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  1. 21901
    “…A significant proportion of these tumors is characterized by aberrant activation of the canonical sonic hedgehog (SHH) signaling pathway. Although small-molecule inhibitors targeting Smoothened (SMO) have proven a promising treatment approach for SHH-MB subgroup, primary or acquired resistance impedes its clinical efficacy. …”
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    MEDB-45. Functional genomics identifies epigenetic regulators as novel therapeutic targets for sonic hedgehog medulloblastoma
  2. 21902
    “…The relative abundance of the top ten fungi at each classification level differed greatly in different stages. Canonical correspondence analysis (CCA) and Spearman’s correlation analysis showed that conductivity (EC) was the main soil factor affecting the composition of Populus euphratica rhizosphere soil fungal community (P < 0.01), followed by total dissolvable salts (TDS) and available potassium (AK) (P < 0.05). …”
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    High-throughput sequencing reveals rhizosphere fungal community composition and diversity at different growth stages of Populus euphratica in the lower reaches of the Tarim River
  3. 21903
    “…Mechanistically, exosomal EPHA2 activates the AMPK signaling via the ligand Ephrin A1-dependent canonical forward signaling pathway. Moreover, inhibition of the AMPK signaling impairs exosomal EPHA2-mediated pro-angiogenic effects. …”
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    Exosomal EPHA2 derived from highly metastatic breast cancer cells promotes angiogenesis by activating the AMPK signaling pathway through Ephrin A1-EPHA2 forward signaling
  4. 21904
    “…Transient receptor potential canonical 4 (TRPC4) is a receptor-operated cation channel codependent on both the G(q/11)–phospholipase C signaling pathway and G(i/o) proteins for activation. …”
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    TRPC4 and GIRK channels underlie neuronal coding of firing patterns that reflect G(q/11)–G(i/o) coincidence signals of variable strengths
  5. 21905
    “…Interestingly, in contrast to canonical TGF‐β signaling through Smad2/3, Hp‐TGM stimulation was slower and more sustained. …”
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    The parasite cytokine mimic Hp‐TGM potently replicates the regulatory effects of TGF‐β on murine CD4(+) T cells
  6. 21906
    “…The effects of CDNF on 6-OHDA-induced alternation of the canonical pathway in BV2 microglial cells is highly associated with PI3K-mediated phagosome formation. …”
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    Modulating Microglia/Macrophage Activation by CDNF Promotes Transplantation of Fetal Ventral Mesencephalic Graft Survival and Function in a Hemiparkinsonian Rat Model
  7. 21907
    “…Variations in the effects of driving forces on ESs were examined at three scales: provincial, ecoregional, and subecoregional scales. Finally, canonical correlation analysis was used to identify the major environmental factors associated with these variations in each ecoregion. …”
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    Integrating the effects of driving forces on ecosystem services into ecological management: A case study from Sichuan Province, China
  8. 21908
    “…Atrial natriuretic peptide (ANP), a canonical cardiac hormone, is mainly secreted from atrial myocytes and is involved in the regulation of body fluid, blood pressure homeostasis, and antioxidants. …”
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    Cholecystokinin Octapeptide Promotes ANP Secretion through Activation of NOX4–PGC-1α–PPARα/PPARγ Signaling in Isolated Beating Rat Atria
  9. 21909
    “…Differential expressed genes in the CXCR4-upregulation group were enriched in canonical pathways associated with oncogenesis. DLBCL with CXCR4 upregulation had lower degree of CD8(+) T cell infiltration. …”
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    Identification of CXCR4 Upregulation in Diffuse Large B-Cell Lymphoma Associated with Prognostic Significance and Clinicopathological Characteristics
  10. 21910
    “…This variant, called TDP43C-spl, is generated through use of non-canonical splice sites in exon 6, skipping 1,020 bp and encoding a 272 aa protein lacking the C-terminus with the first 256 aa identical to full-length TDP-43 and the same 18 amino acid C-terminal unique sequence. …”
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    A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS
  11. 21911
    “…Nucleoside 1 forms a stable base pair with dA which is as stable as the canonical dA–dT pair. The bidentate 1–dA base pair is strengthened by a third hydrogen bond provided by the dA analogue 3-bromo­pyrazolo­[3,4-d]pyrimidine-4,6-di­amine 2′-de­oxy­ribo­furan­oside (4). …”
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    The 2′-de­oxy­ribo­furan­oside of 3-phenyl­tetra­hydropyrimido[4,5-c]pyridazin-7-one: a bicyclic nucleoside with sugar residues in N and S con­formations, and its mol­ecular recognition
  12. 21912
    “…This review covers articles published within the years 2000–2021, with a strong focus on the recent years (2016–2021). However, some canonical papers published in twentieth century are also mentioned.…”
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    The New Face of a Well-Known Antibiotic: A Review of the Anticancer Activity of Enoxacin and Its Derivatives
  13. 21913
    “…Other AAV structures start near the 5-fold axis, but now β-strand A is the minor conformer and, for the major conformer, partially ordered N termini near the 2-fold axis join the canonical capsid jellyroll fold at the βA-βB turn. …”
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    Adeno-Associated Virus Receptor-Binding: Flexible Domains and Alternative Conformations through Cryo-Electron Tomography of Adeno-Associated Virus 2 (AAV2) and AAV5 Complexes
  14. 21914
    “…Comprehensive immunophenotypic and transcriptomic analysis at day 0 enabled a refined characterization of T‐cell maturational states and the identification of a donor‐specific subset of terminally differentiated T‐cells that would have been otherwise overlooked using canonical cell classification schema. As expected, activation downregulated naïve‐cell markers and upregulated effector molecules, proliferation regulators, co‐inhibitory and co‐stimulatory receptors. …”
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    Single cell multiomic analysis of T cell exhaustion in vitro
  15. 21915
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    Proteasome inhibition alters mitotic progression through the upregulation of centromeric α‐Satellite RNAs
  16. 21916
    “…In the presence of BI-749327 (a selective canonical TRP 6 channel inhibitor, 1 μM, 48 h), Klotho (100 pM, 48 h) could not inhibit fibroblast migration nor suppress the TRP currents. …”
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    Klotho Modulates Pro-Fibrotic Activities in Human Atrial Fibroblasts through Inhibition of Phospholipase C Signaling and Suppression of Store-Operated Calcium Entry
  17. 21917
    “…We found that cholesterol activated canonical Hedgehog (Hh) signaling by increasing cilium Gli activity in PCa cells, while palmitate activated Hh independent of Gli. …”
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    Fatty Acid Signaling Impacts Prostate Cancer Lineage Plasticity in an Autocrine and Paracrine Manner
  18. 21918
    “…P2RX7 plays a role in many biological processes, including production of proinflammatory cytokines such as interleukin (IL)‐1β via the canonical inflammasome pathway. P2RX7 has been shown to be important in inflammation and fibrosis and may also play a role in autoimmunity. …”
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    Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways
  19. 21919
    “…PRIMARY AND SECONDARY OUTCOME MEASURES: For the frequency ranking of clinical codes, canonical correlation analysis was applied to correlations of clinical code usage of 1, 3 and 5 years. …”
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    Clinical code usage in UK general practice: a cohort study exploring 18 conditions over 14 years
  20. 21920
    “…The tachykinin neuropeptide substance P (SP) is the canonical agonist peptide for the neurokinin 1 receptor (NK(1)R). …”
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    The effect of substance P and its common in vivo‐formed metabolites on MRGPRX2 and human mast cell activation
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