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  1. 21141
    “…Photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) analysis using endogenously tagged CPEB4 in HeLa cells reveals that CPEB4 preferentially binds to the 3′UTR of immediate early gene mRNAs, at G-containing variants of the canonical U- and A-rich CPE located in close proximity to poly(A) sites. …”
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    Control of immediate early gene expression by CPEB4-repressor complex-mediated mRNA degradation
  2. 21142
    por Mair, Nina K., Hale, Benjamin G.
    Publicado 2022
    “…While loss-of-function (LOF) mutations in canonical JAK-STAT signaling genes (such as IFNAR2, TYK2, STAT1, STAT2 and IRF9) have previously been characterized, little is known about the consequences of mutations in other human factors required for IFN signaling. …”
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    Ultra-Rare BRD9 Loss-of-Function Variants Limit the Antiviral Action of Interferon
  3. 21143
    “…The net photosynthetic rate of annual plants was significantly higher than that of perennial plants (P < 0.05), and there was a significant correlation between leaf phenotypic and photosynthetic traits (P < 0.05). Canonical correspondence analysis showed that soil water content and available phosphorus were the main factors affecting the leaf function of dominant species, indicating that hydrologic factors were still important environmental factors affecting leaf functional traits of dominant species in the WLFZ. …”
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    Responses of leaf functional traits to different hydrological regimes and leaf economics spectrum in the water level fluctuation zone of Three Gorges Reservoir, China
  4. 21144
    “…In non-cancer tissue, ΔNp63(+) cells are atypical KRT19(+) duct cells that overall lack SOX9 expression while they do express canonical basal markers and pertain to a niche of cells expressing gastrointestinal stem cell markers. 3D views show that the basal cells anchor on the basal membrane of normal medium to large ducts while in CP they exist in multilayer dome-like structures. …”
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    Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease
  5. 21145
    “…This suggests that AOC3 may have an important role in atherosclerosis independent of its canonical inflammatory effect. The dual role of AOC3 impacts therapeutic strategies using pharmacological regulators of SSAO activity.…”
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    Increased atherosclerotic plaque in AOC3 knock-out in ApoE(−/−) mice and characterization of AOC3 in atherosclerotic human coronary arteries
  6. 21146
    “…Using data from the UK Biobank (N = 6389), we applied canonical correlation analysis to estimate associations between the amplitude and connectivity strength of subnetworks of three major neurocognitive networks (default mode, DMN; salience, SN; central executive networks, CEN) with accelerometer-derived measures of physical activity and self-reported mental health measures (primarily of depression, anxiety disorders, neuroticism, subjective well-being, and risk-taking behaviors). …”
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    Shared brain and genetic architectures between mental health and physical activity
  7. 21147
    “…Linear ubiquitin chains regulate canonical NF-κB activation and cell death. Single nucleotide polymorphisms in RNF31, such as Q584H and Q622L, are known to cause the activated B cell-like subtype of diffuse large B cell lymphoma (ABC-DLBCL) because of enhanced LUBAC-mediated NF-κB activation. …”
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    Identification and molecular analysis of RNF31 Q622H germline polymorphism
  8. 21148
    por Singh, Surabhi, Tapadia, Madhu G.
    Publicado 2022
    “…Sustained, rather than a transient expression of JNK leads to excessive production of Anti-Microbial Peptides without involving the canonical transcription factors of the Toll or IMD pathways, NF-κB. …”
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    Ayurvedic formulations Guduchi and Madhuyashti triggers JNK signaling mediated immune response and adversely affects Huntington phenotype
  9. 21149
    “…G protein‐coupled receptors (GPCRs) are important drug targets characterized by a canonical seven transmembrane (TM) helix architecture. …”
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    Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures
  10. 21150
    “…This endeavour may help in exploring novel non-canonical therapeutic strategies to COVID-19 disease and associated complications.…”
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    Pathophysiological involvement of host mitochondria in SARS-CoV-2 infection that causes COVID-19: a comprehensive evidential insight
  11. 21151
    “…Mechanistically, Tbc1d10c suppressed CD8 T-cell activation and anti-tumor function by intersecting canonical NF-κB pathway activation via regulation of Map3k3-mediated IKKβ phosphorylation. …”
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    Tbc1d10c is a selective, constitutive suppressor of the CD8 T-cell anti-tumor response
  12. 21152
    “…The Frizzled receptors FZD1, FZD4 and FZD6 were significantly upregulated in EOBRCA, suggesting activation of non-canonical WNT signaling. Our data, suggest the implication of TGM3 deletion in early breast cancer onset. …”
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    Molecular characterization of early breast cancer onset to understand disease phenotypes in African patients
  13. 21153
    “…Unbiased proteomics analysis reveals surprising increases in many insoluble proteins predominantly originating from mitochondria and perturbing multiple canonical biological pathways as assessed by ingenuity pathway analysis, including neurodegenerative disease-associated proteins such as tau, cofilin, SOD1 and DJ-1. …”
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    Pathological characterization of a novel mouse model expressing the PD-linked CHCHD2-T61I mutation
  14. 21154
    “…The best‐established signaling pathways for the β(2)AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway. …”
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    Fusion of the β(2)‐adrenergic receptor with either Gαs or βarrestin‐2 produces constitutive signaling by each pathway and induces gain‐of‐function in BEAS‐2B cells
  15. 21155
    “…METHODS: We combined large-scale brain resting-state networks (RSNs) approaches with canonical correlation analysis to explore the accumulating effects of lipid gene- and protein-centric levels on cerebrospinal fluid (CSF) biomarkers, dynamic trajectory of large-scale RSNs, and cognitive performance across entire AD spectrum. …”
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    Dyslipidemia induced large-scale network connectivity abnormality facilitates cognitive decline in the Alzheimer’s disease
  16. 21156
    “…Identification of alterations in DNA methylation plays an important role in the diagnosis and understanding of the etiology of those disorders. Canonical pipelines for the detection of differentially methylated regions (DMRs) usually rely on inter-group (e.g., case versus control) comparisons. …”
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    Identification of differentially methylated regions in rare diseases from a single-patient perspective
  17. 21157
    “…Transient receptor potential canonical channel 1 (TRPC1) is a important target for myocardial injury treatment. …”
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    Screening of rosmarinic acid from Salvia miltiorrhizae acting on the novel target TRPC1 based on the ‘homology modelling–virtual screening–molecular docking–affinity assay–activity evaluation’ method
  18. 21158
    “…YAP1-KLF5 association further promoted TEAD-mediated transcriptional program independently of canonical Hippo kinases, which eventually gave rise to the enhanced cancer stemness and metastasis. …”
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    Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer stemness and metastasis in triple-negative breast cancer
  19. 21159
    “…[Image: see text] CXCL10 is a pro-inflammatory chemokine produced by the host in response to microbial infection. In addition to canonical, receptor-dependent actions affecting immune-cell migration and activation, CXCL10 has also been found to directly kill a broad range of pathogenic bacteria. …”
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    Disparate Regions of the Human Chemokine CXCL10 Exhibit Broad-Spectrum Antimicrobial Activity against Biodefense and Antibiotic-Resistant Bacterial Pathogens
  20. 21160
    “…Acute HCV infection incites evidence of immune activation and canonical antiviral responses in the human host even in the presence of systemic immunosuppression. …”
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    Transcriptional responses define dysregulated immune activation in Hepatitis C (HCV)-naïve recipients of HCV-infected donor kidneys
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