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23021“…In addition, reverse transcription quantitative polymerase chain reaction results stating that hsa_circ_0087862 and hsa_circ_0012077 were validated in an independent cohort of subjects. Canonical correlation analysis results indicated a potential connection between exosomal hsa_circ_0012077 expression level and immunoglobulin G levels in CSF. …”
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23022“…The transcription factor 7-like 2 (TCF7L2) gene product TCF4 is a transcription factor that acts as a downstream effector in the canonical Wnt signaling pathway and may be important in the development of both type 2 diabetes and renal development and disease. …”
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23023por Segato, Severino, Caligiani, Augusta, Contiero, Barbara, Galaverna, Gianni, Bisutti, Vittoria, Cozzi, Giulio“…Samples (n = 55) were submitted to chemical analysis and to (1)H NMR coupled with multivariate canonical discriminant analysis. Choline, 2,3-butanediol, lysine, tyrosine, and some signals of sugar-like compounds were suggested as the main water-soluble metabolites useful to discriminate cheese according to cows’ feeding system. …”
Publicado 2019
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23024por Houston, James, Allendorfer, Jane, Nenert, Rodolph, Goodman, Adam M., Szaflarski, Jerzy P.“…Results focused primarily on significant relationships (p < 0.05, cluster-wise FDR corrected for multiple comparisons) in the canonical language white matter pathways. We found a diffuse linear decrease with age in global white matter FA and a significant focal increase in FA with age within the bilateral superior cerebellar peduncles (SCPs). …”
Publicado 2019
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23025por Grob, Dagmar, Oostveen, Luuk, Rühaak, Jan, Heldmann, Stefan, Mohr, Brian, Michielsen, Koen, Dorn, Sabrina, Prokop, Mathias, Kachelrieβ, Marc, Brink, Monique, Sechopoulos, Ioannis“…Registration was performed using three lung registration algorithms — a commercial (algorithm A) and a prototype (algorithm B) version from Canon Medical Systems and an algorithm from the MEVIS Fraunhofer institute (algorithm C). …”
Publicado 2019
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23026por Ogata, Hidenori, Zhang, Xu, Yamasaki, Ryo, Fujii, Takayuki, Machida, Akira, Morimoto, Nobutoshi, Kaida, Kenichi, Masuda, Teruaki, Ando, Yukio, Kuwahara, Motoi, Kusunoki, Susumu, Nakamura, Yuri, Matsushita, Takuya, Isobe, Noriko, Kira, Jun‐ichi“…By contrast, NF155(−) CIDP had significantly increased IFN‐γ compared with NIND, and exhibited positive correlations of IFN‐γ, CXCL10/IP‐10, and CXCL8/IL‐8 with CSF protein. Canonical discriminant analysis of cytokines/chemokines revealed that NF155(+) and NF155(−) CIDP were separable, and that IL‐4, IL‐10, and IL‐13 were the three most significant discriminators. …”
Publicado 2019
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23027“…Finally, we demonstrated that Withaferin A significantly downregulates cytosolic and nuclear levels of phospho-p65, the active canonical NF-κB transcription factor, in xenografted tumors. …”
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23028por Edlow, Andrea G., Guedj, Faycal, Sverdlov, Deanna, Pennings, Jeroen L. A., Bianchi, Diana W.“…Functional analyses identified significant upregulation of canonical pathways and upstream regulators involved in cell cycle regulation, synaptic plasticity, and sensory nervous system development in the fetal brain, and significant downregulation of pathways related to cell and embryo death. …”
Publicado 2019
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23029por Banach-Orłowska, Magdalena, Wyszyńska, Renata, Pyrzyńska, Beata, Maksymowicz, Małgorzata, Gołąb, Jakub, Miączyńska, Marta“…RESULTS: We showed that filipin-mediated sequestration of cholesterol or its depletion from the plasma membrane with methyl-β-cyclodextrin impaired LTβR internalization and potentiated LTβR-dependent activation of the canonical branch of the NF-κB pathway. The latter was manifested by enhanced degradation of IκBα inhibitor, elevated RelA phosphorylation, substantial increase in the expression of NF-κB target genes encoding, among others, cytokines and adhesion molecules known to play important roles in immune response. …”
Publicado 2019
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23030por Jagielski, Tomasz, Borówka, Paulina, Bakuła, Zofia, Lach, Jakub, Marciniak, Błażej, Brzostek, Anna, Dziadek, Jarosław, Dziurzyński, Mikołaj, Pennings, Lian, van Ingen, Jakko, Žolnir-Dovč, Manca, Strapagiel, Dominik“…The present work extends the recently published findings by using a three-pronged computational strategy, based on the alignment fraction-average nucleotide identity, genome-to-genome distance, and core-genome phylogeny, yet essentially independent and much larger sample, and thus delivers a more refined and complete picture of the M. kansasii complex. Furthermore, five canonical taxonomic markers were used, i.e., 16S rRNA, hsp65, rpoB, and tuf genes, as well as the 16S-23S rRNA intergenic spacer region (ITS). …”
Publicado 2020
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23031por Nima, Ali Al, Cloninger, Kevin M., Persson, Björn N., Sikström, Sverker, Garcia, Danilo“…It is considered as one of the best available proxies for a broader, more canonical form of well-being. For over 30 years, one important distinction in the conceptualization of subjective well-being is the contrast between more affective evaluations of biological emotional reactions and more cognitive evaluations of one’s life in relation to a psychologically self-imposed ideal. …”
Publicado 2020
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23032por Wingo, Thomas S., Yang, Jingjing, Fan, Wen, Min Canon, Se, Gerasimov, Ekaterina Sergeevna, Lori, Adriana, Logsdon, Benjamin, Yao, Bing, Seyfried, Nicholas T., Lah, James J., Levey, Allan I., Boyle, Patricia A., Schneider, Julia A., De Jager, Philip L., Bennett, David A., Wingo, Aliza P.Enlace del recurso
Publicado 2020
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23033por Janssen, Axel B., Bartholomew, Toby L., Marciszewska, Natalia P., Bonten, Marc J. M., Willems, Rob J. L., Bengoechea, Jose A., van Schaik, Willem“…In addition, two E. coli strains had hepta-acylated lipid A species, containing an additional palmitate compared to the canonical hexa-acylated E. coli lipid A. One E. coli strain carried the mobile colistin resistance (mcr) gene mcr-1.1 on an IncX4-type plasmid. …”
Publicado 2020
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23034por Motwani, Keshav, Peters, Leeana D., Vliegen, Willem H., El-sayed, Ahmed Gomaa, Seay, Howard R., Lopez, M. Cecilia, Baker, Henry V., Posgai, Amanda L., Brusko, Maigan A., Perry, Daniel J., Bacher, Rhonda, Larkin, Joseph, Haller, Michael J., Brusko, Todd M.“…Interestingly, expression of canonical Treg markers, such as FOXP3, TIGIT, and IKZF2, were increased in CB CD4(+)CD127(+) conventional T cells (Tconv) compared to APB Tconv, post-expansion, implying perinatal T cells may adopt a default regulatory program. …”
Publicado 2020
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23035por Li, Kaihuai, Hou, Rongxian, Xu, Huiyong, Wu, Guichun, Qian, Guoliang, Wang, Haihong, Liu, Fengquan“…Interestingly, we found an RpfB1 homolog (RpfB2) outside this canonical gene cluster, and nothing is known about its functionality or mechanism. …”
Publicado 2020
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23036por Benito-Martin, Alberto, Paik, Paul, Mushannen, Malik, Bhardwaj, Priya, Oshchepkova, Sonya, Spector, Jason, Brown, Kristy A“…Ingenuity pathway analysis of RNA-Seq data identified significant differences in mTOR signaling and canonical pathways associated with altered mitochondrial function. …”
Publicado 2020
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23037por Moreno-Asso, Alba, McIlvenna, Luke C, Patten, Rhiannon K, McAinch, Andrew J, Rodgers, Raymond J, Stepto, Nigel K“…AMH did not appear to activate the canonical TGFβ/BMP signalling pathway. Conversely, TGFβ1 had an opposite effect in both PCOS and control myotubes cultures, decreasing phosphorylation of IRS1 (ser312) and enhancing glucose uptake via Smad2/3 signalling. …”
Publicado 2020
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23038“…Results: Modeling AR LBD structure flexibility over time revealed possible alternative dynamic structures, including those without ligand, overlaid against the canonical nuclear receptor structure. The model dynamically tracks the structural changes as a ligand enters into the ligand binding domain and nestles into the ligand binding pocket. …”
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23039por Sun, Si, Yang, Qiang, Cai, E, Huang, Bangxing, Ying, Feiquan, Wen, Yiping, Cai, Jing, Yang, Ping“…BACKGROUND: EZH2 acts as an oncogene through canonical pathway EZH2/H3K27Me3 and uncanonical pathway pAkt1/pS21EZH2 in many solid tumors including ovarian cancer. …”
Publicado 2020
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23040“…Nonmetric dimensional scaling of Syndiniales composition revealed tight clustering in June to October that coincided with elevated temperatures (23 to 31°C), though in general, abiotic factors poorly explained composition (canonical correspondence analysis [CCA] and partial least-squares [PLS]) and were less important in the network than biotic relationships. …”
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