Structures reveal gatekeeping of the mitochondrial Ca(2+) uniporter by MICU1-MICU2

por Wang, Chongyuan, Jacewicz, Agata, Delgado, Bryce D, Baradaran, Rozbeh, Long, Stephen Barstow
Publicado 2020

The structural determinants of PH domain-mediated regulation of Akt revealed by segmental labeling

por Chu, Nam, Viennet, Thibault, Bae, Hwan, Salguero, Antonieta, Boeszoermenyi, Andras, Arthanari, Haribabu, Cole, Philip A
Publicado 2020

Measuring protein stability in the GroEL chaperonin cage reveals massive destabilization

por Korobko, Ilia, Mazal, Hisham, Haran, Gilad, Horovitz, Amnon
Publicado 2020

Structural insights into the Ca(2+)-dependent gating of the human mitochondrial calcium uniporter

por Wang, Yan, Han, Yan, She, Ji, Nguyen, Nam X, Mootha, Vamsi K, Bai, Xiao-chen, Jiang, Youxing
Publicado 2020

A molecular dual carriageway

por Allen, William J, Collinson, Ian
Publicado 2020

A two-lane mechanism for selective biological ammonium transport

por Williamson, Gordon, Tamburrino, Giulia, Bizior, Adriana, Boeckstaens, Mélanie, Dias Mirandela, Gaëtan, Bage, Marcus G, Pisliakov, Andrei, Ives, Callum M, Terras, Eilidh, Hoskisson, Paul A, Marini, Anna Maria, Zachariae, Ulrich, Javelle, Arnaud
Publicado 2020

The autophagy adaptor NDP52 and the FIP200 coiled-coil allosterically activate ULK1 complex membrane recruitment

por Shi, Xiaoshan, Chang, Chunmei, Yokom, Adam L, Jensen, Liv E, Hurley, James H
Publicado 2020

Atomic structure of a mitochondrial complex I intermediate from vascular plants

por Maldonado, Maria, Padavannil, Abhilash, Zhou, Long, Guo, Fei, Letts, James A
Publicado 2020

Transient intracellular acidification regulates the core transcriptional heat shock response

por Triandafillou, Catherine G, Katanski, Christopher D, Dinner, Aaron R, Drummond, D Allan
Publicado 2020

How to measure and evaluate binding affinities

por Jarmoskaite, Inga, AlSadhan, Ishraq, Vaidyanathan, Pavanapuresan P, Herschlag, Daniel
Publicado 2020

Systemic Treatment With Nicotinamide Riboside Is Protective in a Mouse Model of Light-Induced Retinal Degeneration

por Zhang, Xian, Henneman, Nathaniel F., Girardot, Preston E., Sellers, Jana T., Chrenek, Micah A., Li, Ying, Wang, Jiaxing, Brenner, Charles, Nickerson, John M., Boatright, Jeffrey H.
Publicado 2020

Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation

por Lv, Lu, Chen, Peihao, Cao, Longzhi, Li, Yamei, Zeng, Zhi, Cui, Yue, Wu, Qingcui, Li, Jiaojiao, Wang, Jian-Hua, Dong, Meng-Qiu, Qi, Xiangbing, Han, Ting
Publicado 2020

Chemical and structural investigation of the paroxetine-human serotonin transporter complex

por Coleman, Jonathan A, Navratna, Vikas, Antermite, Daniele, Yang, Dongxue, Bull, James A, Gouaux, Eric
Publicado 2020

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria

por Nowinski, Sara M, Solmonson, Ashley, Rusin, Scott F, Maschek, J Alan, Bensard, Claire L, Fogarty, Sarah, Jeong, Mi-Young, Lettlova, Sandra, Berg, Jordan A, Morgan, Jeffrey T, Ouyang, Yeyun, Naylor, Bradley C, Paulo, Joao A, Funai, Katsuhiko, Cox, James E, Gygi, Steven P, Winge, Dennis R, DeBerardinis, Ralph J, Rutter, Jared
Publicado 2020

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

por Alghamdi, Ali H, Munday, Jane C, Campagnaro, Gustavo Daniel, Gurvic, Dominik, Svensson, Fredrik, Okpara, Chinyere E, Kumar, Arvind, Quintana, Juan, Martin Abril, Maria Esther, Milić, Patrik, Watson, Laura, Paape, Daniel, Settimo, Luca, Dimitriou, Anna, Wielinska, Joanna, Smart, Graeme, Anderson, Laura F, Woodley, Christopher M, Kelly, Siu Pui Ying, Ibrahim, Hasan MS, Hulpia, Fabian, Al-Salabi, Mohammed I, Eze, Anthonius A, Sprenger, Teresa, Teka, Ibrahim A, Gudin, Simon, Weyand, Simone, Field, Mark, Dardonville, Christophe, Tidwell, Richard R, Carrington, Mark, O'Neill, Paul, Boykin, David W, Zachariae, Ulrich, De Koning, Harry P
Publicado 2020

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis

por Panic, Vanja, Pearson, Stephanie, Banks, James, Tippetts, Trevor S, Velasco-Silva, Jesse N, Lee, Sanghoon, Simcox, Judith, Geoghegan, Gisela, Bensard, Claire L, van Ry, Tyler, Holland, Will L, Summers, Scott A, Cox, James, Ducker, Gregory S, Rutter, Jared, Villanueva, Claudio J
Publicado 2020

Underground isoleucine biosynthesis pathways in E. coli

por Cotton, Charles AR, Bernhardsgrütter, Iria, He, Hai, Burgener, Simon, Schulz, Luca, Paczia, Nicole, Dronsella, Beau, Erban, Alexander, Toman, Stepan, Dempfle, Marian, De Maria, Alberto, Kopka, Joachim, Lindner, Steffen N, Erb, Tobias J, Bar-Even, Arren
Publicado 2020

When pH comes to the rescue

por Gonçalves, Davi, Santiago, Alec, Morano, Kevin A
Publicado 2020

EDF1 coordinates cellular responses to ribosome collisions

por Sinha, Niladri K, Ordureau, Alban, Best, Katharina, Saba, James A, Zinshteyn, Boris, Sundaramoorthy, Elayanambi, Fulzele, Amit, Garshott, Danielle M, Denk, Timo, Thoms, Matthias, Paulo, Joao A, Harper, J Wade, Bennett, Eric J, Beckmann, Roland, Green, Rachel
Publicado 2020

Intermittent Hypoxia Promotes Functional Neuroprotection from Retinal Ischemia in Untreated First-Generation Offspring: Proteomic Mechanistic Insights

por Harman, Jarrod C., Guidry, Jessie J., Gidday, Jeffrey M.
Publicado 2020