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  1. 21821
    “…Hierarchical clustering, principal component analysis (PCA), and canonical correlation analysis assigned 21 cannabis varieties into three chemotypes using the content and ratio of cannabinoids, terpenoids, flavonoids, sterols, and triterpenoids across inflorescences, leaves, stem bark, and roots. …”
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    Identification of Chemotypic Markers in Three Chemotype Categories of Cannabis Using Secondary Metabolites Profiled in Inflorescences, Leaves, Stem Bark, and Roots
  2. 21822
    “…Therefore, the presents study investigated the expression of Notch4, delta-like canonical Notch ligand 4 (Dll4) and related factors in an in vivo rat model and in rat pulmonary microvascular endothelial cells (PMVECs) in vitro, to study the mechanisms by which intrauterine infection affects rat lung development. …”
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    Effect of the Notch4/Dll4 signaling pathway in early gestational intrauterine infection on lung development
  3. 21823
    “…Altogether, this work uncovers a non-canonical function of ETCI in controlling CD39 and PD-L1 immune checkpoints, thereby improving the anti-tumor response in AML.…”
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    Disrupting Mitochondrial Electron Transfer Chain Complex I Decreases Immune Checkpoints in Murine and Human Acute Myeloid Leukemic Cells
  4. 21824
    “…In this paper we study how information flows in a canonical motif that mimics a cortico-thalamo-cortical circuit composed by three mutually coupled neuronal populations (also called the V-motif). …”
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    Information Transmission in Delay-Coupled Neuronal Circuits in the Presence of a Relay Population
  5. 21825
    “…We report the first evidence both for canonical vsiRNA production during wild-type Nodamura virus infection and direct vsiRNA sequestration by its RNAi suppressor protein B2 in two strains of suckling mice. …”
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    Efficient Dicer processing of virus-derived double-stranded RNAs and its modulation by RIG-I-like receptor LGP2
  6. 21826
    “…METHODS: ATF4 protein levels and expression of canonical gene targets were analyzed in the liver following fasting and physiological feeding in the presence or absence of the mTORC1 inhibitor, rapamycin. …”
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    Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin
  7. 21827
    “…Nevertheless, the periodic unwinding caused by the nonisostericity of A…A with the flanking canonical base pairs in d(CAG)(5).d(CAG)(5) distorts the regular B-form geometry. …”
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    Conformational distortions induced by periodically recurring A…A in d(CAG).d(CAG) provide stereochemical rationale for the trapping of MSH2.MSH3 in polyQ disorders
  8. 21828
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    Radiation therapy with curative intention in men with de novo metastatic prostate carcinoma: shoot‘em all!
  9. 21829
    “…To exclude the contribution of canonical macroautophagy in LC3II accumulation, experiments were performed using U1810 cells lacking ATG13, a key enzyme of macroautophagy. …”
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    Receptor-Mediated Mitophagy Rescues Cancer Cells under Hypoxic Conditions
  10. 21830
    “…Our results suggest that published reference compounds including 7,8-DHF do not activate TrkB, consistent with canonical dogma, which indicates that the reported pharmacological activity of these compounds should be interpreted carefully in a broad functional context.…”
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    Do Small Molecules Activate the TrkB Receptor in the Same Manner as BDNF? Limitations of Published TrkB Low Molecular Agonists and Screening for Novel TrkB Orthosteric Agonists
  11. 21831
    “…The HMM observations are sequences of spectral power in seven canonical frequency bands between 0 to 50 Hz, where power is averaged within each band and scaled between 0 and 1. …”
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    A hidden Markov model reliably characterizes ketamine-induced spectral dynamics in macaque local field potentials and human electroencephalograms
  12. 21832
    “…Over 70% of researchers endorsed Morgan’s canon as a useful principle but many caveated this in their free-text responses. …”
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    The hidden side of animal cognition research: Scientists’ attitudes toward bias, replicability and scientific practice
  13. 21833
    “…Therefore, we searched for and identified two canonical GXSXG lipase motifs within BB0562, despite the lack of homology to known bacterial lipases. …”
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    BB0562 is a nutritional virulence determinant with lipase activity important for Borrelia burgdorferi infection and survival in fatty acid deficient environments
  14. 21834
    “…We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the parietal cortex in male adult mice. …”
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    Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury
  15. 21835
    “…Ten commonly used training-free spatial filtering methods, i.e., native combination (single-electrode), bipolar combination, Laplacian combination, average combination, common average reference (CAR), minimum energy combination (MEC), maximum contrast combination (MCC), canonical correlation analysis (CCA), multivariate synchronization index (MSI), and partial least squares (PLS), were compared for multielectrode signals combination in SSVEP visual acuity assessment by statistical analyses, e.g., Bland–Altman analysis and repeated-measures ANOVA. …”
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    Enhancing Performance of SSVEP-Based Visual Acuity via Spatial Filtering
  16. 21836
    “…In this work, we followed a multiscale computational approach to unlock both the adsorption- and membrane-based CH(4)/H(2), CH(4)/N(2), and C(2)H(6)/CH(4) separation potentials of 572 COFs by combining grand canonical Monte Carlo (GCMC) and molecular dynamics (MD) simulations and density functional theory (DFT) calculations. …”
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    Combined GCMC, MD, and DFT Approach for Unlocking the Performances of COFs for Methane Purification
  17. 21837
    “…To which extend transcripts encoding only smORF peptides compare with canonical protein-coding genes, yet remain poorly understood. …”
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    Pri smORF Peptides Are Wide Mediators of Ecdysone Signaling, Contributing to Shape Spatiotemporal Responses
  18. 21838
    “…Imagestream analysis indicated a substantial portion of particles was positive for canonical EV markers (CD81, CD51), and Siglec‐F, a marker of alveolar macrophages. …”
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    Ozone‐induced changes in the murine lung extracellular vesicle small RNA landscape
  19. 21839
    “…Ingenuity Pathway Analysis (IPA) revealed that SARS-CoV-2 activated key canonical pathways and gene networks that intricately regulate general anti-viral as well as specific inflammatory pathways. …”
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    Drug repurposing for COVID-19 based on an integrative meta-analysis of SARS-CoV-2 induced gene signature in human airway epithelium
  20. 21840
    “…Overexpression of these isoforms is characteristic of tauopathies, which are currently untreatable neurodegenerative diseases. Though non-canonical functions of tau have drawn interest, the role of tau isoforms in these diseases has not been fully examined and may reveal new details of tau-driven pathology. …”
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    Transcriptome analyses reveal tau isoform-driven changes in transposable element and gene expression
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