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  1. 20481
    “…Remarkably, both apparently replaced a canonical plastid inverted repeat with large directly repeated sequences. …”
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    Mycoheterotrophic Epirixanthes (Polygalaceae) has a typical angiosperm mitogenome but unorthodox plastid genomes
  2. 20482
    por Arkin, Adam P, Cottingham, Robert W, Henry, Christopher S, Harris, Nomi L, Stevens, Rick L, Maslov, Sergei, Dehal, Paramvir, Ware, Doreen, Perez, Fernando, Canon, Shane, Sneddon, Michael W, Henderson, Matthew L, Riehl, William J, Murphy-Olson, Dan, Chan, Stephen Y, Kamimura, Roy T, Kumari, Sunita, Drake, Meghan M, Brettin, Thomas S, Glass, Elizabeth M, Chivian, Dylan, Gunter, Dan, Weston, David J, Allen, Benjamin H, Baumohl, Jason, Best, Aaron A, Bowen, Ben, Brenner, Steven E, Bun, Christopher C, Chandonia, John-Marc, Chia, Jer-Ming, Colasanti, Ric, Conrad, Neal, Davis, James J, Davison, Brian H, DeJongh, Matthew, Devoid, Scott, Dietrich, Emily, Dubchak, Inna, Edirisinghe, Janaka N, Fang, Gang, Faria, José P, Frybarger, Paul M, Gerlach, Wolfgang, Gerstein, Mark, Greiner, Annette, Gurtowski, James, Haun, Holly L, He, Fei, Jain, Rashmi, Joachimiak, Marcin P, Keegan, Kevin P, Kondo, Shinnosuke, Kumar, Vivek, Land, Miriam L, Meyer, Folker, Mills, Marissa, Novichkov, Pavel S, Oh, Taeyun, Olsen, Gary J, Olson, Robert, Parrello, Bruce, Pasternak, Shiran, Pearson, Erik, Poon, Sarah S, Price, Gavin A, Ramakrishnan, Srividya, Ranjan, Priya, Ronald, Pamela C, Schatz, Michael C, Seaver, Samuel M D, Shukla, Maulik, Sutormin, Roman A, Syed, Mustafa H, Thomason, James, Tintle, Nathan L, Wang, Daifeng, Xia, Fangfang, Yoo, Hyunseung, Yoo, Shinjae, Yu, Dantong
    Publicado 2018
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    KBase: The United States Department of Energy Systems Biology Knowledgebase
  3. 20483
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    Guía de práctica clínica del síndrome del intestino irritable con estreñimiento y estreñimiento funcional en adultos: tratamiento. (Parte 2 de 2)()
  4. 20484
    “…These results suggest that canonical neuronal–microglial communication through CD200–CD200R1 interaction is not compromised, and CD200 up-regulation in R6/1 brain parenchyma could represent a neurotrophic signal to sustain or extend neuronal function in the latest stages of HD as pro-survival mechanism.…”
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    CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease
  5. 20485
    “…Bacteriophytochrome proteins (BphPs) are molecular light switches that enable organisms to adapt to changing light conditions through the control of gene expression. Canonical type 1 BphPs have histidine kinase output domains, but type 3 RpBphP1, in the bacterium Rhodopseudomonas palustris (Rps. palustris), has a C terminal PAS9 domain and a two‐helix output sensor (HOS) domain. …”
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    Light‐induced complex formation of bacteriophytochrome RpBphP1 and gene repressor RpPpsR2 probed by SAXS
  6. 20486
    “…We propose a mechanistic model explaining how ERAP1-mediated trimming of MHC I–bound peptides in cells can generate peptides of canonical as well as noncanonical lengths that still serve as stable MHC I ligands. …”
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    ERAP1 enzyme-mediated trimming and structural analyses of MHC I–bound precursor peptides yield novel insights into antigen processing and presentation
  7. 20487
    “…The most heavily weighted variants in the model were within poly(ADP-ribose) polymerase 1 (PARP1) and excision repair cross complementation group 5 (ERCC5), both of which are involved in a canonical aging pathway, DNA damage repair. Conclusion: Overall, this study implemented a framework to apply machine learning to identify sequencing variants associated with complex phenotypes such as aging. …”
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    Exonic Variants in Aging-Related Genes Are Predictive of Phenotypic Aging Status
  8. 20488
    “…Transcription factor binding site analysis revealed that the PDSS2 promoter contains binding sites for canonical transcription factors such as Sp1 and GATA-1. …”
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    Sp1 Mediates the Constitutive Expression and Repression of the PDSS2 Gene in Lung Cancer Cells
  9. 20489
    “…Dysfunctions in transient receptor potential canonical (TRPC) channels are involved in many types of cardiovascular diseases. …”
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    Effect of SKF-96365 on cardiomyocyte hypertrophy induced by angiotensin II
  10. 20490
    “…METHODS: We performed exome sequencing and gene‐based variant association analysis on 31 deeply phenotyped individuals with the canonical 3Mb 22q11.2 deletion to identify what genes outside the 22q11.2 locus may be modifying the immune dysregulated phenotype. …”
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    Candidate modifier genes for immune function in 22q11.2 deletion syndrome
  11. 20491
    “…Here, we announce Detecting Relative Outlier Impacts from Molecular Dynamic Simulation (DROIDS) 3.0, a method and software package for comparative protein dynamics that includes maxDemon 1.0, a multimethod machine learning application that trains on large ensemble comparisons of concerted protein motions in opposing functional states generated by DROIDS and deploys learned classifications of these states onto newly generated MD simulations. Local canonical correlations in learning patterns generated from independent, yet identically prepared, MD validation runs are used to identify regions of functionally conserved protein dynamics. …”
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    DROIDS 3.0—Detecting Genetic and Drug Class Variant Impact on Conserved Protein Binding Dynamics
  12. 20492
    “…WLMs also reported more willingness to ignore food cravings (4.4 vs. 3.5; [Formula: see text]  = 0.16) and had greater habit strength for healthy eating (5.3 vs. 3.2;  [Formula: see text]  = 0.21). Standard canonical coefficients indicated that dietary (0.52), self‐monitoring (0.40), and psychological (0.14) strategies as well as habit strength for healthy eating (0.15) contributed independently and most (49.5% of variance) to discriminating groups. …”
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    Behavioral and Psychological Strategies of Long‐Term Weight Loss Maintainers in a Widely Available Weight Management Program
  13. 20493
    por Zhou, Juan, Jin, Zhehui, Luo, Kai H.
    Publicado 2019
    “…On the other hand, the microscopic mechanism of enhanced shale gas recovery with CO(2) injection and the influence of the subsurface water confined in the shale nanopores remain ambiguous. Here, we use grand canonical Monte Carlo (GCMC) simulations to investigate the effect of moisture on the shale gas recovery and CO(2) sequestration by calculating the adsorption of CH(4) and CO(2) in dry and moist kerogen slit pores. …”
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    Effects of Moisture Contents on Shale Gas Recovery and CO(2) Sequestration
  14. 20494
    “…RESULTS: Hepatocytes expressed multiple isoforms of PGC-1α, including PGC-1α4, which microarray analysis showed had common and isoform-specific functions linked to metabolism and inflammation compared with canonical PGC-1α1. Whereas PGC-1α1 primarily impacted gene programs of nutrient metabolism and mitochondrial biology, TNFα signaling showed several pathways related to innate immunity and cell death downstream of PGC-1α4. …”
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    PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
  15. 20495
    “…Treatment of C3H10T1/2 cells with DMITro + cyclopamine or DMITro + CUR61414 for 96h did not modulate adipocyte differentiation; cyclopamine and CUR61414 did not reverse the inhibitory effects of 25-HC, suggesting that the canonical hedgehog signalling may not play a role in the anti-adipogenic effects of 25-HC in C3H10T1/2 cells. …”
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    25-Hydroxycholesterol Inhibits Adipogenic Differentiation of C3H10T1/2 Pluripotent Stromal Cells
  16. 20496
    “…We demonstrate the efficacy of our assay by determining the specific activity of purified cow FASN and show that in addition to the canonical NEFA 16:0 this enzyme also produces NEFA 12:0, 14:0, 18:0, and 20:0. …”
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    A Simple and Direct Assay for Monitoring Fatty Acid Synthase Activity and Product-Specificity by High-Resolution Mass Spectrometry
  17. 20497
    “…Recently, several studies reported the interaction between these non-canonical peptides and DNA targets. Among the most important DNA targets are the DNA secondary structures known as G-quadruplexes (G4s) which play relevant roles in many biological processes and disease-related mechanisms. …”
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    Evaluation of an Analogue of the Marine ε-PLL Peptide as a Ligand of G-quadruplex DNA Structures
  18. 20498
    “…Furthermore, the CNS, but not the RG, promoter is targeted by the canonical hypoxia response involving HIF1A. Importantly, the transactivation by HIF1A is modulated by the size of the GT polymorphism. …”
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    The Expression of CNS-Specific PPARGC1A Transcripts Is Regulated by Hypoxia and a Variable GT Repeat Polymorphism
  19. 20499
    “…And these genes participate in the canonical pathway of regulation of the Epithelial-Mesenchymal and the biological functions of apoptosis, growth of tumor and cell proliferation of tumor cell lines. …”
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    Identification of differentially expressed miRNAs in differentiating benign from malignant pleural effusion
  20. 20500
    “…Ecotype Simulation 2 was used to predict putative ecotypes (ecologically distinct populations), and their membership, and canonical correspondence analysis was used to examine the geographical and geochemical bases for variation in their distribution. …”
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    Biogeography of American Northwest Hot Spring A/B′-Lineage Synechococcus Populations
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