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  1. 20701
    “…Patients with PTSD canonically demonstrate an increased risk for inflammatory diseases as well as increased sympathetic tone and norepinephrine outflow. …”
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    Splenic Denervation Attenuates Repeated Social Defeat Stress-Induced T Lymphocyte Inflammation
  2. 20702
    “…A cumulative risk score for each woman based on the unstandardised canonical coefficients was obtained by the discriminant equation. …”
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    Estimating the Risk of Maternal Death at Admission: A Predictive Model from a 5-Year Case Reference Study in Northern Uganda
  3. 20703
    “…K-Cl transporter KCC2 is an important regulator of neuronal development and neuronal function at maturity. Through its canonical transporter role, KCC2 maintains inhibitory responses mediated by γ-aminobutyric acid (GABA) type A receptors. …”
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    Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons
  4. 20704
    “…By utilizing CRISPR-Cas9 gene edited CASP4/1, NLRP3 KO and ASC-def cells, caspase-4 activation was found to be independent of the canonical NLRP3 inflammasomes. In CRISPR-Cas9 gene edited CASP1 macrophages, caspase-4 activation was significantly up regulated that enhanced the enzymatic cleavage of GSDMD at the same cleavage site as caspase-1 to induce GSDMD pore formation and sustained bioactive IL-1β secretion. …”
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    The colonic pathogen Entamoeba histolytica activates caspase-4/1 that cleaves the pore-forming protein gasdermin D to regulate IL-1β secretion
  5. 20705
    “…Holdase-type extracellular chaperone activity plays a putative non-canonical role for PAI-2. Our data demonstrate that glycosylated PAI-2 more efficiently inhibits the aggregation of Alzheimer’s disease and preeclampsia-associated amyloid beta peptide (Aβ), compared to non-glycosylated PAI-2 in vitro. …”
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    A Novel Role for Plasminogen Activator Inhibitor Type-2 as a Hypochlorite-Resistant Serine Protease Inhibitor and Holdase Chaperone
  6. 20706
    “…Natterin is a potent pro-inflammatory fish molecule, inducing local and systemic IL-1β/IL-1R1-dependent neutrophilia mediated by non-canonical NLRP6 and NLRC4 inflammasome activation in mice, independent of NLRP3. …”
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    Natterin-Induced Neutrophilia Is Dependent on cGAS/STING Activation via Type I IFN Signaling Pathway
  7. 20707
    “…The results of morphometrical measurements of bulls reared at Masha wereda had wider (P < 0.05) values for their pelvic width and the Chest Depth for the bulls aged ≥7 years was higher (P < 0.01). While the canon bone circumference was also wider when compared to the bulls reared at Anderacha wereda. …”
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    Assessment of indigenous Shaka cattle structural indices reared in Shaka zone, south west Ethiopia
  8. 20708
    “…This counter-intuitive finding may indicate that canonical effector CD8+ T cells are less prevalent in COVID-19 patients than healthy controls. …”
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    Determining clinically relevant features in cytometry data using persistent homology
  9. 20709
    “…This amino acid substitution occurs near the angiotensin-converting enzyme 2 (ACE2)-binding interface and gives rise to a canonical RGD adhesion motif that is often found in native extracellular matrix proteins, including fibronectin. …”
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    Receptor binding domain of SARS-CoV-2 is a functional αv-integrin agonist
  10. 20710
    “…In this work, we characterized the three Blue Light sensing Using FAD (BLUF) domain-containing proteins encoded in the A. nosocomialis genome, which account for the only canonical light sensors present in this microorganism. …”
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    Characterization of BLUF-photoreceptors present in Acinetobacter nosocomialis
  11. 20711
    “…Results: Notably, with β-catenin stabilization in CD34-expressing cells and potential activation of canonical Wnt signaling, the mutant mice showed a brief increase of hair density in the short term, but over time leads to a senescence phenotype developing premature canities and thinning [hair follicle (HF) miniaturization]. …”
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    β-Catenin Signaling Evokes Hair Follicle Senescence by Accelerating the Differentiation of Hair Follicle Mesenchymal Progenitors
  12. 20712
    “…Moreover, the resistance provided by ARGs compared to canonical mutations in the glyphosate target enzyme, EPSPS, remains unclear. …”
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    A Glyphosate-Based Herbicide Cross-Selects for Antibiotic Resistance Genes in Bacterioplankton Communities
  13. 20713
    “…The study was carried out on a General Electric Discovery W750 3T magnetic resonance tomograph, a Canon Aquilion One multispiral X-ray computed tomograph (Gadovist 7.5 ml, Yomeron 400 mg−50 ml). …”
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    Multiparametric MR Imaging Features of Primary CNS Lymphomas
  14. 20714
    “…Almost all HBG2-expessing cells also express HBB, suggesting bi-allelic expression in single RBC from the HBG2/HBB loci, and we annotated another cluster as reticulocytes based on canonical gene expression. Additional RBC clusters were also annotated based on the enriched expression of NIX, ACVR2B and HEMGN, previously shown to be involved in erythropoiesis. …”
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    Single Cell RNA-Seq Analysis of Human Red Cells
  15. 20715
    “…Suppression of translation is a canonical response to stressful changes in the cellular environment. …”
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    Differential translation elongation directs protein synthesis in response to acute glucose deprivation in yeast
  16. 20716
    “…CdiA–CT(EC869) interacts with domain II of Tu, thereby preventing the 3′-moiety of tRNA to bind to Tu as in canonical Tu:GTP:aa-tRNA complexes. Superimposition of the Tu:GTP:aa-tRNA structure onto the CdiA–CT(EC869):Tu structure suggests that the 3′-portion of tRNA relocates into the CdiA–CT(EC869) active site, located on the opposite side to the CdiA–CT(EC869) :Tu interface, for tRNA cleavage. …”
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    Mechanistic insights into tRNA cleavage by a contact-dependent growth inhibitor protein and translation factors
  17. 20717
    “…The interaction of MB and MG with the LDH surface was further investigated in dry and aqueous solution using Grand canonical Monte Carlo and molecular dynamics simulations. …”
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    Gamma radiation as a green method to enhance the dielectric behaviour, magnetization, antibacterial activity and dye removal capacity of Co–Fe LDH nanosheets
  18. 20718
    “…The effects of (H(2)O)(n) (n = 1–3) clusters on the HO(2) + NH(2) → NH(3) + (3)O(2) reaction have been investigated by employing high-level quantum chemical calculations with M06-2X and CCSD(T) theoretical methods, and canonical variational transition (CVT) state theory with small curvature tunneling (SCT) correction. …”
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    Catalytic effect of (H(2)O)(n) (n = 1–3) on the HO(2) + NH(2) → NH(3) + (3)O(2) reaction under tropospheric conditions
  19. 20719
    “…This indicates a conserved role for GlRac and GlActin in forming membrane protrusions, despite the absence of canonical actin binding proteins that link Rho GTPase signaling to lamellipodia formation. …”
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    The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment
  20. 20720
    “…Gas permeabilities of COFs were computed by combining the results of grand canonical Monte Carlo (GCMC) and molecular dynamics (MD) simulations, and many COF membranes were found to overcome the upper bound of polymeric membranes for He/H(2), N(2)/CH(4), H(2)/N(2), He/CH(4), H(2)/CH(4), and He/N(2) separations. …”
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    High-Throughput Screening of COF Membranes and COF/Polymer MMMs for Helium Separation and Hydrogen Purification
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