“…Postsurgical corneas were monitored daily with their histological properties examined during a period of 104 days after transplantation. …”
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“…In human corneas ex vivo, F4/80 positive macrophages were observed around the wound site. …”
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“…PURPOSE: To compare the structural integrity and functional status of the donor corneas stored in Cornisol and Optisol-GS. METHODS: Fifteen optical grade corneal donor buttons (6 pairs; 3 individual) obtained from Rotary Aravind International Eye Bank were used for the study. …”
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“…After 2 months, rabbits were sacrificed and corneas removed for histological analysis. RESULTS: Corneas remained clear in all but two animals, and five cases of corneal neovascularization were seen (P = 0.2). …”
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“…A large validation dataset comprising 62 matching samples (31 keratoconus and 31 normal corneas) and 203 unmatching samples (112 keratoconus and 91 normal corneas) was used to evaluate its clinical significance. …”
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“…Cysts exposed to pɛK(+) hydrogels in PYG medium resulted in 75.37% and 87.14% death at 24 hours and 7 days. Ex vivo corneas infected with trophozoites and incubated with pɛK(+) hydrogels showed the absence of A. castellanii in the stroma, with no regrowth from corneas or pɛK(+) hydrogel, compared with infected-only corneas and those incubated in presence of commercial hydrogel CL. …”
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“…Keratitis was induced in the right central corneas of rabbits, whereas the left eyes served as a normal group. …”
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“…Treatment of donor corneas with interleukin-10 (IL-10) and transforming growth factor-β1 (TGFβ1) altered the phenotype and function of tissue-residing APCs. …”
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“…METHODS: A prospective comparative clinical study was conducted between February and September 2011 on 30 eyes divided into four groups, i.e. 20 corneas of 10 patients before LASIK (group A), 20 corneas of the same patients 2 months postoperatively (group B), 10 corneas of five patients before Epi-LASIK (group C), and 10 corneas of the same patients 2 months postoperatively (group D). …”
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“…Group-B: eyes with steeper corneas (20 eyes, 10 patients) with mean keratometric readings ranging from 43.85 to 46.72 D. …”
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“…Pachymetric readings were progressively lower in the bilateral subclinical keratoconus eyes and sensitivity and specificity of the analyzed tomographic and topographic parameters were higher than the fellow eyes group when differentiating subclinical keratoconus from healthy corneas. CONCLUSION: Scheimpflug tomography parameters such as D value, elevation parameters, progression index and several surface indices can effectively differentiate keratoconus from normal corneas in a Caucasian population. …”
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“…However, corneal transplants, including lamellar strategies, have their own set of challenges, such as graft rejection, delayed graft failure, shortage of donor corneas, repeated treatments, and post-surgical complications. …”
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“…The corneas maintained a smooth surface and clear stroma postoperatively after 7 months of implantation of collagen–HPMC membranes into the corneas of rabbits. …”
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“…We also examined the effect of CCL2 on the injury response in Mmp12(−/−) and WT corneas. We found that macrophage infiltration and neovascularization following CCL2 blockade was significantly reduced in Mmp12(−/−) corneas as compared with WT corneas. …”
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“…Ex vivo, HSV-1 infection rates of meganuclease-treated human corneas were drastically reduced. Furthermore, genetically engineered corneas transplanted in vivo into rabbit eyes protected against HSV-1 infection. …”
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“…PURPOSE: To examine the efficacy of a novel method of decellularizing porcine corneal stroma using N(2) gas from liquid N(2) and the feasibility of using decellularized porcine corneal stroma in a corneal transplantation model in rabbits. METHODS: Porcine corneas were placed in a tube, and N(2) gas from liquid N(2) was poured into the tube to freeze the corneas and make the inside of the tube hypoxic. …”
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“…There is a critical shortage of organs, cells, and corneas from deceased human donors worldwide. There are also shortages of human blood for transfusion. …”
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“…The tomography and biomechanical parameters of the keratoconic corneas were significantly different from those of the normal corneas except for the anterior chamber angle, first applanation length, the highest concavity time, and peak distance. …”
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“…Laser soldering was then performed on penetrating incisions made in the corneas of live healthy piglets, of weight [Formula: see text]. …”
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“…CONCLUSION: Judicious use of steroids in the initial postoperative period is recommended so as to prevent any form of microbial keratitis. Very steep corneas and too thin corneas should be looked with high index of suspicion in view of chances of developing sterile infiltrates.…”
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