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  1. 20681
    “…Motility suppressors and gene co-occurrence analyses reveal co-evolutionary linkages between MotV, a subset of non-canonical CheV proteins and flagellar C-ring components FliG and FliM, whereas MotW regulatory inputs appear to intersect with specific c-di-GMP signaling pathways. …”
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    Analysis of HubP-dependent cell pole protein targeting in Vibrio cholerae uncovers novel motility regulators
  2. 20682
    “…Anterior and posterior segment photographs were collected via iPhone 5 C camera and a Canon non-mydriatic fundus camera, respectively. …”
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    Effectiveness of a telemedicine program for triage and diagnosis of emergent ophthalmic conditions
  3. 20683
    por Bar Yaacov, Dan
    Publicado 2022
    “…As a first step to address this question, we identified ADAR1 and ADAR2 homologs in the planarian Schmidtea mediterranea, which is evolutionarily distant from canonical lab models (e.g., flies and nematodes). Our results indicate that knockdown of either planarian adar1 or adar2 by RNA interference (RNAi) resulted in upregulation of dsRNA-response genes, including three planarian rig-I-like receptor (prlr) homologs. …”
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    Functional analysis of ADARs in planarians supports a bilaterian ancestral role in suppressing double-stranded RNA-response
  4. 20684
    “…CONCLUSION: Our results showed that SCRG1 promotes chondrogenic differentiation of UCMSCs by inhibiting canonical Wnt/β-catenin signaling through Wnt5a. Our findings provide a future target for chondrogenic differentiation and cartilage regeneration.…”
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    Scrapie-Responsive Gene 1 Promotes Chondrogenic Differentiation of Umbilical Cord Mesenchymal Stem Cells via Wnt5a
  5. 20685
    “…Summary statement: Non-neuronal cells in the vertebrate retina, Muller glial cells, express non-canonical photopigments and sense blue light causing calcium release from intracellular stores strongly suggesting a novel intrinsic photosensitivity and new regulatory events mediating light-driven processes with yet unknown physiological implications.…”
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    The Intrinsic Blue Light Responses of Avian Müller Glial Cells Imply Calcium Release from Internal Stores
  6. 20686
    “…These mutations could arise from the stabilization of mismatches, in the active site of polymerases, in conformations involving minor tautomers that are indistinguishable from canonical base pairs. In this review, we discuss the evidence for tautomerism in DNA, and its consequences to the fidelity of DNA replication. …”
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    Structural Insights Into Tautomeric Dynamics in Nucleic Acids and in Antiviral Nucleoside Analogs
  7. 20687
    “…Mechanistically, KDM1A down-regulates two antagonists of the canonical Wnt pathway, APC2 and DKK1, by demethylating H3K4me1/2 of the APC2 promoter region and the nonhistone substrate HIF-1α, resulting in the inhibition of APC2 transcription and the activation of the HIF-1α/microRNA-146a/DKK1 axis. …”
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    KDM1A promotes thyroid cancer progression and maintains stemness through the Wnt/β-catenin signaling pathway
  8. 20688
    “…U-RT1 Western blot analyses showed phosphorylation of IκB as well as IKK, indicating a constitutively active canonical NF-кB pathway. This was further supported by the significant reduction in cell viability and CYLD cleavage products after CARD9 siRNA knockdown. …”
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    CARD9 Forms an Alternative CBM Complex in Richter Syndrome
  9. 20689
    “…Dysregulation of the Wnt canonical pathway, and its key mediator β-catenin, has been shown to be important for the evolution of MM and the acquisition of drug resistance, making it a potentially attractive therapeutic target. …”
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    Combination of Histone Deacetylase Inhibitor Panobinostat (LBH589) with β-Catenin Inhibitor Tegavivint (BC2059) Exerts Significant Anti-Myeloma Activity Both In Vitro and In Vivo
  10. 20690
    “…Extensive molecular analyses including a cDNA array and expression analyses of the specific gene targets demonstrated that such activities are mediated through their effect on cell adhesion/tight junction proteins (Claudins, E-cadherin), inhibition of canonical Wnt/β-catenin signaling pathways and the consequent downregulation of EMT-signaling proteins (Vimentin, MMPs, VEGF and VEGFR) that play a critical role in cancer metastasis. …”
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    A Low Dose Combination of Withaferin A and Caffeic Acid Phenethyl Ester Possesses Anti-Metastatic Potential In Vitro: Molecular Targets and Mechanisms
  11. 20691
    “…Collectively, apart from its canonical action on I(Na) inhibition, LCS was effective at altering the amplitude, gating, and hysteresis of I(K(A)) in excitable cells. …”
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    Evidence for Inhibitory Perturbations on the Amplitude, Gating, and Hysteresis of A-Type Potassium Current, Produced by Lacosamide, a Functionalized Amino Acid with Anticonvulsant Properties
  12. 20692
    por Cheng, Chu-Han, Chen, Li-Ru, Chen, Kuo-Hu
    Publicado 2022
    “…On the other hand, excessive glucocorticoids interfere the canonical BMP pathway and inhibit Wnt protein production, causing mesenchymal progenitor cells to differentiate toward adipocytes rather than osteoblasts. …”
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    Osteoporosis Due to Hormone Imbalance: An Overview of the Effects of Estrogen Deficiency and Glucocorticoid Overuse on Bone Turnover
  13. 20693
    “…We found a regulated Ca(2+) entry pathway in PT cells via the apical transient receptor potential canonical 3 (TRPC3) channel, which initiates transcellular Ca(2+) transport. …”
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    Hypercalciuria switches Ca(2+) signaling in proximal tubular cells, induces oxidative damage to promote calcium nephrolithiasis
  14. 20694
    “…We proposed that the different kinetics of FMN loss during RET is due to the presence of brain-specific long 50 kDa isoform of the NDUFV3 subunit of complex I, which is absent in the heart where only the canonical 10 kDa short isoform is found. Our simulation studies suggest that the long NDUFV3 isoform can reach toward the FMN binding pocket and affect the nucleotide affinity to the apoenzyme. …”
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    Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart
  15. 20695
    “…In the predominant circulating recombinant form (CRF) 02_AG (CRF02_AG), 27 canonical DRMs and 29 NOPs significantly increased or decreased in RT during cART scale-up, whereas in IN, no DRM and only seven NOPs significantly changed. …”
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    Antiretroviral Imprints and Genomic Plasticity of HIV-1 pol in Non-clade B: Implications for Treatment
  16. 20696
    “…Further, Notch signaling depletion via the canonical pathway showed mitochondrial fragmentation and loss of differentiation similar to Opa1 depletion. …”
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    Mitochondrial fusion regulates proliferation and differentiation in the type II neuroblast lineage in Drosophila
  17. 20697
    por Aslam, Naveed, Alvi, Farah
    Publicado 2022
    “…Canonical transient receptor potential channels (TRPC3) may play a pivotal role in the development and viability of dendritic arbor in Purkinje neurons. …”
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    TRPC3 Channel Activity and Viability of Purkinje Neurons can be Regulated by a Local Signalosome
  18. 20698
    “…In thermogenic brown and brite adipocytes, lipolysis stimulation is the canonical way for the activation of non-shivering thermogenesis. …”
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    The Molecular Brakes of Adipose Tissue Lipolysis
  19. 20699
    “…The Qaseem location revealed the highest values of most soil parameters, while the Jizan location showed the lowest. The canonical correspondence analysis (CCA) showed that the community structure and diversity are mainly affected by the soil salinity and moisture. …”
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    Vegetation Composition of the Halophytic Grass Aeluropus lagopoides Communities within Coastal and Inland Sabkhas of Saudi Arabia
  20. 20700
    “…We are talking about a defect in the canonical signaling pathway (Wnt/β-catenin), which regulates the expression of genes-activators of osteoblastogenesis, dissociation of the stages of physiological bone remodeling.In addition to congenital bilateral or unilateral aplasia of the vas deferens, an increase in the frequency of CFTR mutations is also found in non-obstructive azoospermia, oligo-, astheno- and teratospermia. …”
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    Муковисцидоз как полиэндокринное заболевание (обзор литературы)
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