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  1. 22081
    “…Further, the RELA(FUS) target genes were found to be overlapped with Rela target genes primarily via non-canonical NF-κB binding sites. Using a series of truncation and substitution mutants of RELA(FUS), we also show that the activation domain in the RELA(FUS) moiety is necessary for the regulation of gene expression of these RELA(FUS) target genes. …”
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    C11orf95-RELA fusion drives aberrant gene expression through the unique epigenetic regulation for ependymoma formation
  2. 22082
    por Reuper, Hendrik, Krenz, Björn
    Publicado 2021
    “…This indicates a specific interaction between P1-DEU 2 and the AtG3BP family which is not solely based on the canonical interaction motifs. SUPPLEMENTARY INFORMATION: The online version of this article (10.1007/s11262-021-01829-w) contains supplementary material, which is available to authorized users.…”
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    Comparison of two Turnip mosaic virus P1 proteins in their ability to co-localize with the Arabidopsis thaliana G3BP-2 protein
  3. 22083
    “…The molecular regulation of diseases and functions and canonical pathways revealed that ABPPk had more participation and advantages in the vasculature and immune system areas, especially angiogenesis regulation. …”
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    Protective effects and molecular mechanisms of Achyranthes bidentata polypeptide k on Schwann cells
  4. 22084
    “…High-gamma power increases with increased task difficulty were more likely in areas that are within the canonical frontoparietal network template. CONCLUSIONS: These results are the first step toward developing electrocorticography as a tool for mapping of executive function complementarily to direct electrical stimulation to guide resection. …”
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    Intraoperative mapping of executive function using electrocorticography for patients with low-grade gliomas
  5. 22085
    “…And the microbial community composition was also significantly different between the lake and its connected river habitats. Canonical correspondence analysis demonstrated that salinity and total suspended solids were the most important environmental factors shaping the community variations. …”
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    Contrast diversity patterns and processes of microbial community assembly in a river-lake continuum across a catchment scale in northwestern China
  6. 22086
    “…In SG epithelial cells, IL‐17 inhibited acetylcholine‐induced calcium movement and downregulated the expression of transient receptor potential canonical 1 via promoting Nfkbiz mRNA stabilisation. …”
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    IL‐17 drives salivary gland dysfunction via inhibiting TRPC1‐mediated calcium movement in Sjögren’s syndrome
  7. 22087
    “…Conditional knock-out of Sox9 from the vasculature (Sox9(fl/fl)/Cdh5-Cre(ER) RosaYFP) depletes EVP while enhancing Rbpj expression and canonical Notch signalling. Additionally, skin wound analysis from Sox9 conditional knock-out mice demonstrates a significant reduction in pathological EndMT resulting in reduced scar area. …”
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    Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors
  8. 22088
    “…CONCLUSIONS: Through integrated multiomics profiling and unbiased canonical pathway analyses, our results unveil heterogeneities in the transcriptional, phenotypic, functional, and metabolic profiles of donor and patient CAR T cells, providing mechanistic basis for ameliorating clinical outcomes and developing next-generation ‘off- the-shelf’ allogeneic products.…”
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    Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells
  9. 22089
    “…Their fates are collectively determined by an orchestra of pathways in response to physiological and external cues. The canonical Wnt pathway signals MPCs to commit to osteogenic differentiation at the expense of adipogenic fate. …”
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    Wnt/ß-catenin-mediated p53 suppression is indispensable for osteogenesis of mesenchymal progenitor cells
  10. 22090
    “…We show that blockade of JNK1/2 signalling using small molecule inhibitors, or knockdown of the canonical JNK substrate c-Jun, reduces cell proliferation and induces apoptosis in cervical cancer cells. …”
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    E6-mediated activation of JNK drives EGFR signalling to promote proliferation and viral oncoprotein expression in cervical cancer
  11. 22091
    “…This mutation affects the canonical stop codon of PIK3CA (NM_006218.4) and is predicted to produce a prolonged protein with four additional residues. qRT-PCR demonstrated that the mRNA expression levels of the patient’s affected skin tissue were comparable compared to the normal control. …”
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    Somatic frameshift mutation in PIK3CA causes CLOVES syndrome by provoking PI3K/AKT/mTOR pathway
  12. 22092
    “…RESULTS: During the early phases of inflorescence development, multiple key canonical floral integrators and pathways were identified. …”
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    Reproductive developmental transcriptome analysis of Tripidium ravennae (Poaceae)
  13. 22093
    “…Using data from two large-scale transcriptome studies, we established a workflow for the de novo identification and quantification of alternative splice and editing events. We detected all canonical iGluR splice junctions, assessed the abundance of alternative events described in the literature, and identified new splice events in AMPA, kainate, delta, and NMDA receptor subunits. …”
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    Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data
  14. 22094
    “…PCR array showed that the effect of melatonin on chondrocyte hypertrophic differentiation was accompanied by the up-regulation of multiple target genes of the canonical Wnt signaling pathway, and this effect was blocked by XAV-939. …”
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    Melatonin contributes to the hypertrophic differentiation of mesenchymal stem cell-derived chondrocytes via activation of the Wnt/β-catenin signaling pathway: Melatonin promotes MSC-derived chondrocytes hypertrophy
  15. 22095
    “…The main function of the SRCAP complex is to promote the exchange of histone H2A with the H2A.Z variant. According to the canonical role played by the SRCAP protein in epigenetic regulation, the Floating-Harbor syndrome is thought to be a consequence of chromatin perturbations. …”
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    The ATPase SRCAP is associated with the mitotic apparatus, uncovering novel molecular aspects of Floating-Harbor syndrome
  16. 22096
    “…Additionally, no β-catenin nuclear localization was observed in LGR5-positive BC, indicating that canonical Wnt pathway activation is less likely involved in LGR5 expression in BC. …”
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    Expression of LGR5 in mammary myoepithelial cells and in triple-negative breast cancers
  17. 22097
    “…We performed system biology analysis (SBA) on their target genes to identify main functions and canonical pathways. A functional in vitro assay was carried out incubating endothelial cells (ECs) in anaphylactic conditions. …”
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    Increased miR‐21‐3p and miR‐487b‐3p serum levels during anaphylactic reaction in food allergic children
  18. 22098
    “…Frizzled-7 is a key protein expressed on the surface of endothelial cells that controls vascular permeability through the Wnt-canonical pathway involving WNT1-inducible signaling pathway protein 1 (WISPI). …”
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    Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice
  19. 22099
    “…RNAi-mediated knockdown and overexpression experiments using genetically encoded fluorescent reporters and defined mutant constructs in cell lines, primary neurons, and brains show that SSH1, the canonical CFL (cofilin) phosphatase, mediates the dephosphorylation of phospho-Ser403-SQSTM1, thereby impairing SQSTM1 flux and phospho-MAPT/tau clearance. …”
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    SSH1 impedes SQSTM1/p62 flux and MAPT/Tau clearance independent of CFL (cofilin) activation
  20. 22100
    “…IPA showed the networks, biological functions, and canonical pathways influencing the activity of triptolide towards tumor cells. …”
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    Network pharmacology of triptolide in cancer cells: implications for transcription factor binding
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