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  1. 22701
    “…Moreover, this high-efficiency editing occurs even at the non-canonical TTV PAM sites. CONCLUSIONS: Our results demonstrate that LbCas12a-RVQ is a powerful tool for genome editing in human cells while LbCas12a-RRV confers robust genome editing in plants. …”
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    Boosting genome editing efficiency in human cells and plants with novel LbCas12a variants
  2. 22702
    “…METHODS: We used CRISPR/Cas9 homology-directed repair to stably integrate MetRS(L274G) into cells, enabling the incorporation of the non-canonical amino acid, azidonorleucine (ANL), and facilitating selective protein isolation using click chemistry. …”
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    A Mutant Methionyl-tRNA Synthetase-Based toolkit to assess induced-Mesenchymal Stromal Cell secretome in mixed-culture disease models
  3. 22703
    “…IPA identified five upstream regulators that targeted proteins associated with progression, as well as a canonical pathway with a higher signal in the progression group. …”
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    Protein biomarkers of disease progression in patients with systemic sclerosis associated interstitial lung disease
  4. 22704
    “…More than that, the fact that hucMSC-exo activated the canonical Wnt signaling pathway to promote mucosal healing was uncovered by not only RNA-sequencing but also relevant experimental data. …”
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    HucMSC-Exo Promote Mucosal Healing in Experimental Colitis by Accelerating Intestinal Stem Cells and Epithelium Regeneration via Wnt Signaling Pathway
  5. 22705
    “…Here, we utilized mass spectrometry and RNA-sequencing to report a non-canonical role for OTX2 in regulating alternative splicing. …”
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    MDB-21. THE OTX2-REGULATED ALTERNATIVE SPLICING LANDSCAPE CONTROLS DIFFERENTIATION AND RECONSTITUTES THE DEVELOPMENTAL ORIGINS OF GROUP 3 MEDULLOBLASTOMA
  6. 22706
    “…Pharmacodynamics demonstrated concentration-dependent downregulation of miR-221 and upregulation of its CDKN1B/p27 and PTEN canonical targets. Five mg/kg was defined as the recommended phase II dose. …”
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    Safety and activity of the first-in-class locked nucleic acid (LNA) miR-221 selective inhibitor in refractory advanced cancer patients: a first-in-human, phase 1, open-label, dose-escalation study
  7. 22707
    “…The sABE system efficiently generated A-G mutations at disease-relevant loci (T1214C in GAA and A494G in MFN2) in HEK293T cells and several canonical Pcsk9 splice sites in N2a cells. Moreover, the sABE enabled in vivo delivery in a single adeno-associated virus (AAV) vector with slight efficiency. …”
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    A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9
  8. 22708
    “…IDH mutations were stratified into IDH1-R132H and non-canonical mutations. Background and survival data were obtained. …”
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    Correlating MRI features with additional genetic markers and patient survival in histological grade 2-3 IDH-mutant astrocytomas
  9. 22709
    por Weiss, Emmanuel, de la Peña-Ramirez, Carlos, Aguilar, Ferran, Lozano, Juan-Jose, Sánchez-Garrido, Cristina, Sierra, Patricia, Martin, Pedro Izquierdo-Bueno, Diaz, Juan Manuel, Fenaille, François, Castelli, Florence A, Gustot, Thierry, Laleman, Wim, Albillos, Agustín, Alessandria, Carlo, Domenicali, Marco, Caraceni, Paolo, Piano, Salvatore, Saliba, Faouzi, Zeuzem, Stefan, Gerbes, Alexander L, Wendon, Julia A, Jansen, Christian, Gu, Wenyi, Papp, Maria, Mookerjee, Raj, Gambino, Carmine Gabriele, Jiménez, Cesar, Giovo, Ilaria, Zaccherini, Giacomo, Merli, Manuela, Putignano, Antonella, Uschner, Frank Erhard, Berg, Thomas, Bruns, Tony, Trautwein, Christian, Zipprich, Alexander, Bañares, Rafael, Presa, José, Genesca, Joan, Vargas, Victor, Fernández, Javier, Bernardi, Mauro, Angeli, Paolo, Jalan, Rajiv, Claria, Joan, Junot, Christophe, Moreau, Richard, Trebicka, Jonel, Arroyo, Vicente
    Publicado 2023
    “…METHODS: Two prospective multicentre large cohorts from Europe for investigating ACLF and development of ACLF, CANONIC (discovery, n=831) and PREDICT (validation, n=851), were explored by untargeted serum metabolomics to identify and validate metabolites which could allow improved prognostic modelling. …”
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    Sympathetic nervous activation, mitochondrial dysfunction and outcome in acutely decompensated cirrhosis: the metabolomic prognostic models (CLIF-C MET)
  10. 22710
    “…OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is characterised by an abundant desmoplastic stroma composed of cancer-associated fibroblasts (CAF) and interspersed immune cells. A non-canonical CD8(+) T-cell subpopulation producing IL-17A (Tc17) promotes autoimmunity and has been identified in tumours. …”
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    IL-17A-producing CD8(+) T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts
  11. 22711
    “…At the same time, the canonical inflammasome path is activated by the organic components of PM, including LPS (Lipopolysaccharide/endotoxin). …”
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    Air pollution induces pyroptosis of human monocytes through activation of inflammasomes and Caspase-3-dependent pathways
  12. 22712
    por Dagne, Yitayih, Birhanu, Liyew
    Publicado 2023
    “…The plant community types and vegetation-environment relationships were analyzed using hierarchical cluster analysis and Canonical correspondence analysis (CCA) in R software, respectively. …”
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    Floristic composition and plant community distribution along environmental gradients in Guard dry Afromontane forest of Northwestern Ethiopia
  13. 22713
    “…RESULTS: Among the 125 patients, a single canonical echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion was detected in 65.6% (82/125), a single non-EML4-ALK fusion was detected in 13.6% (17/125), and multiple ALK fusions were detected in 20.8% (26/125). …”
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    Superior clinical outcomes in patients with non-small cell lung cancer harboring multiple ALK fusions treated with tyrosine kinase inhibitors
  14. 22714
    “…This study will generate a body of knowledge that is fundamental to drive optimization of BCI application in SCI as a top-down therapeutic intervention, thus beyond the canonical use of BCI as assistive tool. TRIAL REGISTRATION: Name of registry: DiSCIoser: improving arm sensorimotor functions after spinal cord injury via brain-computer interface training (DiSCIoser). …”
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    DiSCIoser: unlocking recovery potential of arm sensorimotor functions after spinal cord injury by promoting activity-dependent brain plasticity by means of brain-computer interface technology: a randomized controlled trial to test efficacy
  15. 22715
    “…We previously reported that myeloid SIRT1 regulates the inflamed liver’s canonical pyroptosis cell death pathway. However, whether/how hepatocyte SIRT1 is engaged in programmed cell death in the cold-stressed liver remains uncertain. …”
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    SIRT1 regulates hepatocyte programmed cell death via GSDME - IL18 axis in human and mouse liver transplantation
  16. 22716
    “…IPA analysis identified those canonical pathways differentially expressed (P < 0.05) between comparison groups. …”
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    Host adaptive immunity deficiency in severe pandemic influenza
  17. 22717
    “…Utilising both pharmacological inhibitors, including a new TAK1 inhibitor, NG25, and genetic models, we provide evidence that both the canonical (IKKα and IKKβ) and IKK-related (IKKε and TBK1) kinases mediate TLR agonist induced phosphorylation of LRRK2 in vivo. …”
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    The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling
  18. 22718
    “…Despite being a canonical presenting feature of mitochondrial disease, the genetic basis of progressive external ophthalmoplegia remains unknown in a large proportion of patients. …”
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    Mutations in the SPG7 gene cause chronic progressive external ophthalmoplegia through disordered mitochondrial DNA maintenance
  19. 22719
    “…RESULTS: We found an internal domain in the N-terminal extension, called Nβ, that is essential for NaTrxh secretion but is not hydrophobic, a canonical feature of a signal peptide. The lack of hydrophobicity as well as the location of the secretion signal within the NaTrxh primary structure, suggest an unorthodox secretion route for NaTrxh. …”
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    A novel motif in the NaTrxh N-terminus promotes its secretion, whereas the C-terminus participates in its interaction with S-RNase in vitro
  20. 22720
    “…A substrate preference for dCTP and its methylated or halogen-modified derivatives over the other canonical (deoxy-) NTPs was demonstrated from enzymatic assay. …”
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    Human dCTP pyrophosphatase 1 promotes breast cancer cell growth and stemness through the modulation on 5-methyl-dCTP metabolism and global hypomethylation
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