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1041“…INCENP is a scaffolding subunit for the CPC and activates Aurora B via its conserved IN-box domain. We show that overexpression of soluble IN-box in HeLa cells affects endogenous CPC localization and produces a significant increase in multinucleated and micronucleated cells consistent with CPC loss of function. …”
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1042por Daminato, Margherita, Masiero, Simona, Resentini, Francesca, Lovisetto, Alessandro, Casadoro, Giorgio“…BACKGROUND: The identity of flower organs is specified by various MIKC MADS-box transcription factors which act in a combinatorial manner. …”
Publicado 2014
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1043“…Primers corresponding to conserved bacterial repetitive of BOX elements were used to show that BOX-DNA sequences are widely distributed in phosphate solubilizing Pseudomonas strains. …”
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1044por WANG, XIN-JUN, ZHOU, SHAO-LONG, FU, XU-DONG, ZHANG, YAN-YAN, LIANG, BO, SHOU, JI-XIN, WANG, JIAN-YE, MA, JIAN“…The objective of this study was to explore the expression and the clinical and prognostic significance of high-mobility group box-1 (HMGB1) in human gliomas. The expression of HMGB1 in 15 samples of normal brain tissue and 65 samples of different-grade glioma tissue was assayed using immunohistochemistry and western blot analysis. …”
Publicado 2015
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1045por Sun, Shanping, Zhang, Wei, Cui, Zhaoqing, Chen, Qi, Xie, Panpan, Zhou, Changxin, Liu, Baoguo, Peng, Xiangeng, Zhang, Yang“…BACKGROUND: High mobility group box-1 (HMGB1) is a factor regulating malignant tumorigenesis, proliferation, and metastasis, and is associated with poor clinical pathology in various human cancers. …”
Publicado 2015
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1046
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1047por Nowakowska, Sylwia, Wäckerlin, Aneliia, Kawai, Shigeki, Ivas, Toni, Nowakowski, Jan, Fatayer, Shadi, Wäckerlin, Christian, Nijs, Thomas, Meyer, Ernst, Björk, Jonas, Stöhr, Meike, Gade, Lutz H., Jung, Thomas A.“…Here we present an approach to study a condensation process atom-by-atom with the scanning tunnelling microscope, which provides a direct real-space access with atomic precision to the aggregates formed in atomically defined ‘quantum boxes’. Our analysis reveals the subtle interplay of competing directional and nondirectional interactions in the emergence of structure and provides unprecedented input for the structural comparison with quantum mechanical models. …”
Publicado 2015
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1048“…Genes can be divided into TATA-containing genes and TATA-less genes according to the presence of TATA box elements at promoter regions. TATA-containing genes tend to be stress-responsive, whereas many TATA-less genes are known to be related to cell growth or “housekeeping” functions. …”
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1049
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1050
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1051
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1052por Arquint, Christian, Gabryjonczyk, Anna-Maria, Imseng, Stefan, Böhm, Raphael, Sauer, Evelyn, Hiller, Sebastian, Nigg, Erich A, Maier, Timm“…STIL-CC is the first identified interaction partner of Polo-box 3 (PB3) of PLK4 and also uses a secondary interaction site in the PLK4 L1 region. …”
Publicado 2015
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1054por Tosto, Giuseppe, Fu, Hongjun, Vardarajan, Badri N, Lee, Joseph H, Cheng, Rong, Reyes-Dumeyer, Dolly, Lantigua, Rafael, Medrano, Martin, Jimenez-Velazquez, Ivonne Z, Elkind, Mitchell S V, Wright, Clinton B, Sacco, Ralph L, Pericak-Vance, Margaret, Farrer, Lindsay, Rogaeva, Ekaterina, St George-Hyslop, Peter, Reitz, Christiane, Mayeux, Richard“…INTERPRETATION: FBXL7, encodes a subcellular protein involved in phosphorylation-dependent ubiquitination processes and displays proapoptotic activity. F-box proteins also modulate inflammation and innate immunity, which may be important in LOAD pathogenesis. …”
Publicado 2015
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1055“…In a synthesis of the findings, we produced a “black box” model of how knowledge translation was enabled by the activation of nine mechanisms. …”
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1056por Park, Jung-Eun, Kim, Tae-Sung, Meng, Lingjun, Bang, Jeong K., Kim, Bo Y., Lee, Kyung S.“…Consequently, as an alternative approach for developing anti-Plk1 therapeutics, substantial effort is under way to develop inhibitors that target the C-terminal protein–protein interaction domain of Plk1, called the polo-box domain (PBD). In this communication, I will discuss the pros and cons of targeting the PBD in comparison to those of targeting the ATP-binding site within the kinase domain.…”
Publicado 2015
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1057“…Neural networks are often treated as a black box, whose inner workings are concealed from the researcher. …”
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1058por Cutts, Erin E., Inglis, Alison, Stansfeld, Phillip J., Vakonakis, Ioannis, Hatzopoulos, Georgios N.“…G-box fibrils were observed in crystals as well as in solution and are also supported by simulations. …”
Publicado 2015
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1059“…Then, the modified box dimension depending on the weighted factor and the number of copies is deduced. …”
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1060“…Bovine helicases were identified using the helicase domain sequences including 38 DDX (DEAD box) and 16 DHX (DEAH box) members. Signature motifs were used for the validation of these proteins. …”
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