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2861por Houben, Philipp, Hohenberger, Ralph, Yamanaka, Kenya, Büchler, Markus W., Schemmer, Peter“…Based on experimental data, this study was designed to assess both nuclear high mobility group box-1 (HMGB-1) protein and arginine-specific proteolytic activity (ASPA) in the graft effluent. …”
Publicado 2018
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2862“…We describe a 25-year-old man who presented with severe ischemia of the right hand secondary to an idiopathic true radial artery aneurysm at the anatomic snuff box. The patient had embolic occlusions in his hand and fingers that were treated with catheter-directed thrombolysis. …”
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2863“…Accordingly, strategies for arresting oxidative stress-induced chondrocyte dysfunction may lead to new potential therapeutic targets for OA treatment. Forkhead box O (FoxO) transcription factors have recently been shown to play a protective role in chondrocyte dysfunction through the regulation of inflammation, autophagy, aging, and oxidative stress. …”
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2864por Shibata, Tomohiro, Tokunaga, Eriko, Hattori, Satoshi, Watari, Kosuke, Murakami, Yuichi, Yamashita, Nami, Oki, Eiji, Itou, Junji, Toi, Masakazu, Maehara, Yoshihiko, Kuwano, Michihiko, Ono, Mayumi“…The enhanced expression of the Y-box binding protein YBX1 is consistently correlated with poor outcomes or reduced survival of breast cancer patients. …”
Publicado 2018
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2865por Chen, Yanchun, Wang, Qiaozhen, Wang, Qing, Liu, Jinmeng, Jiang, Xin, Zhang, Yawen, Liu, Yongxin, Zhou, Fenghua, Liu, Huancai“…Currently, there is no effective therapeutic regimens available for the treatment of OS. DEAD-box helicase 5 (DDX5) is involved in oncogenic processes. …”
Publicado 2019
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2866por Penrose, Harrison M., Cable, Chloe, Heller, Sandra, Ungerleider, Nathan, Nakhoul, Hani, Baddoo, Melody, Hartono, Alifiani B., Lee, Sean B., Burow, Matthew E., Flemington, Erik F., Crawford, Susan E., Savkovic, Suzana D.“…BACKGROUND & AIMS: Diminished forkhead box O3 (FOXO3) function drives inflammation and cancer growth; however, mechanisms fostering these pathobiologies are unclear. …”
Publicado 2018
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2867por Sachdev, Ruchika, Hondele, Maria, Linsenmeier, Miriam, Vallotton, Pascal, Mugler, Christopher F, Arosio, Paolo, Weis, Karsten“…Previously, we identified the ATPase activity of the DEAD-box protein Dhh1 as a key regulator of PB dynamics and demonstrated that Not1, an activator of the Dhh1 ATPase and member of the CCR4-NOT deadenylase complex inhibits PB assembly in vivo (Mugler et al., 2016). …”
Publicado 2019
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2868por Ma, Hongbing, Zheng, Shuyu, Zhang, Xiaozhi, Gong, Tuotuo, Lv, Xin, Fu, Shenbo, Zhang, Shuqun, Yin, Xiaoran, Hao, Jingcan, Shan, Changyou, Huang, Shan“…Resistance to radiotherapy results in relapse and treatment failure in locally advanced esophageal squamous cell carcinoma (ESCC). High mobility group box 1 (HMGB1) is reported to be associated with the radioresistance in bladder and breast cancer. …”
Publicado 2019
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2869por Zhu, Bin, Li, Nanfang, Zhu, Qing, Wu, Ting, Heizati, Mulalibieke, Wang, Guoliang, Yao, Xiaoguang, Luo, Qin, Liu, Shasha, Liu, Shanshan, Hong, Jing“…High mobility group box 1 (HMGB1) is a kind of proinflammatory mediator that acts as an alarmin when released by dying, injured or activated cells. …”
Publicado 2019
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2870“…Ankyrin-repeat and SOCS-box protein 9 (ASB9) is a member of the large SOCS-box containing proteins family and acts as the specific substrate recognition component of E3 ubiquitin ligases in the process of ubiquitination and proteasomal degradation. …”
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2871por Inkaya, Ahmet Cagkan, Demir, Nazlim Aktug, Kolgelier, Servet, Sumer, Sua, Demir, Lutfi Saltuk, Ural, Onur, Pehlivan, Fatma Seher, Aslan, Mahmure, Arpaci, Abdullah“…BACKGROUND: High-mobility group box 1 (HMGB1), identified as an alarmin molecule, was shown to have a role in virus-triggered liver injury. …”
Publicado 2017
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2872“…In normal tissues, numerous proteins encoded by proto-oncoproteins are degraded by ubiquitylation enzymes, consisting of F-box/WD-40 repeat-containing protein 7 (Fbw7) and other proteins, thus avoiding tumorigenesis and maintaining homeostasis. …”
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2874por Takahashi, Tetsuya, Shishido, Tetsuro, Kinoshita, Daisuke, Watanabe, Ken, Toshima, Taku, Sugai, Takayuki, Narumi, Taro, Otaki, Yoichiro, Tamura, Harutoshi, Nishiyama, Satoshi, Arimoto, Takanori, Takahashi, Hiroki, Miyamoto, Takuya, Watanabe, Tetsu, Woo, Chang-Hoon, Abe, Jun-ichi, Takeishi, Yasuchika, Kubota, Isao, Watanabe, Masafumi“…High-mobility group box 1 (HMGB1) is a deoxyribonucleic acid (DNA)–binding protein associated with DNA repair. …”
Publicado 2019
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2875por Maier, Eva, Attenberger, Felix, Tiwari, Aadhya, Lettau, Konstanze, Rebholz, Simone, Fehrenbacher, Birgit, Schaller, Martin, Gani, Cihan, Toulany, Mahmoud“…KRAS-mutated colorectal cancers (CRCs) are resistant to cetuximab treatment. The multifunctional Y-box binding protein 1 (YB-1) is overexpressed in CRC and is associated with chemoresistance. …”
Publicado 2019
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2876por Lee, Jeong-Jun, Han, Young-Min, Kwon, Tae-Wan, Kim, Dong Hyun, Lee, Han Sol, Jung, Woo Jin, Kim, Jina, Kang, Sujin, Kim, Sang Kyum, Cho, Cheong-Weon, Lee, Keong-Ryoon, Kim, Dae-Duk, Park, Min Chul, Lee, Jae-Young“…The excipient composition of the hydrosol was optimized to maximize the viscosity and drying rate by using Box-Behnken design. The artificial skin deposition of FA-AdP-loaded hydrosol was evaluated using Keshary-Chien diffusion cells equipped with Strat-M membrane (STM). …”
Publicado 2019
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2877“…To forecast the performance of landslides with creep deformation at a regional scale, a black box model based on statistical analysis was proposed and was applied to Yunyang County in the Three Gorges Reservoir area (TGRA), China. …”
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2878“…In addition, ectopic miR-937 expression hindered breast cancer tumor growth in vivo. Forkhead box Q1 (FOXQ1) mRNA was found to be a direct target of miR-937 in breast cancer. …”
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2880“…This study aimed to investigate the association of serum high-mobility group box-1 (HMGB1) and toll-like receptor 4 (TLR4) expressions with the risk of epilepsy as well as their correlations with disease severity and resistance to anti-epilepsy drugs. …”
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