseker, Johann, Schaefer, Michael, Biel, Martin, Malli, Roland, Wahl-Schott, Christian, Bracher, Franz, Patel, Sandip, Grimm, Christian
Publicado 2020

A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

por Sagert, Lina, Hennig, Felix, Thomas, Christoph, Tampé, Robert
Publicado 2020

Targeting mir128-3p alleviates myocardial insulin resistance and prevents ischemia-induced heart failure

por Ruiz-Velasco, Andrea, Zi, Min, Hille, Susanne S, Azam, Tayyiba, Kaur, Namrita, Jiang, Juwei, Nguyen, Binh, Sekeres, Karolina, Binder, Pablo, Collins, Lucy, Pu, Fay, Xiao, Han, Guan, Kaomei, Frey, Norbert, Cartwright, Elizabeth J, Müller, Oliver J, Wang, Xin, Liu, Wei
Publicado 2020

Nicotinamide mononucleotide adenylyltransferase uses its NAD(+) substrate-binding site to chaperone phosphorylated Tau

por Ma, Xiaojuan, Zhu, Yi, Lu, Jinxia, Xie, Jingfei, Li, Chong, Shin, Woo Shik, Qiang, Jiali, Liu, Jiaqi, Dou, Shuai, Xiao, Yi, Wang, Chuchu, Jia, Chunyu, Long, Houfang, Yang, Juntao, Fang, Yanshan, Jiang, Lin, Zhang, Yaoyang, Zhang, Shengnan, Zhai, Rong Grace, Liu, Cong, Li, Dan
Publicado 2020

Lipid polarity gradient formed by ω-hydroxy lipids in tear film prevents dry eye disease

por Miyamoto, Masatoshi, Sassa, Takayuki, Sawai, Megumi, Kihara, Akio
Publicado 2020

Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation

por Bhattacharyya, Moitrayee, Lee, Young Kwang, Muratcioglu, Serena, Qiu, Baiyu, Nyayapati, Priya, Schulman, Howard, Groves, Jay T, Kuriyan, John
Publicado 2020