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  1. 20361
    “…In this study, we first employed a bioinformatic approach to elucidate the potential regulatory breadth of OxyR by scanning the entire P. aeruginosa PAO1 genome for canonical OxyR promoter recognition sequences (ATAG-N(7)-CTAT-N(7)-ATAG-N(7)-CTAT). …”
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    The OxyR-regulated phnW gene encoding 2-aminoethylphosphonate:pyruvate aminotransferase helps protect Pseudomonas aeruginosa from tert-butyl hydroperoxide
  2. 20362
    “…These OSTs have different peptide acceptor and lipid-linked oligosaccharide donor specificities, and trypanosomes do not follow many of the canonical rules developed for other eukaryotic N-glycosylation pathways, raising questions as to the basic architecture and detailed function of trypanosome OSTs. …”
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    Single-subunit oligosaccharyltransferases of Trypanosoma brucei display different and predictable peptide acceptor specificities
  3. 20363
    “…These data indicate that burn injury affects the β-AR signaling pathway in the RV independently of the LV. Additionally, non-canonical β-AR signaling may be activated in the RV as cAMP production and PKA activity were unchanged despite changes in β(1)-AR protein expression.…”
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    Biventricular differences in β-adrenergic receptor signaling following burn injury
  4. 20364
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    RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer
  5. 20365
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    Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1
  6. 20366
    “…High-dose radiotherapy effects are regulated by acute tumour endothelial cell death followed by rapid tumour cell death instead of canonical DNA break damage. Pre-treatment with ultrasound-stimulated microbubbles (USMB) has enabled higher-dose radiation effects with conventional radiation doses. …”
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    Tumour Vascular Shutdown and Cell Death Following Ultrasound-Microbubble Enhanced Radiation Therapy
  7. 20367
    “…Ingenuity Pathway Analysis identified several immune-related pathways as key Canonical Pathways that were differentially regulated, specifically human leukocyte antigen expression and immunoglobulin production genes were upregulated. …”
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    Modulation of Immunological Pathways in Autistic and Neurotypical Lymphoblastoid Cell Lines by the Enteric Microbiome Metabolite Propionic Acid
  8. 20368
    “…Both TgElp3 and TgRlmN contain the canonical rSAM amino acid sequence motif (CxxxCxxC) necessary to form the 4Fe-4S cluster required for tRNA modifications. …”
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    Elp3 and RlmN: A tale of two mitochondrial tail-anchored radical SAM enzymes in Toxoplasma gondii
  9. 20369
    por Wei, Ou, Guo, Zonghao, Niu, Yun, Liao, Wenyuan
    Publicado 2017
    “…It enables a natural depiction of the dynamics of gene regulatory networks, and provides a canonical form to formulate optimal control problems using temporal properties that can be automated solved by leveraging the analysis power of underlying model checking engines. …”
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    Model checking optimal finite-horizon control for probabilistic gene regulatory networks
  10. 20370
    “…Specifically, we used canonical correlation analysis to see if there were any mixtures of prior expectations that could predict between-subject differences in performance; thereby establishing a quantitative link between different behavioural phenotypes and Bayesian belief updating. …”
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    Human visual exploration reduces uncertainty about the sensed world
  11. 20371
    por Baikerikar, Shruti
    Publicado 2017
    “…[Image: see text] Abbreviations Used: EBOV: Ebola virus, GP: Glycoprotein, NP: Nucleoprotein, NPT: Isothermal-isobaric Ensemble, amount of substance (N), pressure (P) and temperature (T) conserved, NVE: Canonical ensemble, amount of substance (N), volume (V) and temperature (T) conserved, VP: Viral protein.…”
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    Curcumin and Natural Derivatives Inhibit Ebola Viral Proteins: An In silico Approach
  12. 20372
    “…Results: Analysis of the mitoribosome residency on transcripts under control conditions reveals that although mitochondria employ only 22 mt-tRNAs for protein synthesis, the use of non-canonical wobble base pairs at codon position 3 does not cause any measurable difference in mitoribosome occupancy irrespective of the codon. …”
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    Using mitoribosomal profiling to investigate human mitochondrial translation
  13. 20373
    “…Homology modeling of PtXyl43 suggested that PtXyl43 had a canonical GH43 family β-xylosidase structure containing five blades. …”
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    Conformational determinants necessary for secretion of Paecilomyces thermophila β-1,4-xylosidase that lacks a signal peptide
  14. 20374
    “…Here, we dissected the specific contribution of C5a receptor 1 (C5aR1), the canonical receptor for C5a, using a mouse model of meningococcal sepsis. …”
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    Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment
  15. 20375
    “…DNA polymerase IV (pol IV) is one of three specialised DNA polymerases called into action during the SOS response to help cells tolerate certain types of DNA damage. The canonical view in the field is that pol IV primarily acts at replisomes that have stalled on the damaged DNA template. …”
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    DNA polymerase IV primarily operates outside of DNA replication forks in Escherichia coli
  16. 20376
    por Kriz, Vitezslav, Korinek, Vladimir
    Publicado 2018
    “…By upregulating Wnt pathway agonists, the alternative Wnt signalling can inhibit the canonical Wnt pathway activity.…”
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    Wnt, RSPO and Hippo Signalling in the Intestine and Intestinal Stem Cells
  17. 20377
    “…Although cell-cycle arrest, senescence and apoptosis remain as major canonical activities of p53 in tumor suppression, the emerging role of p53 in metabolism has been a topic of great interest. …”
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    Inhibition of Mdmx (Mdm4) in vivo induces anti-obesity effects
  18. 20378
    “…Mapping of the changes responsible for splicing perturbations in Group 2 viruses revealed the presence of several RNA sequences that apparently suppressed the use of cryptic or canonical splice sites. Some sequences that affected splicing were diffusely distributed, while others could be mapped to discrete elements, proximal or distal to the affected splice site(s). …”
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    Global synonymous mutagenesis identifies cis-acting RNA elements that regulate HIV-1 splicing and replication
  19. 20379
    “…IL-8 suppression is not mediated by TSST-1 binding to its canonical receptor major histocompatibility complex class II (MHC-II), supporting current evidence for a nonhematopoietic interacting site on SAgs. …”
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    The Superantigen Toxic Shock Syndrome Toxin 1 Alters Human Aortic Endothelial Cell Function
  20. 20380
    “…These kinases occupy positions at the top and bottom level, respectively, in the canonical threetier MAPK-signaling cascade: MAP3K, MAP2K, MAPK. …”
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    Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination
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