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  1. 20401
    “…We found that injected OPF/GO hydrogels can provide mechanical support and electric connection between healthy myocardium and the cardiomyocytes in the scar via activating the canonical Wnt signal pathway, thus upregulating the generation of Cx43 and gap junction associated proteins. …”
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    Injectable OPF/graphene oxide hydrogels provide mechanical support and enhance cell electrical signaling after implantation into myocardial infarct
  2. 20402
    “…HopQ1 shows homology to Nucleoside Hydrolases (NHs), but it contains a modified calcium binding motif not found in the canonical enzymes. CLuster ANalysis of Sequences (CLANS) revealed that HopQ1 and alike proteins make a distinct group of putative NHs located distantly from the classical enzymes. …”
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    An Engineered Distant Homolog of Pseudomonas syringae TTSS Effector From Physcomitrella patens Can Act as a Bacterial Virulence Factor
  3. 20403
    “…Mitochondrial Dysfunction and oxidative phosphorylation, and energy production and nucleic acid metabolism were, respectively, the canonical pathway and the molecular function mainly affected. …”
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    Proteomics Analysis to Assess the Role of Mitochondria in BRCA1-Mediated Breast Tumorigenesis
  4. 20404
    por Ishihara, Keiko
    Publicado 2018
    “…By studying Kir2.1, the canonical member of the sKir channel family, we first show that the outward currents of Kir2.1 are observed under the external K(+)-free condition when its inward rectification is reduced and that the complete inhibition of the currents at 0 [K(+)](out) results solely from pore blockade caused by the polyamines. …”
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    External K(+) dependence of strong inward rectifier K(+) channel conductance is caused not by K(+) but by competitive pore blockade by external Na(+)
  5. 20405
    “…Our findings demonstrated that SR enhanced bone formation and inhibited bone resorption in a wear particle-mediated osteolysis model in wild-type mice, and this effect relied mainly on the down-regulation of sclerostin levels to ameliorate the inhibition of the canonical Wnt pathway.…”
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    Strontium ranelate inhibits wear particle-induced aseptic loosening in mice
  6. 20406
    “…We advocate a systems protobiology view, whereby the first replicators were assemblies of spontaneously accreting, heterogeneous and mostly non-canonical amphiphiles. This view is substantiated by rigorous chemical kinetics simulations of the graded autocatalysis replication domain (GARD) model, based on the notion that the replication or reproduction of compositional information predated that of sequence information. …”
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    Systems protobiology: origin of life in lipid catalytic networks
  7. 20407
    “…Overall, the results of this study show that structural modifications of natural compounds can be an interesting strategy for developing antitumor drugs, with distinct mechanisms of actions, which could possibly be used against triple negative breast cancer cells that are resistant to canonical apoptosis-inducing drugs.…”
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    Autophagy-dependent apoptosis is triggered by a semi-synthetic [6]-gingerol analogue in triple negative breast cancer cells
  8. 20408
    “…Multiple genes were altered in High-Active mice in a manner predicted to downregulate the canonical Wnt pathway. A smaller and different set of genes including glyoxalase (Glo1) were differentially regulated in High-Active as compared to Control in response to amphetamine. …”
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    Striatal transcriptome of a mouse model of ADHD reveals a pattern of synaptic remodeling
  9. 20409
    “…The near-identical loci on CHRV and CHRXVI strongly resembled canonical S. cerevisiae MAL loci, while those on CHRII and CHRXIII showed different structures suggestive of gene loss. …”
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    Structural, Physiological and Regulatory Analysis of Maltose Transporter Genes in Saccharomyces eubayanus CBS 12357(T)
  10. 20410
    “…Postnatal liver development is characterized by hepatocyte growth, proliferation, and functional maturation. Notably, canonical Wnt signaling in hepatocytes has been identified as an important regulator of final adult liver size and metabolic liver zonation. …”
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    Angiocrine Wnt signaling controls liver growth and metabolic maturation in mice
  11. 20411
    por Tian, Jinbin, Zhu, Michael X.
    Publicado 2018
    “…The sEPSC is mediated by transient receptor potential canonical 3 (TRPC3) channels. Often co-localized with mGluR1 in Purkinje neuron dendrites are type B γ-aminobutyric acid receptors (GABA(B)Rs) that respond to inhibitory synaptic inputs from interneurons located in the molecular layer of cerebellar cortex. …”
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    GABA(B) Receptors Augment TRPC3-Mediated Slow Excitatory Postsynaptic Current to Regulate Cerebellar Purkinje Neuron Response to Type-1 Metabotropic Glutamate Receptor Activation
  12. 20412
    “…A 1.5-Å structure of the MLK3 SH3 domain bound to a canonical proline-rich peptide from hepatitis C virus nonstructural 5A (NS5A) protein revealed that it and MIP bind the SH3 domain at two distinct sites, but biophysical analyses suggested that the two peptides compete with each other for SH3 binding. …”
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    Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3
  13. 20413
    “…METHODS: Two machine learning approaches (Scaled Subprofile Model (SSM) and NPAIRS with Canonical Variates Analysis) were performed on FDG-PET scans from 17 healthy controls (HC) and 23 PD patients. …”
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    FDG PET Parkinson’s disease-related pattern as a biomarker for clinical trials in early stage disease
  14. 20414
    “…This set of NRF2 “cancer target genes” includes canonical redox-related NRF2 targets, as well as target genes that have not been previously linked to NRF2 activation. …”
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    A distinct class of antioxidant response elements is consistently activated in tumors with NRF2 mutations
  15. 20415
    “…The floristic and structural distance matrices were correlated with the Mantel test. Canonical correspondence analysis (CCA) related floristic composition to environmental variables sourced from WorldClim, the Atlas of Living Australia and TERN’s Soil and Landscape Grid. …”
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    Floristic and structural assessment of Australian rangeland vegetation with standardized plot-based surveys
  16. 20416
    “…Fisher α diversity indices, Ternary diagrams, Canonical Correspondence Analysis, regression tree analysis and FORAM-Index (FI; a single metric index for evaluating water quality associated with reef development) implied a combined impact from ENSO and upwelling from Equatorial Undercurrent (EUC) waters to primarily impact foraminiferal abundances and drive assemblage patterns throughout the archipelago. …”
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    Effect of seawater temperature, pH, and nutrients on the distribution and character of low abundance shallow water benthic foraminifera in the Galápagos
  17. 20417
    “…To explore the biological significance of Piwil4 in breast cancer growth, we knocked down Piwil4 with multiple siRNAs and observed the suppressed expression of some canonical targets of ER. The knockdown of Piwil4 expression also decreased the migration and invasion capabilities of MCF-7 cells. …”
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    The role of 17β-estradiol-induced upregulation of Piwi-like 4 in modulating gene expression and motility in breast cancer cells
  18. 20418
    “…The ancestral winter VRN-A1 allele in ‘Triple Dirk C’ has one SNP in the RIP3 region (1_SNP) relative to the canonical RIP3 sequence, whereas the derived ‘Jagger’ allele has three SNPs (3_SNPs). …”
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    Single nucleotide polymorphisms in a regulatory site of VRN-A1 first intron are associated with differences in vernalization requirement in winter wheat
  19. 20419
    “…Initially, using single-cell RT-PCR, we determined that mouse POMC(eGFP) neurons express Slc17a6 (Vglut2) and Slc18a2 (Vmat2), but not Slc31a1 (Vgat) mRNA, suggesting glutamate and non-canonical GABA release. Quantitative (q)RT-PCR of POMC(eGFP) cells revealed that Vglut2 and Vmat2 expression was significantly increased in E2- versus oil-treated, ovariectomized (OVX) female mice. …”
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    Estradiol Drives the Anorexigenic Activity of Proopiomelanocortin Neurons in Female Mice
  20. 20420
    “…Notably, CIMS contains a canonical ϕWϕP sequence (APIWRP, amino acids 1832–1837) and directly interacts with CSL-BTD in a mode similar to other BTD-binding corepressors. …”
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    OPTHiS Identifies the Molecular Basis of the Direct Interaction between CSL and SMRT Corepressor
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