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  1. 21001
    “…Through functional analysis over the canonical pathways and gene ontologies, we identified significantly enriched pathways in 143 AS genes including immune system, mRNA splicing-major pathway, and nonsense-mediated decay, which may be important to carcinogenesis in HCC risk factors. …”
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    Differential alternative splicing regulation among hepatocellular carcinoma with different risk factors
  2. 21002
    “…Based on RNA sequencing analysis several components of the canonical nuclear factor (NF)-κB pathway, especially those related to NF-κB inhibition, were expressed more highly in unresponsive cases. …”
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    Responsiveness of chronic lymphocytic leukemia cells to B-cell receptor stimulation is associated with low expression of regulatory molecules of the nuclear factor-κB pathway
  3. 21003
    “…Furthermore, the elincRNAs and canonical lincRNAs exhibit distinct genomic features, and elincRNAs have the higher CGI enrichment and lower sequence conservation. …”
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    A Novel Approach to Identify Enhancer lincRNAs by Integrating Genome, Epigenome, and Regulatome
  4. 21004
    “…Neither this long CAG embedded mRNA nor short polyCAG RNA could induce interferon pathway genes or cause apoptosis. polyQ-TBP induced the expression of canonical RNA sensors but the downstream transcription factor, IRF3, showed a muted response. …”
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    Interferon mediated neuroinflammation in polyglutamine disease is not caused by RNA toxicity
  5. 21005
    “…A detailed investigation of infection of VA1, a member of the non-canonical HAstV-VA/HMO clade, showed robust replication in HIE derived from different patients and from different intestinal regions independent of the cellular differentiation status. …”
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    Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape
  6. 21006
    “…Genetic complementation assays established that the deficient phenotype was rescued by the canonical version of FBXL4, confirming the pathological nature of the variants. …”
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    Molecular Characterization of New FBXL4 Mutations in Patients With mtDNA Depletion Syndrome
  7. 21007
    “…In this pathway, mannonate generated by the initial reactions of the canonical isomerase pathway is converted to 6-phosphogluconate by two novel biochemical reactions, catalyzed by a mannonate kinase and a 6-phosphomannonate 2-epimerase. …”
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    A Novel D-Galacturonate Fermentation Pathway in Lactobacillus suebicus Links Initial Reactions of the Galacturonate-Isomerase Route With the Phosphoketolase Pathway
  8. 21008
    “…TGFβ1 induced the phosphorylation of canonical proteins Smad2/3, which was ECM scaffold-dependent. …”
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    Cirrhotic Human Liver Extracellular Matrix 3D Scaffolds Promote Smad-Dependent TGF-β1 Epithelial Mesenchymal Transition
  9. 21009
    “…We defined PTVs as variants that lead to a premature stop, disrupt canonical splice-sites, or lead to insertions/deletions that shift reading frame. …”
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    Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease
  10. 21010
    “…The uncontrolled spread of information on Twitter can both stimulate discussions on non-official and non-canonical channels of communication and provide uncontrolled influencing of diverse stakeholders. …”
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    European Society for Medical Oncology (ESMO) 2018 Congress Twitter analysis: from ethics to results through the understanding of communication and interaction flows
  11. 21011
    “…Low self-esteem subjects also displayed an enhanced volatility in reported feelings of self-worth, and this was linked to an increased tendency for social prediction errors to determine momentary self-worth. Canonical correlation analysis revealed that individual differences in self-esteem related to several interconnected psychiatric symptoms organized around a single dimension of interpersonal vulnerability. …”
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    Neurocomputational mechanisms underpinning aberrant social learning in young adults with low self-esteem
  12. 21012
    “…The suspicious B. anthracis isolates were identified using conventional methods and PCR, followed by genotyping using multiple-locus variable-number tandem repeats (VNTRs) analysis (MLVA-15) and canonical single-nucleotide polymorphism (canSNP). …”
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    Epidemiological Investigation and Etiological Analysis of a Cutaneous Anthrax Epidemic Caused by Butchering Sick Cattle in Guizhou, China
  13. 21013
    “…The Methanosarcina mazei pyrrolysyl-tRNA synthetase (PylRS)⋅tRNA(Pyl) pair can be used to incorporate non-canonical amino acids (ncAAs) into proteins at installed amber stop codons. …”
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    Linker and N-Terminal Domain Engineering of Pyrrolysyl-tRNA Synthetase for Substrate Range Shifting and Activity Enhancement
  14. 21014
    “…The results show the following. (1) Herbal medicines regulate both the mitochondrial apoptosis pathway and death receptor apoptosis pathway. (2) Herbal medicines modulate the above two apoptotic pathways by affecting signal transductions of IL-6/STAT3, MAPK/NF-κ B, Oxidative stress, Non-canonical TGF-β1, WNT/β-catenin, and Cell cycle, thereby ameliorating CAC. …”
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    Apoptosis Exerts a Vital Role in the Treatment of Colitis-Associated Cancer by Herbal Medicine
  15. 21015
    “…We particularly highlight the usage of internal ribosomal entry site sequences for more efficient protein production, and also the significance of site-specific incorporation of non-canonical amino acids for labeling applications and creation of antibody drug conjugates using cell-free systems. …”
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    Cell-Free Protein Synthesis: A Promising Option for Future Drug Development
  16. 21016
    por Zhang, Wei, Liu, Miao, Li, Chunlin
    Publicado 2020
    “…A total of 272 samples were collected from different land use areas within the study area to estimate the concentration levels, spatial distributions and potential sources of arsenic (As), cadmium (Cd), chromium (Cr), copper (Cu), mercury (Hg), nickel (Ni), lead (Pb) and zinc (Zn) with a geographic information system (GIS), principal component analysis (PCA) and canonical correspondence analysis (CCA). Only the concentration of Cd was over the national standard value (GB 15618–2018). …”
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    Soil heavy metal contamination assessment in the Hun-Taizi River watershed, China
  17. 21017
    “…While Frs2 homologues were detected only in members of the Bilateria, canonical Dof sequences (containing Dof, ankyrin, and SH2/SH3 domains) were present in cnidarians as well as bilaterians (but not in other animals or holozoans), correlating with the appearance of FGFR. …”
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    What lies beneath: Hydra provides cnidarian perspectives into the evolution of FGFR docking proteins
  18. 21018
    “…Downregulated chemokine expression could be mainly due to the inhibition of canonical NFκB signaling based on DEG in the signaling pathways and transcription factor binding sites predicted from the proximal promoters. …”
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    Mechanisms of Maintenance of Foot-and-Mouth Disease Virus Persistence Inferred From Genes Differentially Expressed in Nasopharyngeal Epithelia of Virus Carriers and Non-carriers
  19. 21019
    “…Proteins involved in blood coagulation and complement/coagulation cascades represented a greater fraction of the differentiating proteins in CBS(−/−) patients (51%) than in Cbs(−/−) mice (21%). Top canonical pathways, identified by Ingenuity Pathways Analysis, such as LXR/RXR, FXR/RXR activation (− log[P-value] = 30–31) and atherosclerosis signaling (− log[P-value] = 10–11) were similarly affected in Cbs(−/−) mice and CBS(−/−) humans. …”
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    Cystathionine β-synthase deficiency: different changes in proteomes of thrombosis-resistant Cbs(−/−) mice and thrombosis-prone CBS(−/−) humans
  20. 21020
    “…This study examined the dynamic temporal functional association of heart rate variability (HRV) with the interaction between three main canonical brain networks in 38 healthy male subjects at rest and directly after a psychosocial stress task. …”
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    Heart Rate Variability as an Index of Differential Brain Dynamics at Rest and After Acute Stress Induction
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