“…These actions appear to be transduced by multiple direct and indirect GCG receptor (GCGR)-dependent mechanisms. Although the canonical GCGR is expressed in brown adipose tissue (BAT) the importance of BAT GCGR activity for the physiological control of body weight, or the response to GCG agonism, has not been defined. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVE: Sclerostin is a canonical Wingless (Wnt)/β-catenin signaling pathway inhibitor and had been associated with high arterial stiffness in patients with chronic kidney disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Intra-and inter-judge reliability among four independent judges was computed on a total of 503 speaking turns coded through Cohen’s κ and Krippendorff’s canonical agreement coefficients (Cc), respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Pharmacological inhibition of canonical ALK5-mediated signaling abrogated physoxia-induced COL2A1 and PAI-1 expression. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Glutamate substitution of the A55 residue Ile-48, adjacent to the canonical φX(D/E) Cul3-binding motif, reduced affinity of A55BB for Cul3–NTD by at least 2 orders of magnitude. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…NEW & NOTEWORTHY Recent evidence has emerged that canonical large-scale networks such as the “default network” fractionate into parallel distributed networks when defined within individuals. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…These pathways flank or bypass the canonical adenosinergic pathway subjected to the conversion of ATP by CD39. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Furthermore, rAceyCP1 serum IgG responders had canonical Th2-specific recall responses (IL4, IL5, IL13) in splenocytes stimulated ex vivo. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…While the vast majority of these enzymes display broad activity toward canonical dNTPs, such as the dNTPase SAMHD1 that blocks reverse transcription of retroviruses in macrophages by maintaining dNTP pools at low levels, Escherichia coli (Ec)-dGTPase is the only known enzyme that specifically hydrolyzes dGTP. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Gene expression analysis revealed that oxLDL induced the expression of Wnt3A in macrophages, a key activator of canonical Wnt signaling pathways. In addition, western blot analysis showed that the macrophage conditioned media further enhanced the reduction of phosphorylated β-catenin induced by oxLDL. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: The chromobox (CBX) proteins CBX2, CBX4, CBX6, CBX7, and CBX8, also known as Polycomb (Pc) proteins, are canonical components of the Polycomb repressive complex 1 (PRC1). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Therefore, noncanonical gene expression patterns of cardiac maturation may be sufficient to direct functional maturation of cardiomyocytes, with canonical gene expression patterns being insufficient to temporally define cardiac subtypes of in vitro differentiation.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Interestingly, pathway analyses of gene expression profiles revealed NF-κB and HIF signaling as top networks of these genes, cellular functions and canonical pathways influencing the activity of PT against tumor cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Membership and composition of microbiomes were analyzed using nonmetric multidimensional scaling and canonical correlation analysis (CCA). The contribution of various bacterial communities of the mother-infant dyad to both milk and infant fecal bacterial communities were estimated using SourceTracker2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Then, we performed the same experiments with THs and Bex in presence of the inhibitor of the non-canonical THs membrane receptor integrin αVβ3, cilengitide. …”
Enlace del recurso
Enlace del recurso

“…Furthermore, we show that concatemers formed from new tetrameric α-10-β-α-β and α-10-β-α-γ constructs also assemble in both orientations with free subunits to give canonical αβγ receptors. To restrict linker flexibility, we systematically shorten linker lengths of dimeric and pentameric constructs and find optimized constructs that direct the assembly of GABA(A)Rs only in one orientation, thus eliminating the ambiguity associated with previously described concatemers. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We recently reported that Tax-1 and Tax-2 form complexes with the TNF-receptor associated factor 3, TRAF3, a negative regulator of the non-canonical NF-κB pathway. The NF-κB pathway is constitutively activated by the Tax proteins, whereas it is inhibited by HBZ and APH-2. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The major dominant Symbiodiniaceae types were C1 in the HC and the HR, C1/Cspc/C50/C15 and D1 in the IR, and C3u and C15 in the LR. Canonical correspondence analysis showed that the relative abundance of different Symbiodiniaceae types is affected by multiple environmental factors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In spite of this growth, academics in low income settings struggle to gain access to the full canon of research literature. While the vast majority of open access repositories and funding organizations with open access policies are based in high income countries, the geographic patterns of open access publication itself are not well characterized. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso