“…In this context, hMutLγ is further stimulated by a co-dependent activity of pro-crossover factors hEXO1 and hMutSγ, the latter of which binds HJs(11). hMutLγ also specifically binds a variety of branched DNAs, including HJs, but canonical resolvase activity is not observed implying that the endonuclease incises adjacent to junction branch points to effect resolution. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Analysis of CJPI-1 revealed two canonical VgrG homologues, CJ488_0978 and CJ488_0998, harbouring distinct C-termini in a genetically variable region downstream of the T6SS operon. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…PZA-R departing from this canonical scenario is poorly understood. Here, we genotyped pncA and purported alternative PZA-R genes (panD, rpsA, and clpC1) with long-read sequencing of 19 phenotypically PZA-monoresistant isolates collected in Sweden and compared their phylogenetic and genomic characteristics to a large set of MDR PZA-R (MDR(PZA-R)) isolates. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Pulsatile stretch ameliorates the hypoxic UPR response, and while increasing presence of autophagosomes, does not activate canonical autophagy signaling pathways. We propose that simultaneous application of hypoxia and graded levels of cyclic stretch can be used to distinguish myocyte signaling in the deformable pulmonary artery of early PPHN, versus the inflexible late stage PPHN artery.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Prediction of the effect of a single-nucleotide variant (SNV) in an intronic region on aberrant pre-mRNA splicing is challenging except for an SNV affecting the canonical GU/AG splice sites (ss). To predict pathogenicity of SNVs at intronic positions −50 (Int-50) to −3 (Int-3) close to the 3’ ss, we developed light gradient boosting machine (LightGBM)-based IntSplice2 models using pathogenic SNVs in the human gene mutation database (HGMD) and ClinVar and common SNVs in dbSNP with 0.01 ≤ minor allelic frequency (MAF) < 0.50. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In this article, we present SynthSR, a method to train a CNN that receives one or more scans with spaced slices, acquired with different contrast, resolution and orientation, and produces an isotropic scan of canonical contrast (typically a 1 mm MP-RAGE). The presented method does not require any preprocessing, beyond rigid coregistration of the input scans. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…What is most striking is that the canonical language network appears to be just one of multiple similarly organized, differentially specialized distributed networks that populate the evolutionarily expanded zones of human association cortex. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The data shows that the peptide binds to the same region of NRP1 that is used by the SARS-CoV-2 virus for cell entry, however, via a non-canonical binding mode. Our results provide evidence for a non-standard NRP1 binding motif, while also providing a basis for further engineering of ClTx to generate peptides with improved NRP1 binding for future biomedical applications.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…By performing grand canonical Monte Carlo simulations, we investigated the influence of the metal type on the CO(2)/H(2) and CO(2)/CH(4) separation performances of these 32 M-MOFs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Following genome sequencing, several bioinformatic algorithms were developed to map G4s in vitro based on a canonical sequence motif, G-richness and G-skewness or alternatively sequence features including k-mers, and more recently machine/deep learning. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Clustering of the corresponding sequence motifs using a neighbor-joining algorithm strongly suggests that canonical Inr+DPE promoters could be common to metazoan species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The pathological hallmark of ACM is fibro-adipocytes replacing cardiac myocytes. The canonical WNT pathway is implicated in the pathogenesis of ACM. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The secondary structure of tRNAs shows that all the tRNAs can be folded into canonical clover-leaf secondary structures, except three trnW, trnG, and trnC. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Considering all of the experimental results together, the effects of PT-2385 on ionic currents demonstrated herein could be non-canonical and tend to be upstream of the inhibition of HIF-2α. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Our analysis identified six genes as risk factors for predicting metastatic status by LASSO regression, including zinc finger BED-Type Containing 2 (ZBED2), S100 calcium-binding protein A2 (S100A2), Jagged canonical Notch ligand 1 (JAG1), laminin subunit gamma 2 (LAMC2), transglutaminase 2 (TGM2), and the transcription factor hepatic leukemia factor (HLF). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, this neglects the complex metabolic pathways involved in vitamin D bioactivity, including two canonical forms D3 and D2, bioactive 1,25-dihydroxy metabolites and inactive 24-hydroxy and other metabolites. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…It is plausible that the increased Id1 and/or absence of ID4 result in changes in interactions with bHLH canonical clock components or with targets upstream and/or downstream of the clock, thereby resulting in abnormal properties of the circadian clock and its entrainment.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: SLC4A11 does not contain canonical N-terminal mitochondrial targeting sequences. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We use the standard power spectral density analysis (PSDA) and canonical correlation analysis (CCA) feature extraction methods on one dataset and show that the current approach outperforms most of the related studies on this dataset. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso