Materias dentro de su búsqueda.
Mostrando 22,201 - 22,220 Resultados de 23,561 Para Buscar '"canonization"', tiempo de consulta: 0.36s Limitar resultados
  1. 22201
    “…By using pharmacological inhibitors as well as CRISPR/Cas9 deleted macrophages, we identify SARS-CoV-2 to engage canonical TLR4-MyD88 signalling. Importantly, we demonstrate that TLR4 blockage prevents exaggerated inflammatory responses in human macrophages infected with different SARS-CoV-2 variants, including immune escape variants B.1.1.7.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Online Artículo Texto
    SARS-CoV-2 activates the TLR4/MyD88 pathway in human macrophages: A possible correlation with strong pro-inflammatory responses in severe COVID-19
  2. 22202
    “…RESULTS: The structure of SA1388 has been solved to 2.0Å resolution by single wavelength anomalous dispersion phasing method using selenium anomalous signals. It reveals a canonical NIF3-like fold containing two domains with a PII-like domain inserted in the middle of the polypeptide. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Structure of a conserved hypothetical protein SA1388 from S. aureus reveals a capped hexameric toroid with two PII domain lids and a dinuclear metal center
  3. 22203
    “…BACKGROUND: β-catenin is an essential mediator of canonical Wnt signaling and a central component of the cadherin-catenin epithelial adhesion complex. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Wnt/β-catenin signaling is required for development of the exocrine pancreas
  4. 22204
    “…BACKGROUND: Three dimensional biomedical image sets are becoming ubiquitous, along with the canonical atlases providing the necessary spatial context for analysis. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    NeuroTerrain – a client-server system for browsing 3D biomedical image data sets
  5. 22205
    por Merkl, Rainer
    Publicado 2007
    “…Enzymes catalysing the last seven steps of tryptophan biosynthesis are encoded in the canonical trp operon. Among the trp genes are most frequently trpA and trpB, which code for the alpha and beta subunit of tryptophan synthase. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Modelling the evolution of the archeal tryptophan synthase
  6. 22206
    “…Arylhydrocarbon receptor is structurally related to Bmal1, a canonical clock gene.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    A QTL on mouse chromosome 12 for the genetic variance in free-running circadian period between inbred strains of mice
  7. 22207
    “…Functional sites are predicted using six different methods (phylogenetic motifs, two methods that identify subfamily-specific positions, and three different conservation scores). A canonical set of 34 functional sites identified by Yamashita et al. within the recently solved LeuT(Aa )structure is used to assess the quality of the predictions, most of which are predicted by the bioinformatic methods. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Assessing the ability of sequence-based methods to provide functional insight within membrane integral proteins: a case study analyzing the neurotransmitter/Na(+ )symporter family
  8. 22208
    “…Our data indicate that the DAF-2 regulated transcription factor DAF-16/FOXO positively modulates hif-1 transcription under anoxia but opposes expression of the HIF-1 responsive globin genes itself. In contrast, the canonical globin of C. elegans, ZK637.13, is not responsive to anoxia. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Wide diversity in structure and expression profiles among members of the Caenorhabditis elegans globin protein family
  9. 22209
    “…Its C-terminal domain, which is common to the four EED isoforms, contains seven repeats of a canonical WD-40 motif. EED is an interactor of three HIV-1 proteins, matrix (MA), integrase (IN) and Nef. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed β-propeller domain of the HIV-1 cellular interactor EED
  10. 22210
    “…A number of transcripts containing canonical Sm binding element sequences (Sm Y RNAs) also showed reduced expression after depletion of protein components of C/D box snoRNPs, whereas the expression of some stem-bulge RNAs (sbRNAs) was increased after depletion of the same proteins. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Microarray analysis of ncRNA expression patterns in Caenorhabditis elegans after RNAi against snoRNA associated proteins
  11. 22211
    por Xu, Wanhong, Coombs, Kevin M
    Publicado 2008
    “…This implies significant evolutionary constraints are placed on dsRNA RdRp molecules, particularly in regions comprising the canonical polymerase motifs and residues thought to interact directly with template and nascent mRNA. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Avian reovirus L2 genome segment sequences and predicted structure/function of the encoded RNA-dependent RNA polymerase protein
  12. 22212
    por Zhang, Ming, Swanson, Patrick C
    Publicado 2009
    “…Whether HMGB1/2 can promote RAG-mediated DNA cleavage at sites lacking a canonical RSS by targeting or stabilizing structural distortions is unclear, but is important for understanding the etiology of chromosomal translocations involving antigen receptor genes and proto-oncogene sequences that do not contain an obvious RSS-like element. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex
  13. 22213
    “…An equally important question is how B cells interact with, and respond to, the gp41 MPER epitope, including whether they engage this epitope in a non-canonical manner i.e., by non-paratopic recognition via B cell receptors (BCR). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Functional, Non-Clonal IgM(a)-Restricted B Cell Receptor Interactions with the HIV-1 Envelope gp41 Membrane Proximal External Region
  14. 22214
    “…Gene expression profiling using Illumina™ microarrays and Ingenuity pathways analysis showed that 129 genes involved in canonical pathways such as Ubiquitination or Neurotransmission were co-regulated in Prnp −/− and Tg20 mice. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Regulation of GABA(A) and Glutamate Receptor Expression, Synaptic Facilitation and Long-Term Potentiation in the Hippocampus of Prion Mutant Mice
  15. 22215
    por Zhou, Hong, Fu, Guodong, Yu, Hui, Peng, Chun
    Publicado 2009
    “…The transcriptional regulation of aromatase gene by TGF-beta1 is mediated by the canonical TGF-beta pathway involving TbetaRII, ALK5 and Smad2. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Transforming growth factor-beta inhibits aromatase gene transcription in human trophoblast cells via the Smad2 signaling pathway
  16. 22216
    “…The 3D X-ray structure of SpGH38, obtained in native form at 1.9 Å resolution and in complex with the inhibitor swainsonine (K (i) 18 µM) at 2.6 Å, reveals a canonical GH38 five-domain structure in which the catalytic “–1” subsite shows high similarity with the Drosophila enzyme, including the catalytic Zn(2+) ion. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Structure and Kinetic Investigation of Streptococcus pyogenes Family GH38 α-Mannosidase
  17. 22217
    “…BACKGROUND: Vertebrate heterochromatin contains a non-allelic variant of the histone H2A called macroH2A1, which has the characteristic of being three times the size of the canonical H2A. The macroH2A1 C-terminal extension can recruit onto chromatin the poly-ADP-ribose polymerase (PARP)1, which is crucial for DNA repair. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Histone variant macroH2A1 deletion in mice causes female-specific steatosis
  18. 22218
    “…BACKGROUND: Gprc5b, a retinoic acid-inducible orphan G protein–coupled receptor (GPCR), is a member of the group C metabotropic glutamate receptor family proteins possibly involved in non-canonical Wnt signaling. Many GPCR transcripts are alternatively spliced, which diversifies this class of proteins in their cell- and tissue-specific signaling, regulatory and/or pharmacological properties. …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    A Flanking Gene Problem Leads to the Discovery of a Gprc5b Splice Variant Predominantly Expressed in C57Bl/6J Mouse Brain and in Maturing Neurons
  19. 22219
    “…Further analyses revealed the presence in this short sequence of several conserved, putative transcription factor binding sites: LEF/TCF (Lymphoid Enhancer Factor/T-Cell Factor) which are effectors of the canonical Wnt pathway; HNF6/OC2 (Hepatocyte Nuclear Factor-6/Oncecut-2) members of the ONECUT family and NF-Y/CAAT (Nuclear Factor-Y). …”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    A short upstream promoter region mediates transcriptional regulation of the mouse doublecortin gene in differentiating neurons
  20. 22220
    “…In contrast, for ZHX2 HD2 the observed altered conformation involving rearrangement of helix I, relative to the canonical homeodomain fold, disrupts the normal DNA binding site, although protein-protein binding is possible as observed in homodimer formation.…”
    Enlace del recurso
    Enlace del recurso
    Enlace del recurso
    Texto
    Novel structural features in two ZHX homeodomains derived from a systematic study of single and multiple domains
Herramientas de búsqueda: RSS