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  1. 21881
    “…Telomeric repeats of Phytophthora follow a pattern of (TTTAGGG)(n) or (TTAGGGT)(n) rather than the canonical (TTAGGG)n. RxLR (arginine-any amino acid-leucine-arginine) motifs containing effectors diverge rapidly in Phytophthora and do not show any core common group. …”
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    Comparative Genome Analysis Across 128 Phytophthora Isolates Reveal Species-Specific Microsatellite Distribution and Localized Evolution of Compartmentalized Genomes
  2. 21882
    “…METHODS: The expressions of Notch1, Notch2, Notch3, Notch4, hes family bHLH transcription factor 1 (Hes1), and delta-like canonical Notch ligand 3 (DLL3) were detected by Western blot and the expressions of interleukin (IL)-10, IL-12, and IL1-β were detected using enzyme-linked immunosorbent assay after the co-culture of macrophages and stomach-cancer cells. …”
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    Elevated DLL3 in stomach cancer by tumor-associated macrophages enhances cancer-cell proliferation and cytokine secretion of macrophages
  3. 21883
    “…IHC was performed to assess islet hormones and both novel and canonical immune cell markers that were identified from unbiased, state-of-the-art workflows after reanalyzing murine scRNA-Seq data sets. …”
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    Evidence of islet CADM1-mediated immune cell interactions during human type 1 diabetes
  4. 21884
    “…In silico analysis of two genomic DNA segments (1870 bp 5′-flanking region and 1870 + 159 bp of first exon) revealed one X Core Promoter Element 1 (XCPE1), two SP1, and three potential non-canonical NBRE response elements (ncNBRE) but no CAAT or TATA box. …”
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    Transcriptional Regulation of the Synaptic Vesicle Protein Synaptogyrin-3 (SYNGR3) Gene: The Effects of NURR1 on Its Expression
  5. 21885
    “…CONCLUSION: The biomarkers and canonical pathways identified in this study may hold the key to understand the mechanisms of DbCM pathobiology and provide new targets for the therapeutic effect of SPM against DbCM by targeting lipid and amino acid metabolism pathways.…”
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    Transcriptomics Coupled to Proteomics Reveals Novel Targets for the Protective Role of Spermine in Diabetic Cardiomyopathy
  6. 21886
    “…Subsequently, a non-canonical amino acid was site-specifically incorporated using bio-orthogonal systems. …”
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    Cell-Free Systems Enable the Production of AB(5) Toxins for Diagnostic Applications
  7. 21887
    “…Data were also analyzed by canonical analysis of principal coordinates (CAP). …”
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    An Integrated Monitoring Approach to the Evaluation of the Environmental Impact of an Inshore Mariculture Plant (Mar Grande of Taranto, Ionian Sea)
  8. 21888
    “…Ampittia subvittatus (Hesperiidae) exhibits the gene order 2FFGO, characterised by two copies of trnF, one located in the canonical position and a second placed in the opposite strand between trnR and trnN. …”
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    Macrostructural Evolution of the Mitogenome of Butterflies (Lepidoptera, Papilionoidea)
  9. 21889
    “…In line with these findings, although hydroxyectoine reached 20 nmol mg(-1) of wet biomass in non-adapted cells, it was not detected in L. ferriphilum adapted to NaCl, suggesting that this canonical osmotic stress response was dispensable for salt adaptation. …”
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    Transcriptomic analysis of chloride tolerance in Leptospirillum ferriphilum DSM 14647 adapted to NaCl
  10. 21890
    por Yao, Y., Yu, Z., Ma, Y., Ou, Q., Wu, X., Lu, D., Li, X.
    Publicado 2022
    “…Notably, three ALK IGR patients who harbored no canonical oncogenic aberrations were confirmed with an EML4-ALK chimeric fusion product by RNA sequencing and/or ALK immunohistochemical assays. …”
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    Characterizing kinase intergenic-breakpoint rearrangements in a large-scale lung cancer population and real-world clinical outcomes
  11. 21891
    “…The HO(2) + SO(2) → HOSO + (3)O(2) reaction, both without a catalyst and with (H(2)O)(n) (n = 1–3) as a catalyst, has been investigated using CCSD(T)/CBS//M06-2X/aug-cc-pVTZ methods, and canonical variational transition state theory with small curvature tunneling (CVT/SCT). …”
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    Catalytic effect of (H(2)O)(n) (n = 1–3) clusters on the HO(2) + SO(2) → HOSO + (3)O(2) reaction under tropospheric conditions
  12. 21892
    “…They offer unique genomic strategies that could reestablish hormone expression in the context of canonical oncogenic mutations to reconstitute the GUCY2C axis and oppose transformation.…”
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    A β-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer
  13. 21893
    “…She had a homozygous mutation of the CD36 gene (c.1126-5_1127delTTTAGAT), which occurs in a canonical splice site (acceptor) and is predicted to disrupt or distort the normal gene product. …”
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    A Resuscitated Case of Acute Myocardial Infarction with both Familial Hypercholesterolemia Phenotype Caused by Possibly Oligogenic Variants of the PCSK9 and ABCG5 Genes and Type I CD36 Deficiency
  14. 21894
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    Genomic Profile in a Non-Seminoma Testicular Germ-Cell Tumor Cohort Reveals a Potential Biomarker of Sensitivity to Platinum-Based Therapy
  15. 21895
    “…Of them, five cases met the criteria of hypermutation (>10Mut/Mb), two of the five tumors had canonical mutations in the POLE proof‐reading domain, where a large proportion of mutations in these tumor genomes contributed to signature 10. …”
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    Rare cases of medulloblastoma with hypermutation
  16. 21896
    “…Egg weight and diameter were measured in 25 eggs per female using, respectively, ACIS AD- 600i scales with 0.01 g accuracy, and a microscope (Labo model L-711) using Canon Digital Camera Software 3 . Semen was collected using plastic syringes in 3 mL aliquots, then placed in an insulated ice-cooled container, and analyzed within two hours of collection. …”
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    Reproductive characteristics of the giant gurami sago strain ( Osphronemus goramy Lacepède, 1801): basic knowledge for a future hatchery development strategy
  17. 21897
    “…Conventional GLM analysis, using a canonical haemodynamic response (HR) function, showed disappearance of iSM1 NBR in subjects over 50 years of age. …”
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    Across the adult lifespan the ipsilateral sensorimotor cortex negative BOLD response exhibits decreases in magnitude and spatial extent suggesting declining inhibitory control
  18. 21898
    “…Multi-omics data integration and Canonical correspondence analysis (CCA) showed that both the ileum selenium content and the laying rate were highly correlated with pathways and bacteria enriched in metabolism and immune response. …”
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    Microbiome and ileum transcriptome revealed the boosting effects of selenium yeast on egg production in aged laying hens
  19. 21899
    “…Relationships of gut microbiota with lifestyle activity, body composition, and metabolic profiles were assessed by canonical correlation analysis (CCA) and Spearman correlation. …”
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    Association of Human Intestinal Microbiota with Lifestyle Activity, Adiposity, and Metabolic Profiles in Thai Children with Obesity
  20. 21900
    “…Using functional magnetic resonance images acquired both acutely and chronically after injury (∼1 week and ∼6 months post-injury, respectively), we map post-traumatic FC changes across 136 participants aged 19–79 (52 females), both within and between the brain’s seven canonical FC networks: default mode, dorsal attention, frontoparietal, limbic, somatomotor, ventral attention, and visual. …”
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    Functional Connectome Dynamics After Mild Traumatic Brain Injury According to Age and Sex
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