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  1. 1981
    “…We identified the 1b region as a critical disease-relevant regulatory element and provide evidence that non-canonical and seemingly redundant promoters can have essential function.…”
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    Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice
  2. 1982
    “…Here, we determined the involvement of the kinase Gsk3β and the small GTPase Rac1 in non-canonical Wnt signaling and its regulation of the planar cell polarity (PCP) pathway in the cochlea. …”
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    Non-Canonical Wnt Signaling Regulates Cochlear Outgrowth and Planar Cell Polarity via Gsk3β Inhibition
  3. 1983
    “…Canonical correlation analysis (CCA), a multivariate approach to identifying correlations between two sets of variables, is becoming increasingly popular in neuroimaging studies on brain‐behavior relationships. …”
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    Stability test of canonical correlation analysis for studying brain‐behavior relationships: The effects of subject‐to‐variable ratios and correlation strengths
  4. 1984
    “…We found a dominance for NF-κB signaling upon CD40 stimulation, which results in activation of both the canonical and non-canonical NF-κB signaling pathways. …”
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    Regulation of Bcl-XL by non-canonical NF-κB in the context of CD40-induced drug resistance in CLL
  5. 1985
    “…Here, we present data on characterisation of the linker of Plasmodium falciparum Hsp110 (PfHsp70-z) relative to the linker of canonical Hsp70s in support of a co-published article [1]. …”
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    Supporting data on characterisation of linker switch mutants of Plasmodium falciparum heat shock protein 110 and canonical Hsp70
  6. 1986
    “…Here, we show that Rela (encoding a canonical NF-κB subunit) ablation in K14(+) corneal epithelial stem cells not only disrupts corneal regeneration but also results in age-dependent epithelial deterioration, which triggers aberrant wound-healing processes including stromal remodeling, neovascularization, epithelial metaplasia, and plaque formation at the central cornea. …”
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    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid
  7. 1987
    “…Using recent structures of KCNQ1 and KCNE beta subunits in different states, we present a mechanism by which KCNE1 rotates the VSD relative to the PD and affects the VSD–PD coupling of KCNQ1 channels in a non-canonical way, forcing KCNQ1/KCNE1 channels to open in the fully-activated VSD state. …”
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    A general mechanism of KCNE1 modulation of KCNQ1 channels involving non-canonical VSD-PD coupling
  8. 1988
    “…Yet, some MLL-rearranged leukemias are inexplicably susceptible to low-dose pinometostat, far below concentrations that downregulate this canonical proliferation pathway. In this context, we define alternative proliferation pathways that more directly derive from H3K79me2 loss. …”
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    Non-canonical H3K79me2-dependent pathways promote the survival of MLL-rearranged leukemia
  9. 1989
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    X-linked serotonin 2C receptor is associated with a non-canonical pathway for sudden unexpected death in epilepsy
  10. 1990
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    Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons
  11. 1991
    por Han, Qi, He, Xiaoyun, Di, Ran, Chu, Mingxing
    Publicado 2021
    “…This study was conducted to analyze the expression patterns of six canonical clock genes (Clock, BMAL1, Per1, Per2, Cry1, and Cry2) in the follicle phase and luteal phase of STH sheep. …”
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    Comparison of expression patterns of six canonical clock genes of follicular phase and luteal phase in Small-tailed Han sheep
  12. 1992
    “…The non-canonical inflammasome pathway involves caspase-11. …”
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    Differential involvement of the canonical and noncanonical inflammasomes in the immune response against infection by the periodontal bacteria Porphyromonas gingivalis and Fusobacterium nucleatum
  13. 1993
    “…[Image: see text] Non-canonical protonation at cytosine (C) in DNA is related to a formation of second order DNA structures such as i-motif, which has a role in gene regulation. …”
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    Changes of C≡C Triple Bond Vibration that Disclosed Non-Canonical Cytosine Protonation in i-Motif-Forming Oligodeoxynucleotides
  14. 1994
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    Author Correction: Genomic analysis finds no evidence of canonical eukaryotic DNA processing complexes in a free-living protist
  15. 1995
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    Thyroid Hormone Nuclear Receptor TRα1 and Canonical WNT Pathway Cross-Regulation in Normal Intestine and Cancer
  16. 1996
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    Canonical WNT signaling-dependent gating of MYC requires a noncanonical CTCF function at a distal binding site
  17. 1997
    “…Overall, Compound 4e is able to overcome the catabolic effect of dexamethasone on bone by targeting the canonical WNT/β-catenin signaling as evidenced by both in vitro and in vivo studies.…”
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    Benzofuran pyran hybrid prevents glucocorticoid induced osteoporosis in mice via modulation of canonical Wnt/β-catenin signaling
  18. 1998
    por Le Dréau, Gwenvael
    Publicado 2022
    “…In this mini-review, I summarize accumulating evidence demonstrating how the canonical BMP activity promotes the amplification and/or maintenance of neural stem cells at different times and in diverse regions of the vertebrate CNS, and highlight findings suggesting that this function is evolutionarily conserved.…”
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    BuMPing Into Neurogenesis: How the Canonical BMP Pathway Regulates Neural Stem Cell Divisions Throughout Space and Time
  19. 1999
    “…In murine corneal wound healing models, the canonical Wnt signaling was activated in nondiabetic corneas and suppressed in diabetic corneas, correlating with delayed wound healing. …”
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    Pathogenic Role of Diabetes-Induced Overexpression of Kallistatin in Corneal Wound Healing Deficiency Through Inhibition of Canonical Wnt Signaling
  20. 2000
    “…Of note, despite the blockage of “canonical” miRNA biogenesis, miR-155 remains upregulated in FLT3-ITD+ AML blasts, suggesting activation of alternative mechanisms of miRNA biogenesis that circumvent the XPO5/RAN-GTP blockage. …”
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    Cytoplasmic DROSHA and Non-canonical Mechanisms of MiR-155 Biogenesis in FLT3-ITD Acute Myeloid Leukemia
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