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  1. 23101
    “…Receptors [i.e., G protein-coupled receptors (GPCRs)] and their associated transduction mechanisms, well conserved through evolution, specialize in this function. However, canonical GPCR-related signal transduction systems have not been described in Leishmania, although orthologs, with reduced domains and function, have been identified in Trypanosomatidae. …”
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    G Protein-Coupled Receptors as Potential Intercellular Communication Mediators in Trypanosomatidae
  2. 23102
    “…Descriptive statistics, non-parametric Kruskal–Wallis H test followed by the Mann–Whitney U and Dunn-Bonferroni tests for post hoc, Multiple Correspondence Analysis (MCA), Univariate Analysis, Canonical Discriminant Analysis, Categorical Principal Component Analysis and Decision Trees were employed to discern the effects of agro-ecological zone and sex on the morphostructural parameters. …”
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    Multivariate characterisation of morpho-biometric traits of indigenous helmeted Guinea fowl (Numida meleagris) in Nigeria
  3. 23103
    “…Four simple corn hybrids (SYN7G17 TL, 30F53VYHR, B2433PWU, and AG 8700 PRO3) were grown in soils of medium fertility and medium acidity level (UFMS 1) and high fertility and low acidity level (UFMS 2) and fertilized with five of N fertilizer rates (0, 40, 80, 120, and 160 kg ha(–1) of N) applied at 30 days after emergence (DAE). Canonical correlation analysis (CCA) was used to investigate the interrelationships between the groups of independent (agricultural production areas, corn cultivars, and N application rates) and dependent (corn agronomic traits) variables. …”
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    Understanding the contribution of soybean crop residues inoculated with Bradyrhizobium spp. and not harvested on nitrogen supply in off-season corn cultivars
  4. 23104
    “…[Image: see text] Based on the “canonical” view of reactive oxygen species’ (ROS) contribution to carcinogenesis, ROS induce oxidative stress and promote various tumor progression events. …”
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    Harnessing ROS-Induced Oxidative Stress for Halting Colorectal Cancer via Thiazolidinedione-Based SOD Inhibitors
  5. 23105
    “…However, a negative impact of SHD management was evident in environments stressed by summer droughts and conventional tillage: the ratio of obligate plant-parasites to bacterivores and fungivores (Pp/(B+F)) was significantly higher in SHD than in the TRAD olive orchard system, and the prey-to-predator θ mass ratio showed the lowest values in the sites under organic fertilization or green manure. The canonical correspondence analysis showed that the free-living nematodes were only slightly affected by SHD olive orchards; instead, the presence of plant-parasitic nematodes families such as Telotylenchidae, Paratylenchidae, Meloidogynidae, and Criconematidae was favored, in comparison to Longidoridae, Heteroderidae, and Pratylenchidae.…”
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    Impact of Super-High Density Olive Orchard Management System on Soil Free-Living and Plant-Parasitic Nematodes in Central and South Italy
  6. 23106
    “…Chemical-genetic, biochemical, and modeling analyses suggest that CpdLC-6888 inhibits Erg11 in a manner similar to the azoles despite lacking the canonical five-membered nitrogen-containing azole ring. …”
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    High-Throughput Chemical Screen Identifies a 2,5-Disubstituted Pyridine as an Inhibitor of Candida albicans Erg11
  7. 23107
    “…In mammalian cells, this phosphorylation is carried out by a family of eIF2α kinases. A canonical eIF2α translational control system exists in Entamoeba species; however, no eIF2α kinases have been characterized. …”
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    Eukaryotic Initiation Factor 2α Kinases Regulate Virulence Functions, Stage Conversion, and the Stress Response in Entamoeba invadens
  8. 23108
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    Computer-Assisted Surgery Enables Beginner Surgeons, Under Expert Guidance, to Achieve Long-Term Clinical Results not Inferior to Those of a Skilled Surgeon in Knee Arthroplasty
  9. 23109
    “…Seventeen sequences have auxiliary S2' cleavage site located 153 residues downstream the canonically conserved primary furin-specific S1/S2 cleavage site. …”
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    Genome Sequence Variations of Infectious Bronchitis Virus Serotypes From Commercial Chickens in Mexico
  10. 23110
    “…The two encoded PepT2 proteins share 87% identity and resemble both structurally and functionally the canonical vertebrate PepT2 system. The mRNA tissue distribution analyses reveal a widespread distribution of slc15a2a transcripts, being more abundant in the brain and gills, while slc15a2b transcripts are mainly expressed in the kidney and the distal part of the gastrointestinal tract. …”
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    Functional characterization of Atlantic salmon (Salmo salar L.) PepT2 transporters
  11. 23111
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    Clinical Assessment of Introducing Locoregional Anaesthesia Techniques as Part as the Intraoperative Analgesia Management for Canine Ovariohysterectomy in a Veterinary Teaching Hospital
  12. 23112
    “…Our results from the NASH analysis emphasized the role of cholesterol in pathogenesis. Top canonical pathways, disease networks, and disease functions were related to cholesterol synthesis, lipid metabolism, adipogenesis, and metabolic disease. …”
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    Transcriptome changes in stages of non-alcoholic fatty liver disease
  13. 23113
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    The promising role of new molecular biomarkers in prostate cancer: from coding and non-coding genes to artificial intelligence approaches
  14. 23114
    “…The channel-encoding genes, N-methyl-D-aspartate receptor 2D (GRIN2D), transient receptor potential (TRP) ion channel classical or canonical 4 (TRPC4), and TRP ion channel melastatin 2 (TRPM2) demonstrated the greatest increase in expression in OAC in both datasets. …”
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    Alterations in the Ca(2+) toolkit in oesophageal adenocarcinoma
  15. 23115
    “…EsAP2/ERFs covered AP2 (24 genes), DREB (59 genes), ERF (68 genes), and Soloist (2 genes) subfamilies, and lacked canonical RAV subfamily genes based on the widely used classification method. …”
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    Genome-wide investigation of AP2/ERF gene family in the desert legume Eremosparton songoricum: Identification, classification, evolution, and expression profiling under drought stress
  16. 23116
    “…This paper also introduces the adsorption mechanism of plant biomass-derived biochar, where studies based on computational simulations such as the density functional theory, molecular dynamics simulation, and giant canonical Monte Carlo simulation are carefully discussed. …”
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    植物源生物炭材料的制备及其在农药残留领域中的应用进展
  17. 23117
    “…Individual mutations in blaC or genes encoding canonical beta-lactam targets, such as peptidoglycan transpeptidases, are infrequent and do not greatly impact the MICs of potent carbapenem plus clavulanic acid combinations. …”
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    Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing
  18. 23118
    “…Increasing dietary Ca:P decreased duodenal calcium-sensing receptor (CaSR), calbindin-D28k (CaBP-D28k), plasma membrane Ca-ATPase 1 (PMCA1) and sodium-coupled P cotransporter type IIb (NaPi-IIb), but not transient receptor potential canonical 1 (TRPC1) mRNA. This effect was greater with fine limestone when Ca:P increased from low to medium, but greater with coarse limestone when increased from medium to high. …”
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    Mucosal expression of Ca and P transporters and claudins in the small intestine of broilers is altered by dietary Ca:P in a limestone particle size dependent manner
  19. 23119
    “…We discovered five sets of microstates (A–E), including four widely reported canonical microstates (A–D), during baseline and task conditions. …”
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    Electroencephalogram microstates and functional connectivity of cybersickness
  20. 23120
    “…ANOVA analysis showed that the variables significantly differed (p < 0.05) among the ponds, and canonical correspondence analysis (CCA) demonstrated that DO, nitrates, phosphates, sulphates, salinity and transparency have the most impact on the abundance of algal genera. …”
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    Diversity and Assemblage of Harmful Algae in Homestead Fish Ponds in a Tropical Coastal Area
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