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29401por Plotka, Magdalena, Kapusta, Malgorzata, Dorawa, Sebastian, Kaczorowska, Anna-Karina, Kaczorowski, Tadeusz“…Many of these heat-stable proteins are useful for biotechnological applications; nevertheless, none have been utilized as antibacterial agents. …”
Publicado 2019
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29402por López-Galiano, María José, García-Robles, Inmaculada, González-Hernández, Ana I., Camañes, Gemma, Vicedo, Begonya, Real, M. Dolores, Rausell, Carolina“…Among them, gene expression reprogramming by microRNAs (miRNAs) might offer a biotechnologically sound strategy. Drought-responsive miRNAs have been reported in many plant species, and some of them are known to participate in complex regulatory networks via their regulation of transcription factors involved in water stress signaling. …”
Publicado 2019
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29403por Brand, Guilherme D., Ramada, Marcelo H. S., Manickchand, Júlia R., Correa, Rafael, Ribeiro, Dalila J. S., Santos, Michele A., Vasconcelos, Andreanne G., Abrão, Fernando Y., Prates, Maura V., Murad, André M., Cardozo Fh, José L., Leite, José Roberto S. A., Magalhães, Kelly G., Oliveira, Aline L., Bloch, Carlos“…Our work exemplifies how the human genome can be mined for molecules with biotechnological potential in human health and demonstrates that IAPs are actual alternatives to antimicrobial peptides as pharmaceutical agents or in their many other putative applications.…”
Publicado 2019
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29404por Pomes, Leda Marina, Guglielmetti, Martina, Bertamino, Enrico, Simmaco, Maurizio, Borro, Marina, Martelletti, Paolo“…Novel therapeutic perspectives in migraine includes biotechnological drugs directed against molecules (such as CGRP and its receptor) that cause vasodilatation at the peripheral level of the meningeal blood vessels and reflex stimulation of the parasympathetic system. …”
Publicado 2019
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29405por Li, Ning, Wang, Junli, Ma, Kangkang, Liang, Lin, Mi, Lipei, Huang, Wei, Ma, Xiaofeng, Wang, Zeyu, Zheng, Wei, Xu, Linyan, Chen, Jun-Hu, Yu, Zhongbo“…Our single-molecule rescue-rope-strategy will serve as a general tool to investigate telomere dynamics and further develop triplex-based biotechnologies.…”
Publicado 2019
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29406Myceliophthora thermophila Xyr1 is predominantly involved in xylan degradation and xylose catabolismpor dos Santos Gomes, Ana Carolina, Falkoski, Daniel, Battaglia, Evy, Peng, Mao, Nicolau de Almeida, Maira, Coconi Linares, Nancy, Meijnen, Jean-Paul, Visser, Jaap, de Vries, Ronald P.“…By revealing the range of genes controlled by MtXlr1, our results provide the basic knowledge for targeted strain improvement by overproducing or constitutively activating this regulator, to further improve the biotechnological value of M. thermophila.…”
Publicado 2019
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29407por Uhoraningoga, Albert, Kinsella, Gemma K., Frias, Jesus M., Henehan, Gary T., Ryan, Barry J.“…They offer both hydrolysis and synthesis capacity for a wide range of biotechnological processes. However, the availability of native, or the production of recombinant β-glucosidases, is currently a bottleneck in the widespread industrial application of this enzyme. …”
Publicado 2019
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29408por Khan, Aqib Zafar, Bilal, Muhammad, Mehmood, Shahid, Sharma, Ashutosh, Iqbal, Hafiz M. N.“…Owing to the relatively fast growth rate, genetic malleability, and carbon neutral production process, cyanobacteria has been recognized as a specialized microorganism with a significant biotechnological perspective. Metabolically engineering cyanobacterial strains have shown great potential for the photosynthetic production of an array of valuable native or non-native chemicals and metabolites with profound agricultural and pharmaceutical significance using CO(2) as a building block. …”
Publicado 2019
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29409por Roth, Christian, Moroz, Olga V., Turkenburg, Johan P., Blagova, Elena, Waterman, Jitka, Ariza, Antonio, Ming, Li, Tianqi, Sun, Andersen, Carsten, Davies, Gideon J., Wilson, Keith S.“…Amylases are probably the best studied glycoside hydrolases and have a huge biotechnological value for industrial processes on starch. …”
Publicado 2019
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29410por Beleneva, Irina A., Efimova, Kseniya V., Eliseikina, Marina G., Svetashev, Vasilii I., Orlova, Tatiana Yu.“…Such feature of the A. macleodii strain 2328 makes it quite attractive for biotechnological application as an organism concentrating the rare metalloid.…”
Publicado 2019
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29411por Santos, Yossef López de los, Chew-Fajardo, Ying Lian, Brault, Guillaume, Doucet, Nicolas“…Beneficial replacements were observed by screening only 0.308% of the theoretical library size, illustrating how semi-rational approaches with targeted diversity can quickly facilitate the discovery of improved activity variants relevant to a number of biotechnological applications.…”
Publicado 2019
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29412por Bohr, Søren S.-R., Lund, Philip M., Kallenbach, Amalie S., Pinholt, Henrik, Thomsen, Johannes, Iversen, Lars, Svendsen, Allan, Christensen, Sune M., Hatzakis, Nikos S.“…Lipases are interfacially activated enzymes that catalyze the hydrolysis of ester bonds and constitute prime candidates for industrial and biotechnological applications ranging from detergent industry, to chiral organic synthesis. …”
Publicado 2019
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29413“…Combining theoretical models with experimental tests for stability under varying conditions can lead to improved engineering of viral modified genomes, which is a valuable tool for understanding genome evolution as well as for biotechnological applications, such as gene therapy.…”
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29414por Rozova, Olga N., Mustakhimov, Ildar I., But, Sergei Y., Reshetnikov, Aleksandr S., Khmelenina, Valentina N.“…Methanotrophs mitigate the emission of anthropogenic and natural greenhouse gas methane to the environment and are the promising agents for future biotechnologies. Many aspects of CH(4) bioconversion by methanotrophs require further clarification. …”
Publicado 2019
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29415por Otto, Maximilian, Teixeira, Paulo Gonçalves, Vizcaino, Maria Isabel, David, Florian, Siewers, Verena“…Saccharomyces cerevisiae is an established workhorse for the biotechnological production of chemicals. In this study, we constructed and characterised an ABA-producing S. cerevisiae strain using the ABA biosynthetic pathway from Botrytis cinerea. …”
Publicado 2019
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29416por Giraldo, Paula A., Shinozuka, Hiroshi, Spangenberg, German C., Cogan, Noel O.I., Smith, Kevin F.“…Modern agricultural biotechnologies, such as genetic modification, are a possible solution through enabling an increase of production, more efficient use of natural resources, and reduced environmental impacts. …”
Publicado 2019
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29417“…(median: 5.9%; 0.03%–14.3%), a group that has been used for numerous biotechnological applications because of its biodegradative capabilities. …”
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29418por van Erven, Gijs, Wang, Jianli, Sun, Peicheng, de Waard, Pieter, van der Putten, Jacinta, Frissen, Guus E., Gosselink, Richard J. A., Zinovyev, Grigory, Potthast, Antje, van Berkel, Willem J. H., Kabel, Mirjam A.“…[Image: see text] The white-rot fungus Ceriporiopsis subvermispora delignifies plant biomass extensively and selectively and, therefore, has great biotechnological potential. We previously demonstrated that after 7 weeks of fungal growth on wheat straw 70% w/w of lignin was removed and established the underlying degradation mechanisms via selectively extracted diagnostic substructures. …”
Publicado 2019
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29419“…The toxin-antitoxin (TA) systems have been attracting attention due to their role in regulating stress responses in prokaryotes and their biotechnological potential. Much recognition has been given to type II TA system of mesophiles, while thermophiles have received merely limited attention. …”
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29420por Bosseboeuf, Adrien, Baron, Amandine, Duval, Elise, Gautier, Aude, Sourdaine, Pascal, Auvray, Pierrick“…In this context, alternative strategies using biotechnologies, such as marine peptides, have been developed based on their promise of effectivity associated with a low toxicity for healthy cells. …”
Publicado 2019
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