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  1. 2001
    “…Meanwhile, as one of the major oncogenic pathways, its upregulation has been observed in many cancer types. Compared with canonical NF-κB signaling, its non-canonical branch was much less studied in cancerous context. …”
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    Non-Canonical NF-κB Signaling Stratifies LGG into Subtypes with Distinct Molecular and Cellular Characteristic and Survival Expectancy
  2. 2002
    “…RNA‐seq analysis and coimmunoprecipitation assays indicate that HTR1A interacts with TRIM21 and PSMD7 to inhibit the degradation of TβRII through the ubiquitin‐proteasome pathway, thereby inhibiting the transforming growth factor‐β (TGF‐β) canonical and noncanonical pathway. In addition, HTR1A is an independent predictive factor for breast cancer patients. …”
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    HTR1A Inhibits the Progression of Triple‐Negative Breast Cancer via TGF‐β Canonical and Noncanonical Pathways
  3. 2003
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    Disentangling structural and functional responses of native versus alien communities by canonical ordination analyses and variation partitioning with multiple matrices
  4. 2004
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    Delta-like canonical Notch ligand 1 is predictive for sepsis and acute kidney injury in surgical intensive care patients
  5. 2005
    “…CONCLUSIONS: Early activation of the canonical NLRP3 inflammasome induced pyroptosis in ventral horn neurons, which may participate in motor neuron degeneration and initiate neuroinflammatory processes during ALS progression. …”
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    Spatiotemporal evolution of pyroptosis and canonical inflammasome pathway in hSOD1(G93A) ALS mouse model
  6. 2006
    “…Here, we report that AR-V7 has unique biological features that functionally differentiate it from canonical AR-fl or from the second most prevalent variant, AR-v567. …”
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    AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer
  7. 2007
    “…We investigated the influence of IRAK1 overexpression on the canonical NF-κB signaling as a possible cause for excessive inflammation in these patients. …”
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    IRAK1 Duplication in MECP2 Duplication Syndrome Does Not Increase Canonical NF-κB–Induced Inflammation
  8. 2008
    “…To address this issue, a multi-user sEMG framework is proposed, using discriminative canonical correlation analysis and adaptive dimensionality reduction (ADR). …”
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    Multi-user motion recognition using sEMG via discriminative canonical correlation analysis and adaptive dimensionality reduction
  9. 2009
    “…Here, we report that activated STING could be transferred between cells to promote antitumor immunity, a process triggered by RAB22A-mediated non-canonical autophagy. Mechanistically, RAB22A engages PI4K2A to generate PI4P that recruits the Atg12–Atg5–Atg16L1 complex, inducing the formation of ER-derived RAB22A-mediated non-canonical autophagosome, in which STING activated by agonists or chemoradiotherapy is packaged. …”
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    Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity
  10. 2010
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    Canonical and uncanonical pathogenic germline variants in colorectal cancer patients by next-generation sequencing in a European referral center
  11. 2011
    por Cho, Hui-Jin, Kim, Eojin, Yi, Young-Su
    Publicado 2023
    “…This study explored the anti-inflammatory activity of the KRG saponin fraction (KRGSF) in caspase-11 non-canonical inflammasome-activated macrophages. KRGSF inhibited pyroptosis, pro-inflammatory cytokine secretion, and inflammatory mediator production in caspase-11 non-canonical inflammasome-activated J774A.1 cells. …”
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    Korean Red Ginseng Saponins Play an Anti-Inflammatory Role by Targeting Caspase-11 Non-Canonical Inflammasome in Macrophages
  12. 2012
    “…The discovery of non‐canonical protein sequences questions existing gene models and pinpoints new protein targets for research in GBM.…”
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    Glioblastoma stem cells express non‐canonical proteins and exclusive mesenchymal‐like or non‐mesenchymal‐like protein signatures
  13. 2013
    “…BACKGROUND: Canonical Wnt signaling is involved in a variety of biological processes including stem cell renewal and differentiation, embryonic development, and tissue regeneration. …”
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    Canonical Wnt signaling activation by chimeric antigen receptors for efficient cardiac differentiation from mouse embryonic stem cells
  14. 2014
    “…To circumvent this problem, we have implemented patch-clamp fluorometry in combination with the incorporation of the fluorescent non-canonical amino acid Anap to monitor channel opening and movement of the S4 segment. …”
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    Activation-pathway transitions in human voltage-gated proton channels revealed by a non-canonical fluorescent amino acid
  15. 2015
    Publicado 1997
    “…Area de Protección de Flora y Fauna Cañón de Santa Elena (México).…”
    Libro
    Programa de manejo del Area de Protección de Flora y Fauna Cañón de Santa Elena, México.
  16. 2016
    “…(Met1702*)), and a non‐canonical splice site variant of unclear significance (c.886‐5T>A; p.?). …”
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    Characterization of a novel non‐canonical splice site variant (c.886‐5T>A) in NBAS and description of the associated phenotype
  17. 2017
    “…Notably, DPP4 activates this pathway in an enzymatic activity-independent manner, suggesting the non-canonical role of DPP4 in the pathogenesis of mitochondria calcium overload and cognitive impairment in diabetes. …”
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    Non-canonical function of DPP4 promotes cognitive impairment through ERp29-associated mitochondrial calcium overload in diabetes
  18. 2018
    “…Here we incorporated the non‐canonical amino acid p‐cyanophenylalanine (CNF) by genetic code expansion technology at 45 positions of the bacterial transcription factor EL222. …”
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    Genetically encoded non‐canonical amino acids reveal asynchronous dark reversion of chromophore, backbone, and side‐chains in EL222
  19. 2019
    “…Our work provides evidence that orthogonal gene engineering of T cells to secrete an interleukin (IL)-2 variant binding the IL-2Rβγ receptor and the alarmin IL-33 reprogrammed adoptively transferred T cells to acquire a novel, synthetic effector state, which deviated from canonical exhaustion and displayed superior effector functions. …”
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    Orthogonal cytokine engineering enables novel synthetic effector states escaping canonical exhaustion in tumor-rejecting CD8(+) T cells
  20. 2020
    “…Polycomb repressive complex 2 (PRC2) mediates H3K27me3 deposition, which is thought to recruit canonical PRC1 (cPRC1) via chromodomain-containing CBX proteins to promote stable repression of developmental genes. …”
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    PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1
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