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  1. 20901
    “…Importantly, we show that only the cytoplasmic isoform QKI-7 promotes poly(A) tail extension, and that it does so by recruiting the non-canonical poly(A) polymerase PAPD4 through its unique carboxyl-terminal region. …”
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    The STAR protein QKI-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs
  2. 20902
    “…The increased regional and distant metastasis observed in HER2+ tumors with high levels of ITGB6 might be mediated by the canonical Rho–Rac pathway through increased expression of MMP9 and MMP15.…”
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    High expression of integrin β6 in association with the Rho–Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers
  3. 20903
    “…Due to the existence of several protein (and messenger RNA (mRNA)) isoforms, these mutations were stratified, using the protein sequence which is considered canonical. This approach showed that there is an urgent need for the uniformed positioning of currently known EZH2 mutations (somatic—in tumors, as well as germline mutations in the Weaver’s syndrome). …”
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    Polycomb repressive complex’s evolutionary conserved function: the role of EZH2 status and cellular background
  4. 20904
    “…BACKGROUND: The Cell Ontology (CL) is an OBO Foundry candidate ontology covering the domain of canonical, natural biological cell types. Since its inception in 2005, the CL has undergone multiple rounds of revision and expansion, most notably in its representation of hematopoietic cells. …”
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    The Cell Ontology 2016: enhanced content, modularization, and ontology interoperability
  5. 20905
    “…We provide mechanistic evidence for an interplay between E2F7 and the canonical E2F factors E2F1-3 in the regulation of multiple miRNAs. …”
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    E2F7 regulates transcription and maturation of multiple microRNAs to restrain cell proliferation
  6. 20906
    “…The full-length Liv-AdipoR (1,245 bp) encoded a protein that exhibited the canonical seven transmembrane domains (7TMs) and the inversed topology that characterize members of the progestin and adipoQ receptor (PAQR) family. …”
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    Molecular characterization of an adiponectin receptor homolog in the white leg shrimp, Litopenaeus vannamei
  7. 20907
    “…We found that Wnt signaling is transiently upregulated in the acute stage of disease, consistent with a timely induction of canonical Wnt ligands. The enhancement of signaling coincided with hippocampal neuronal damage and local expression of immune cytokines such as TNFα and IFNγ, implicating the role of the inflammatory milieu in activation of the Wnt/β-catenin pathway. …”
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    Activation of Wnt signaling promotes hippocampal neurogenesis in experimental autoimmune encephalomyelitis
  8. 20908
    por Sun, Y, Zhu, D, Chen, F, Qian, M, Wei, H, Chen, W, Xu, J
    Publicado 2016
    “…Instead of directly altering canonical Wnt signaling, SFRP2 augments β-catenin activities initiated by WNT16B, another soluble factor from DNA-damaged stroma. …”
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    SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment
  9. 20909
    “…This gene set was enriched for miR-34b/c binding sites, functional categories related to the central nervous system, such as axon guidance or neuron differentiation, and serotonin biosynthesis and signaling canonical pathways. Our results provide preliminary evidence for the contribution to ADHD of a functional variant in the pri-miR-34b/c promoter, possibly through dysregulation of the expression of mature forms of miR-34b and miR-34c and some target genes. …”
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    Preliminary evidence for association of genetic variants in pri-miR-34b/c and abnormal miR-34c expression with attention deficit and hyperactivity disorder
  10. 20910
    “…Pupal weight was positively correlated with larval survival and was negatively correlated with developmental time for polyphagous species. Canonical correspondence analysis of the relationship between fruit nutrient composition and tephritid survival showed that polyphagous species survived better than oligophagous ones in fruits containing higher concentrations of carbohydrate, fibre, and lipid. …”
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    Host plant range of a fruit fly community (Diptera: Tephritidae): does fruit composition influence larval performance?
  11. 20911
    “…Several unique chromatin features were present in rice BDPs but were missing from unidirectional promoters (UDPs), including overrepresented active histone marks, canonical nucleosomes and underrepresented H3K27me3. …”
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    Histone modifications facilitate the coexpression of bidirectional promoters in rice
  12. 20912
    por Forstner, A J, Hofmann, A, Maaser, A, Sumer, S, Khudayberdiev, S, Mühleisen, T W, Leber, M, Schulze, T G, Strohmaier, J, Degenhardt, F, Treutlein, J, Mattheisen, M, Schumacher, J, Breuer, R, Meier, S, Herms, S, Hoffmann, P, Lacour, A, Witt, S H, Reif, A, Müller-Myhsok, B, Lucae, S, Maier, W, Schwarz, M, Vedder, H, Kammerer-Ciernioch, J, Pfennig, A, Bauer, M, Hautzinger, M, Moebus, S, Priebe, L, Sivalingam, S, Verhaert, A, Schulz, H, Czerski, P M, Hauser, J, Lissowska, J, Szeszenia-Dabrowska, N, Brennan, P, McKay, J D, Wright, A, Mitchell, P B, Fullerton, J M, Schofield, P R, Montgomery, G W, Medland, S E, Gordon, S D, Martin, N G, Krasnov, V, Chuchalin, A, Babadjanova, G, Pantelejeva, G, Abramova, L I, Tiganov, A S, Polonikov, A, Khusnutdinova, E, Alda, M, Cruceanu, C, Rouleau, G A, Turecki, G, Laprise, C, Rivas, F, Mayoral, F, Kogevinas, M, Grigoroiu-Serbanescu, M, Propping, P, Becker, T, Rietschel, M, Cichon, S, Schratt, G, Nöthen, M M
    Publicado 2015
    “…Target gene and pathway analyses revealed 18 significant canonical pathways, including brain development and neuron projection. …”
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    Genome-wide analysis implicates microRNAs and their target genes in the development of bipolar disorder
  13. 20913
    “…METHODS: We introduce CC-PROMISE as an integrated data analysis method that combines components of canonical correlation (CC) and projection onto the most interesting evidence (PROMISE). …”
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    CC-PROMISE effectively integrates two forms of molecular data with multiple biologically related endpoints
  14. 20914
    por Wang, L, Wu, F, Song, Y, Li, X, Wu, Q, Duan, Y, Jin, Z
    Publicado 2016
    “…FoxO1 increased bone formation of pPDLSCs by competing with TCF-4 for β-catenin and inhibiting the canonical Wnt pathway. Finally, inflammation increases miR-182 expression through the nuclear factor-κB pathway, and the miR-182 overexpression in the inflammatory microenvironment resulted in an imbalance in the lncRNA-POIR-miR-182 regulatory network. …”
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    Long noncoding RNA related to periodontitis interacts with miR-182 to upregulate osteogenic differentiation in periodontal mesenchymal stem cells of periodontitis patients
  15. 20915
    “…Enrichment analysis of differentially expressed genes demonstrated that “NFAT in cardiac hypertrophy” pathway was not only one of the significant associated canonical pathways, but also the only one predicted with a non-zero score of 1.34 (i.e. activated) through Ingenuity Pathway Analysis molecule activity predictor. …”
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    Exploring Regulatory Mechanisms of Atrial Myocyte Hypertrophy of Mitral Regurgitation through Gene Expression Profiling Analysis: Role of NFAT in Cardiac Hypertrophy
  16. 20916
    “…We monitored the real-time changes in proliferation of Huh7 hepatocellular carcinoma and A7r5 vascular smooth muscle cells with different initial seeding densities following transient receptor potential canonical 1 (TRPC1) silencing using xCELLigence system. …”
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    Effects of cell seeding density on real-time monitoring of anti-proliferative effects of transient gene silencing
  17. 20917
    “…Membrane HYAL-2 degrades HA bound by co-receptor CD44. Also, in a non-canonical signal pathway, HYAL-2 serves as a receptor for transforming growth factor beta (TGF-β) to signal with downstream tumor suppressors WWOX and SMAD4 to control gene transcription. …”
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    HYAL-2–WWOX–SMAD4 Signaling in Cell Death and Anticancer Response
  18. 20918
    “…The residues within Did2(176–204) helix α6′ in the interface make up of an amino acid sequence as E(192)′xxL(195)′xxR(198)′L(199)′xxL(202)′R(203)′, identical to type 1 MIT-interacting motif (MIM1) (D/E)xxLxxRLxxL(K/R) of CHMP1A(180–196) observed in Vps4-CHMP1A complex structure, indicating that Did2 binds to Vta1NTD through canonical MIM1 interactions. Moreover, the Did2 binding does not result in Vta1NTD significant conformational changes, revealing that Did2, similar to Vps60, enhances Vta1 stimulation of Vps4 ATPase activity in an indirect manner.…”
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    NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway
  19. 20919
    “…Unexpectedly, we found a number of putative sugar binding proteins that are associated with prokaryotic uptake systems; and approximately 100 class C G-protein coupled receptors (GPCRs) with non-canonical putative sugar binding domains. CONCLUSIONS: We report the first comprehensive characterization of the membrane protein machinery of biotechnologically relevant anaerobic gut fungi. …”
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    Mapping the membrane proteome of anaerobic gut fungi identifies a wealth of carbohydrate binding proteins and transporters
  20. 20920
    “…All rate constants, computed by canonical variational transition state theory (CVT) with the small-curvature tunneling correction (SCT), are in reasonable agreement with the limited experimental data. …”
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    Theoretical insight into OH- and Cl-initiated oxidation of CF(3)OCH(CF(3))(2) and CF(3)OCF(2)CF(2)H & fate of CF(3)OC(X•)(CF(3))(2) and CF(3)OCF(2)CF(2)X• radicals (X=O, O(2))
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