“…Although agonist binding promotes canonical G protein signalling transmitted through conformational changes, G protein-coupled receptors also interact with other proteins. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…For 182 patients, photos taken with the EyeGo system were compared to images taken by existing clinic cameras: a BX 900 slit-lamp with a Canon EOS 40D Digital Camera and an FF 450 plus Fundus Camera with VISUPAC™ Digital Imaging System. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Wnt antagonism with FJ9 increases MeCP2 protein degradation in cultured HSC, and FJ9-mediated loss of MeCP2 is rescued by leupeptin but not by proteasome and lysozome inhibitors. In conclusion, canonical Wnt pathway increases MeCP2 protein due to protein stability which in turn represses Ppar-γ and activates HSC.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, the presence of a (Zn)(2)-cacodylate complex in our second crystal form induces ligand swapping within the canonical His(4) zinc binding motif, thereby creating two new Zn-sites, one of which involves residues from symmetry-related molecules. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We previously showed tri and tetra peptides which were derived from the canonical -CxxC- motif of the Trx1-active site, called thioredoxin mimetic (TXM) peptides, reversed inflammatory and oxidative stress damage mimicking Trx1 activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Previously, we identified the Focal-adhesion kinase canonical pathway as a major contributor of resistance to estrogen deprivation and cellular-sarcoma kinase (c-src) as a dominant gene in this pathway. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Despite recent advances in understanding macrophage activation, little is known regarding how human alveolar macrophages in health calibrate its transcriptional response to canonical TLR4 activation. In this study, we examined the full spectrum of LPS activation and determined whether the transcriptomic profile of human alveolar macrophages is distinguished by a TIR-domain-containing adapter-inducing interferon-β (TRIF)-dominant type I interferon signature. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, lower bacterial richness but higher fungal richness were displayed, markedly differences in bacterial communities but highly similarities in fungal communities were exhibited, during MTSSF process comparatively to the LTSSF process. Canonical correspondence analysis revealed microbial structure transition happened at thermophilic stages under environmental stress of moisture, pH, acidity, and pile temperature. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…While Rb loss induced canonical E2f targets, unexpectedly p107 loss did not further induce these genes but instead caused post-transcriptional Skp2-induction and Cdk2 activation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We propose a modification of the PGL score method that replaces the use of a canonical pathway with custom gene lists organized into three tiers with descending levels of evidence combined with the utilization of single nucleotide polymorphism (SNP) causality prediction methods. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Recently we showed that upon transfer of growing Mycobacterium smegmatis into saline, the bacilli exited the canonical cell division cycle and formed septated multi-nucleoided cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Consistent with the canonically active conformation of its protein tyrosine phosphate-binding loop (PTP loop) observed in the structure, the phosphatase assay results demonstrated that DUSP26-N has significantly higher catalytic activity than DUSP26-C. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…A set of genes involved in acetate utilization provides a canonical example. These results leave open the possibility of developing strain-specific antibiotic treatments targeting such differentially essential genes, but suggest that such opportunities may be rare in closely related bacteria. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Both principal component analysis and neighbor-joining tree analysis showed that ILs with a higher PGG displayed greater genetic diversity. Canonical discriminant analysis identified six phenotypic traits (plant height, yield per plant, filled grain percentage, panicle length, panicle number and days to flowering) as the main discriminatory traits among the ILs and between the subpopulations and showed significant phenotypic distances between subpopulations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Inactive ERK5 resides in the cytosol, forming a complex with Hsp90-Cdc37 superchaperone. In a canonical mechanism, MEK5-dependent activation results in ERK5 C-terminal autophosphorylation, Hsp90 dissociation, and nuclear translocation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Geitlerinema has the canonical gene for sulfide quinone reductase (SQR) used in cyanobacterial AP and a putative transcriptional regulatory gene in the same operon. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Here we show that the canonical RBPjk-dependent Notch signaling cascade controls PlexinD1 expression in primary endothelial and cancer cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Of these, we confirmed nuclear factor kappa B (NF-κB) subunit RelA, as a novel direct target of miR-7-5p in melanoma cells, such that miR-7-5p suppresses NF-κB activity to decrease expression of canonical NF-κB target genes, including IL-1β, IL-6 and IL-8. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Importantly, this finding indicates that age-dependent changes in cortical structure may differ among functionally distinct zones within larger canonical cortical areas. Likely relationships to known age-related declines in visual performance are discussed to provide direction for future research in this area.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…When subjected to starvation conditions, cells of M. smegmatis exit from the canonical cell division cycle, segregate and compact their chromosomes, and become septated and multi-nucleoided. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso