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  1. 20641
    “…Previous studies have confirmed that the combination of ensemble empirical mode decomposition (EEMD) and canonical correlation analysis (CCA) can effectively suppress EMG artifacts. …”
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    A Fast Approach to Removing Muscle Artifacts for EEG with Signal Serialization Based Ensemble Empirical Mode Decomposition
  2. 20642
    “…The presence of two non-canonical domains in H-CA8f’s BGC may contribute to adding chemical diversity to this family of NPs. …”
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    Rhodococcus comparative genomics reveals a phylogenomic-dependent non-ribosomal peptide synthetase distribution: insights into biosynthetic gene cluster connection to an orphan metabolite
  3. 20643
    por Kazyken, D., Lentz, S.I., Fingar, D.C.
    Publicado 2021
    “…Alkaline pHi also activates AMPK, a canonical sensor of energetic stress. Functionally, alkaline pHi activates AMPK-mTOR signaling, which attenuates apoptosis caused by growth factor withdrawal. …”
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    Alkaline intracellular pH (pHi) activates AMPK–mTORC2 signaling to promote cell survival during growth factor limitation
  4. 20644
    “…Several inhibitors regulate Wnt canonical pathways like Dickkopf-related protein-1 (Dkk-1) and sclerostin. …”
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    Relation of Wnt Signaling Pathway Inhibitors (Sclerostin and Dickkopf-1) to Left Ventricular Mass Index in Maintenance Hemodialysis Patients
  5. 20645
    “…Functional pathway analysis suggested that JQ1 was acting directly on the transcriptional level of IFN-response genes and not via the canonical JAK/STAT pathway. This was in line with JQ1 modulated expression and BRD4 and Pol II occupancy at IFN-signature genes, supporting a direct mechanistic interaction. …”
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    BET inhibitors repress expression of interferon-stimulated genes and synergize with HDAC inhibitors in glioblastoma
  6. 20646
    por Feng, Fang, Han, Huiqin, Wu, Shuqi, Wang, Hui
    Publicado 2021
    “…This results in a promigration tumorigenic phenotype independent of canonical TSHR-Gα(S) signaling that regulates the expression of molecules involved in iodine uptake and metabolism. …”
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    Crosstalk Between Abnormal TSHR Signaling Activation and PTEN/PI3K in the Dedifferentiation of Thyroid Cancer Cells
  7. 20647
    “…This review will focus substantially on the canonical Hh signaling and the treatment strategies employed in different studies, with special emphasis on the molecular mechanisms and combination treatment in regard to Hh inhibitors and chemotherapeutics. …”
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    Defining the Role of GLI/Hedgehog Signaling in Chemoresistance: Implications in Therapeutic Approaches
  8. 20648
    “…We first demonstrated, in NIH3T3 mouse fibroblasts, the ability of this kinase of controlling primary ciliogenesis and canonical HH signaling. Next, we took advantage of transformed human medulloblastoma cells belonging to the SHH-driven subtype, i.e., DAOY and ONS-76 cells, to ascertain the role for MAPK15 in HH-mediated cellular transformation. …”
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    MAPK15 Controls Hedgehog Signaling in Medulloblastoma Cells by Regulating Primary Ciliogenesis
  9. 20649
    “…Also, a dynamic learning strategy is applied to the canonical methodology to improve the exploitation capability. …”
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    Rank-driven salp swarm algorithm with orthogonal opposition-based learning for global optimization
  10. 20650
    “…Their active site H-cluster is formed of a canonical [4Fe-4S] cluster ([4Fe-4S](H)) covalently attached to a unique [2Fe] subcluster ([2Fe](H)), where both sites are redox active. …”
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    The Nonphysiological Reductant Sodium Dithionite and [FeFe] Hydrogenase: Influence on the Enzyme Mechanism
  11. 20651
    “…Shared truncating variants (frameshift, non-sense, and canonical splice variants) were considered likely pathogenic when loss-of-function was a known mechanism of disease. …”
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    A Protocol for Preconceptional Screening of Consanguineous Couples Using Whole Exome Sequencing
  12. 20652
    “…Methods: We infect female C57BL/6 and Per1/2-null mice which have a disrupted canonical (transcription translation feedback loop, TTFL) clock with 1×10 (5) red blood cells containing P. chabaudi (DK genotype). …”
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    Synchrony between daily rhythms of malaria parasites and hosts is driven by an essential amino acid
  13. 20653
    “…Published 80 host response genes reported to be modulated in BMVECs following SARS-CoV-2 S protein binding were used to identify key canonical pathways and intermediate molecules mediating the regulation of APP production following the attachment of S protein to endothelial cells. …”
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    Network Meta-analysis on the Changes of Amyloid Precursor Protein Expression Following SARS-CoV-2 Infection
  14. 20654
    “…Even weaker signals and non-canonical steroid ligands can activate AR in the presence of truncated AR-splice variants, AR overexpression, or activating mutations in AR. …”
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    Androgen Receptor Signaling in Prostate Cancer and Therapeutic Strategies
  15. 20655
    “…This modification typically causes proteins to associate with the membrane and allows them to participate in signaling pathways. In the canonical understanding of FTase, the isoprenoids are attached to the cysteine residue of a four-amino-acid CaaX box sequence. …”
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    MALDI-MS Analysis of Peptide Libraries Expands the Scope of Substrates for Farnesyltransferase
  16. 20656
    “…It is integral to several signalling cascades, notably downstream of non-canonical Wnt and mitogen activated protein kinase (MAPK) signalling pathways. …”
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    JNK Mediates Differentiation, Cell Polarity and Apoptosis During Amphioxus Development by Regulating Actin Cytoskeleton Dynamics and ERK Signalling
  17. 20657
    “…SIMPLE SUMMARY: The pyramidal neurons of rat prefrontal cortex express potassium channels identified as a non-canonical splice variant of the TREK-2 channel. The main function of TREK channels is to regulate the resting membrane potential. …”
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    Activity of TREK-2-like Channels in the Pyramidal Neurons of Rat Medial Prefrontal Cortex Depends on Cytoplasmic Calcium
  18. 20658
    “…The new GEM produces all canonical amino acids, and its phenotypic predictions are consistent with laboratory data. …”
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    High-Quality Genome-Scale Reconstruction of Corynebacterium glutamicum ATCC 13032
  19. 20659
    “…However, microorganisms have an abundance of active compounds ranging from sugar molecules, enzymes, canonical membrane proteins, reductase enzymes (NADH and NADPH), membrane proteins to many more. …”
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    Marine Macroalgae Display Bioreductant Efficacy for Fabricating Metallic Nanoparticles: Intra/Extracellular Mechanism and Potential Biomedical Applications
  20. 20660
    “…Sclerostin is secreted by osteocytes and inhibits the canonical pathway by binding to LRP5/6, thereby suppressing bone formation. …”
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    Antitumor Effect of Sclerostin against Osteosarcoma
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