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  1. 20601
    “…Moreover, GDF11 inhibited the production of matrix metalloproteinase (MMP)‐2, 3, 9 in aortic SMCs. The canonical TGF‐β (Smad2/3) signalling was enhanced by GDF11, while its inhibition suppressed the inhibitory effects of GDF11 on SMC de‐differentiation and MMP production in vitro. …”
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    GDF11 prevents the formation of thoracic aortic dissection in mice: Promotion of contractile transition of aortic SMCs
  2. 20602
    “…Comparisons of brain activation during the task were assessed in a whole‐brain, voxel‐wise analysis, contrasting congruent, and incongruent conditions. The canonical regions of the frontoparietal, salience, dorsal attention, and default mode networks were used as seed regions for assessing functional connectivity within and between large‐scale brain networks. …”
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    Inhibition of emotions in healthy aging: age‐related differences in brain network connectivity
  3. 20603
    “…In addition to its canonical functions, vitamin D has been proposed to be an important mediator of the immune system. …”
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    Immunomodulatory Effects of Vitamin D Supplementation in a Deficient Population
  4. 20604
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    On the origins of American Criollo pigs: A common genetic background with a lasting Iberian signature
  5. 20605
    por Cavieres-Lepe, Javier, Ewer, John
    Publicado 2021
    “…In particular, we examine findings related to the oscillations in intracellular Ca(2+) levels in circadian pacemakers and how they are regulated by canonical clock genes, neuropeptides, and light stimuli. …”
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    Reciprocal Relationship Between Calcium Signaling and Circadian Clocks: Implications for Calcium Homeostasis, Clock Function, and Therapeutics
  6. 20606
    “…This protective activity of carnosine was not mediated by modulation of the canonical inflammatory pathway but instead can be explained by the well-known antioxidant and free-radical scavenging activities of carnosine, enhanced macrophage phagocytic activity, and the rescue of fractalkine receptor CX3CR1. …”
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    Carnosine Protects Macrophages against the Toxicity of Aβ1-42 Oligomers by Decreasing Oxidative Stress
  7. 20607
    “…Canonical Wnt/β-catenin (cWnt) signaling is a crucial regulator of development and Dishevelled (Dsh/Dvl) functions as an integral part of this pathway by linking Wnt binding to the Frizzled:LRP5/6 receptor complex with β-catenin-stimulated gene expression. …”
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    The nanoscale organization of the Wnt signaling integrator Dishevelled in the vegetal cortex domain of an egg and early embryo
  8. 20608
    “…After binding to its receptor, Ang II elicits Ca(2+) influx into cells, mediated by TRPC5 and TRPC6 (transient receptor potential canonical type 5 and 6). Clemizole and La(3+) salts have been shown to block TRPC channels in vitro, and we therefore tested their potential effect on Ang II‐induced glomerular hyperpermeability. …”
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    Clemizole and La(3+) salts ameliorate angiotensin II‐induced glomerular hyperpermeability in vivo
  9. 20609
    “…Histology was described using a four-point scale. We performed canonical discrimination analysis (CDA) to determine the structural level where differences between treatments occurred and mixed effects regression to estimate effect sizes. …”
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    A randomized controlled trial comparing non-steroidal anti-inflammatory and fusion protein inhibitors singly and in combination on the histopathology of bovine respiratory syncytial virus infection
  10. 20610
    “…Human TRIM7 contains the canonical TRIM motif and a B30.2 domain at the C terminus. …”
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    Crystal structure and mutational analysis of the human TRIM7 B30.2 domain provide insights into the molecular basis of its binding to glycogenin-1
  11. 20611
    “…Interestingly, loci found in this Filipino population cohort were mostly independent from the canonical vitamin D synthesis and metabolism pathways. …”
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    Next Generation Sequencing of 502 Lifestyle and Nutrition related Genetic Polymorphisms reveals Independent Loci for Low Serum 25-hydroxyvitamin D Levels among Adult Respondents of the 2013 Philippine National Nutrition Survey*
  12. 20612
    “…METHODS: OCTA images of the optic nerve and macular area were obtained using a Canon-HS100 OCT device for 48 participants (48 eyes). …”
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    Enhanced Visualization of Retinal Microvasculature via Deep Learning on OCTA Image Quality
  13. 20613
    “…Furthermore, the interactions among the p53 family members which could modulate normal functions of the canonical p53 in tumor tissue are described. Lastly, we emphasize the importance of clinical studies to assess the significance of combining the deregulation of different members of the p53 family to define the outcome of the disease.…”
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    p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies
  14. 20614
    “…A significant down-regulation in bcl2 and p53 genes was observed in treated cells compared to non-treated cells (p < 0.05), suggesting that MA1 may not follow the canonical pathway to induce apoptosis in ovarian cancer cell lines. …”
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    Malformin-A1 (MA1) Sensitizes Chemoresistant Ovarian Cancer Cells to Cisplatin-Induced Apoptosis
  15. 20615
    “…Combined LDH activity and LDHB/LDHA expression analysis intimated various heterotetrameric isoforms comprising LDHA and LDHB in tumor cells, not only canonical LDHA. Millimolar concentrations of exogenous pyruvate induced substrate inhibition of LDH activity in both enzymatic assays ex vivo and in live cells, abrogated glycolytic ECAR, and inhibited hyperpolarized [1-(13)C]pyruvate-to-[1-(13)C]lactate conversion rates in cellulo. …”
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    Excess exogenous pyruvate inhibits lactate dehydrogenase activity in live cells in an MCT1-dependent manner
  16. 20616
    “…These compounds also inhibited caspase-4 production associated with non-canonical NLRP3 inflammasome activation. These results show for the first time that certain chalcones could interrupt the activation of the NLRP3 inflammasome in H. pylori-infected THP-1 cells. …”
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    Interruption of Helicobacter pylori-Induced NLRP3 Inflammasome Activation by Chalcone Derivatives
  17. 20617
    “…We show that adaptation to iron-deprivation induces upregulation of TfR, a cohort of parasite-specific genes (ESAG3, PAGS), genes involved in glucose uptake and glycolysis (THT1 and hexokinase), endocytosis (Phosphatidic Acid Phosphatase, PAP2), and most notably a divergent RNA binding protein RBP5, indicative of a non-canonical mechanism for regulating intracellular iron levels. …”
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    Novel aspects of iron homeostasis in pathogenic bloodstream form Trypanosoma brucei
  18. 20618
    “…Many of the differential expressed genes are related to canonical pathways of the FECD pathogenesis, such as extracellular matrix reorganization and immunological response. …”
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    Incorporating Differential Gene Expression Analysis with Predictive Biomarkers to Identify Novel Therapeutic Drugs for Fuchs Endothelial Corneal Dystrophy
  19. 20619
    “…Moreover, we show that canonical NF-κB signaling is involved in IRF1 induction and that the TBK1/IKKε inhibitor BX795, but not siTBK1 treatment, impairs HMPV-induced phosphorylation of the NF-κB subunit p65. …”
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    Human Metapneumovirus Induces IRF1 via TANK-Binding Kinase 1 and Type I IFN
  20. 20620
    por Biswas, Anushua, Narlikar, Leelavati
    Publicado 2021
    “…Further, ExoDiversity discovers small nucleotide variations within and outside canonical motifs, which co-occur with variations in footprints, suggesting that the TF-DNA structural configuration at those regions is likely to be different. …”
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    Resolving diverse protein–DNA footprints from exonuclease-based ChIP experiments
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