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  1. 23141
    “…AIMS: This study aims to compare the performance of a handheld fundus camera (Eyer) and standard tabletop fundus cameras (Visucam 500, Visucam 540, and Canon CR-2) for diabetic retinopathy and diabetic macular edema screening. …”
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    Clinical validation of a smartphone-based retinal camera for diabetic retinopathy screening
  2. 23142
    por Boyd, Robert D., Hayes, Michael L.
    Publicado 2023
    “…Solved crystal structures for DYW-deaminase domains display all structural features consistent with a canonical cytidine deamination mechanism. However, some recombinant DYW-deaminases from plants have been associated with ribonuclease activity in vitro. …”
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    A ribonuclease activity linked to DYW1 in vitro is inhibited by RIP/MORF proteins
  3. 23143
    “…Differences between overlap percentages were assessed through descriptive statistics, ANOVA, post-hoc tests, Pearson’s correlation tests and canonical correlations. Multiple linear and non-linear regression tests were employed to explore relationships with OS. …”
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    Patterns of gray and white matter functional networks involvement in glioblastoma patients: indirect mapping from clinical MRI scans
  4. 23144
    “…The online software Ingenuity Pathway Analysis (IPA) was used to explore activation/inaction of canonical pathways. The hub gene was selected based on the protein-protein interaction (PPI) network constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database and Cytoscape software. …”
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    Astrocyte-derived complement C3 is activated in patients with tuberous sclerosis complex and mediates immune injury: an integrated bioinformatics analysis
  5. 23145
    “…The downstream analysis showed that the identified genes are typically involved in the canonical NFκB-regulated pathways, particularly in adaptive immunity, anti-apoptosis, and cellular response to cytokine stimuli. …”
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    Ensemble learning model for identifying the hallmark genes of NFκB/TNF signaling pathway in cancers
  6. 23146
    “…The scope and complexity of our data imply that DARS2 is potentially involved in transcription regulation beyond its canonical role of aminoacylation. Nevertheless, our work highlights transcript-level dysregulation as a critical, and relatively unexplored, mechanism linking genetic data with neurodegenerative disorders.…”
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    Mutations in DARS2 result in global dysregulation of mRNA metabolism and splicing
  7. 23147
    “…METHODS: We explored the effects of FGF1 on ER-positive endocrine-sensitive and resistant breast cancer and compared that to the effects of the canonical ER ligand, estradiol. We used untargeted proteomics, specific immunoblot assays, gene expression profiling, and functional metabolic assessments of breast cancer cells. …”
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    FGF1 supports glycolytic metabolism through the estrogen receptor in endocrine-resistant and obesity-associated breast cancer
  8. 23148
    “…Introduction: The ζ subunit is a potent inhibitor of the F(1)F(O)-ATPase of Paracoccus denitrificans (PdF(1)F(O)-ATPase) and related α-proteobacteria different from the other two canonical inhibitors of bacterial (ε) and mitochondrial (IF(1)) F(1)F(O)-ATPases. ζ mimics mitochondrial IF(1) in its inhibitory N-terminus, blocking the PdF(1)F(O)-ATPase activity as a unidirectional pawl-ratchet and allowing the PdF(1)F(O)-ATP synthase turnover. ζ is essential for the respiratory growth of P. denitrificans, as we showed by a Δζ knockout. …”
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    Inhibitory to non-inhibitory evolution of the ζ subunit of the F(1)F(O)-ATPase of Paracoccus denitrificans and α-proteobacteria as related to mitochondrial endosymbiosis
  9. 23149
    “…Instead, p53 isoforms, which modulate p53’s canonical function, may be of greater clinical importance. …”
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    It is not all about the alpha: elevated expression of p53β variants is associated with lower probability of survival in a retrospective melanoma cohort
  10. 23150
    “…CONCLUSIONS: The neuropeptide cortistatin has a key role in the physiology of the cerebral microvasculature and its presence is crucial to develop a canonical balanced response to damage. The reparative effects of cortistatin in the brain endothelium were accompanied by the modulation of the immune function and the rescue of barrier integrity. …”
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    Cortistatin deficiency reveals a dysfunctional brain endothelium with impaired gene pathways, exacerbated immune activation, and disrupted barrier integrity
  11. 23151
    “…A brief outlook spotlights the future potential of SiFA radiochemistry within the landscape of non-canonical labeling chemistries.…”
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    Good practices for the automated production of (18)F-SiFA radiopharmaceuticals
  12. 23152
    “…Ingenuity Pathway Analysis (IPA) identified additional sex differences in canonical pathways (e.g., ‘Mitochondrial Dysfunction’, ‘Oxidative Phosphorylation’) and upstream regulators (e.g., CSF3, NFKB complex, TNF, GRIN3A). …”
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    Spatial transcriptomics reveal basal sex differences in supraoptic nucleus gene expression of adult rats related to cell signaling and ribosomal pathways
  13. 23153
    “…We show that EV-H5 act through the canonical TGFβ/SMAD pathway, primarily via miR-302b-3p, which is the most abundant miRNA in EV-H5. …”
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    Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis
  14. 23154
    “…We also confirm that the mTOR pathway is strongly implicated in the pathogenesis of this tumor mainly through MTOR, TCS1, and TSC2 mutations, but other genes could also be involved in the pathway activation, especially in LOTs without “canonical” mutations. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00428-023-03673-9.…”
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    Evaluation of an institutional series of low-grade oncocytic tumor (LOT) of the kidney and review of the mutational landscape of LOT
  15. 23155
    por Huang, R-L, Yuan, Y, Tu, J, Zou, G-M, Li, Q
    Publicado 2014
    “…This inhibitory effect was independent of the canonical BMP/Smad pathway, suggesting the presence of an alternate regulatory pathway for BMP-2-induced Runx2 activity and subsequent osteoblastic differentiation. …”
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    Opposing TNF-α/IL-1β- and BMP-2-activated MAPK signaling pathways converge on Runx2 to regulate BMP-2-induced osteoblastic differentiation
  16. 23156
    por Aguilar, Helena, Urruticoechea, Ander, Halonen, Pasi, Kiyotani, Kazuma, Mushiroda, Taisei, Barril, Xavier, Serra-Musach, Jordi, Islam, Abul, Caizzi, Livia, Di Croce, Luciano, Nevedomskaya, Ekaterina, Zwart, Wilbert, Bostner, Josefine, Karlsson, Elin, Pérez Tenorio, Gizeh, Fornander, Tommy, Sgroi, Dennis C, Garcia-Mata, Rafael, Jansen, Maurice PHM, García, Nadia, Bonifaci, Núria, Climent, Fina, Soler, María Teresa, Rodríguez-Vida, Alejo, Gil, Miguel, Brunet, Joan, Martrat, Griselda, Gómez-Baldó, Laia, Extremera, Ana I, Figueras, Agnes, Balart, Josep, Clarke, Robert, Burnstein, Kerry L, Carlson, Kathryn E, Katzenellenbogen, John A, Vizoso, Miguel, Esteller, Manel, Villanueva, Alberto, Rodríguez-Peña, Ana B, Bustelo, Xosé R, Nakamura, Yusuke, Zembutsu, Hitoshi, Stål, Olle, Beijersbergen, Roderick L, Pujana, Miguel Angel
    Publicado 2014
    “…This effect was probably not due to activation of its canonical target (soluble guanylyl cyclase), but instead was likely a result of binding to ERα. …”
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    VAV3 mediates resistance to breast cancer endocrine therapy
  17. 23157
    “…By restoring Smad4 expression in BxPC3 and silencing it in MiaPaCa2, S100A8 and NT-S100A8 were shown to inhibit NF-κB and Akt in the presence of an intact TGFβ1 canonical signaling pathway. TGFβ1 counteracted S100A8, S100A9 and NT-S100A8 effects in Smad4 expressing, not in Smad4 negative cells, while it synergized with NT-S100A8 in altering Ca(i)(2+) and stimulating PDAC cell growth. …”
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    Inflammation and pancreatic cancer: molecular and functional interactions between S100A8, S100A9, NT-S100A8 and TGFβ1
  18. 23158
    “…However, a high degree of correspondence was observed among gene and protein expression when investigating higher-order functional responses including statistically enriched gene networks and canonical pathways, especially when connected to toxicological outcomes of 2A-DNT exposure. …”
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    Systems toxicology identifies mechanistic impacts of 2-amino-4,6-dinitrotoluene (2A-DNT) exposure in Northern Bobwhite
  19. 23159
    “…BCL9-shRNA knockdown was performed to assess the role of BCL9 in in vivo invasion, epithelial-mesenchymal transition (EMT) and canonical Wnt-signaling. Immunofluorescence of 28 patient samples was used to assess a correlation between the expression of BCL9 and biomarkers of high risk DCIS. …”
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    Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion
  20. 23160
    “…Furthermore, the transcript of the putative substrate of GmIREs, GmbZIP68, harbors a canonical site for IRE1 endonuclease activity and was efficiently spliced under ER stress conditions. …”
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    Comprehensive analysis of the endoplasmic reticulum stress response in the soybean genome: conserved and plant-specific features
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