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  1. 20801
    “…However, most existing methods register LSM data with existing canonical atlases, e.g., The Allen Brain Atlas (ABA), which have been generated from tissue that has been distorted by removal from the skull, fixation and physical handling. …”
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    Restoring morphology of light sheet microscopy data based on magnetic resonance histology
  2. 20802
    “…The climatic conditions of each sample were organized and analyzed in RStudio with the raster package and in SPSS with Pearson’s Canonical Correlation Analysis (CCA), respectively. …”
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    Exploring the Ecological Preferences and Essential Oil Variability in Wild-Growing Populations of the Endangered Local Greek Endemic Thymus holosericeus (Lamiaceae)
  3. 20803
    “…The treatment choices for this malignancy have been confined to conventional chemotherapeutic agents, due to a lack of expression of the canonical molecular targets. Immunotherapy has been recently changing the treatment paradigm for many types of tumors, and the approach of evoking active immune responses in the milieu of breast tumors through cancer vaccines has been introduced as one of the most novel immunotherapeutic approaches. …”
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    Cancer Vaccines for Triple-Negative Breast Cancer: A Systematic Review
  4. 20804
    “…METHOD: Clustering data were from 1094 individuals with major depressive disorder in the last 6 months and measures of 149 metabolites from a (1)H-NMR platform and 30 depressive symptoms (IDS-SR30). Canonical correlation analyses (CCA) were used to identify main independent metabolite-symptom axes of variance. …”
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    Metabolomics dissection of depression heterogeneity and related cardiometabolic risk
  5. 20805
    “…PRL binds to its receptor PRLR, which belongs to a superfamily of the class I cytokine receptor that has no intrinsic kinase activity. In canonical signaling, PRL binding to PRLR induces downstream signaling including JAK-STAT, AKT and MAPK pathways. …”
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    Prolactin receptor signaling: A novel target for cancer treatment - Exploring anti-PRLR signaling strategies
  6. 20806
    “…Here, in an effort to improve MMP specificity, we incorporated the metal-binding non-canonical amino acids (NCAAs), 3,4-dihydroxyphenylalanine (L-DOPA) and (8-hydroxyquinolin-3-yl)alanine (HqAla), into the MMP-inhibitory N-terminal domain of TIMP2 (N-TIMP2) at selected positions that interact with the catalytic Zn(2+) ion (S2, S69, A70, L100) or with a structural Ca(2+) ion (Y36). …”
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    Utilizing genetic code expansion to modify N-TIMP2 specificity towards MMP-2, MMP-9, and MMP-14
  7. 20807
    por Huang, Qingyao, Baudis, Michael
    Publicado 2023
    “…Confirmed by differential expression analysis of data from corresponding cancer types, the results show that for most cancer types, despite dissimilarity of their CND landscapes, similar canonical pathways are affected. In 25 analyses of 17 cancer types, we have identified 19 to 169 significant genes by copy deletion, including RB1, PTEN and CDKN2A as the most significantly deleted genes among all cancer types. …”
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    Candidate targets of copy number deletion events across 17 cancer types
  8. 20808
    “…The two copies of hRev7 tethered by the two hRev3-RBMs form a symmetric head-to-head dimer through the canonical HORMA dimerization interface. Recent cryo-EM structures reveal that Saccharomyces cerevisiae Polζ (scPolζ) also includes two copies of scRev7 bound to distinct regions of scRev3. …”
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    Evolution of Rev7 interactions in eukaryotic TLS DNA polymerase Polζ
  9. 20809
    “…Furthermore, the motion of biomolecules may not be well described by a single, canonical random walk model. Here, we develop a two-step statistical testing scheme for comparing biomolecule dynamics observed in different experimental conditions without having to identify or make strong prior assumptions about the model generating the recorded random walks. …”
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    Simulation-based inference for non-parametric statistical comparison of biomolecule dynamics
  10. 20810
    “…Although the VP is canonically considered a relay and output structure for this circuit, emerging data indicate that the VP is a central hub in an extensive network for reward processing and the regulation of motivation that extends beyond classically defined basal ganglia borders. …”
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    Ventral pallidal regulation of motivated behaviors and reinforcement
  11. 20811
    “…CONCLUSIONS: Normal Bactrian camel plasma-derived exosomes may inhibit the growth of HCC cells through regulating pathways of Ras, Ras-Association Proximate 1 (Rap1), phosphoinositide 3-kinase-protein kinase B (PI3K-Akt), mitogen-activated protein kinase (MAPK), adenosine monophosphate-activated protein kinase (AMPK), and canonical Wnt signaling pathways.…”
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    Effects of plasma-derived exosomes from the normal and thin Bactrian camels on hepatocellular carcinoma and their differences at transcriptome and proteomics levels
  12. 20812
    “…K-means cluster analysis was then used to screen out proteins that continuously increased/decreased with age. Canonical signaling pathways that were activated or inhibited in bone tissue along with increasing age were identified by Ingenuity Pathway Analysis (IPA). …”
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    Inflammation produced by senescent osteocytes mediates age-related bone loss
  13. 20813
    “…The widespread use of molecular diagnosis, made easier by next generation sequencing technology, now allows very early confirmation of clinical diagnosis, even in the case of non-canonical presentation of the disorder with other overlapping conditions. …”
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    Neurofibromatosis Type 1: Pediatric Aspects and Review of Genotype–Phenotype Correlations
  14. 20814
    “…The parent genes of differentially expressed circRNA were mainly enriched in some Gene Ontology (GO) terms and pathways related to cashmere fiber traits, such as the canonical Wnt signaling pathway, which is involved in the regulation of cell promotion, stem cell proliferation, Wnt signaling pathway regulation, epithelial morphogenesis, MAPK signaling pathway, and cell adhesion molecules pathway. …”
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    Identification and Characterization of Circular RNAs (circRNAs) Using RNA-Seq in Two Breeds of Cashmere Goats
  15. 20815
    “…However, different from the LDLR, a canonical target of PCSK9, the C-terminal CHRD domain of PCSK9 is dispensable for the PCSK9-induced degradation of ACE2. …”
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    SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-to-Cell Fusion via Activation of SREBP-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2
  16. 20816
    “…Mutations inactivating canonical RNAi lead to rampant transposition and insertional inactivation of targets resulting in antimicrobial drug resistance. …”
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    Heterochromatin and RNAi act independently to ensure genome stability in Mucorales human fungal pathogens
  17. 20817
    “…Lactate operates via covalent binding and canonical signaling, redox change, and lactylation of DNA. …”
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    Lactate as a myokine and exerkine: drivers and signals of physiology and metabolism
  18. 20818
    “…The PII superfamily consists of widespread signal transduction proteins found in all domains of life. In addition to canonical PII proteins involved in C/N sensing, structurally similar PII-like proteins evolved to fulfill diverse, yet poorly understood cellular functions. …”
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    Carbon signaling protein SbtB possesses atypical redox-regulated apyrase activity to facilitate regulation of bicarbonate transporter SbtA
  19. 20819
    por Miller, Stephen A.
    Publicado 2023
    “…This long covalent bond theory (LCBT) relocates one-third of Earth’s valence electrons and indicates that non-canonical O-O bonds play a subtle, but crucial role in the structure and stability of Earth’s most abundant material.…”
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    The location of the chemical bond. Application of long covalent bond theory to the structure of silica
  20. 20820
    “…Using high frequency probe and a Canon Aplio i800 machine, ultrasonographers took scans of nail plates of the hands from healthy subjects. …”
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    Systematic study on nail plate assessment: differences in nail plate shape, thickness, power Doppler signal and scanning approach
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