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  1. 23501
    “…PURPOSE: To determine if prednisolone suppresses or enhances a human M(IL4) phenotype as defined by canonical marker molecules and wound healing and anti-colitic activities. …”
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    A4 PREDNISOLONE, A GLUCOCORTICOID WIDELY USED FOR TREATMENT OF IBD, ENHANCES A HUMAN INTERLEUKIN-4-ACTIVATED MACROPHAGE PHENOTYPE
  2. 23502
    “…In neonates, methylation at over 16,400 CpG methylation sites differed between VLBW cases and controls and the canonical pathway most enriched for these CpGs was Cardiac Hypertrophy Signaling (p = 3.44E(−11)). …”
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    DNA methylation patterns at birth predict health outcomes in young adults born very low birthweight
  3. 23503
    “…METHODS: We generated novel mouse lines harbouring beta cell-specific deletion of either the Rela gene, encoding the canonical NF-κB transcription factor p65 (βp65KO mice), or the Ikbkg gene, encoding the NF-κB essential modulator NEMO (βNEMOKO mice), as well as βA20Tg mice that carry beta cell-specific and forced transgenic expression of the NF-κB-negative regulator gene Tnfaip3, which encodes the A20 protein. …”
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    RELA governs a network of islet-specific metabolic genes necessary for beta cell function
  4. 23504
    “…CONCLUSION: This study revealed the non-canonical molecular mechanism of IL-6 secreted by breast cancer upregulated KDM2A expression in CAFs via a novel STAT3/NFκB p50 axis, which STAT3 complexed with NFκB p50 in NFκB p50 binding motif of KDM2A promoter. …”
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    A novel STAT3/ NFκB p50 axis regulates stromal-KDM2A to promote M2 macrophage-mediated chemoresistance in breast cancer
  5. 23505
    “…Modeling of RT-PCR values reliably categorized the microbiome of IBK and Normal eyes; primers for Moraxella bovoculi, Moraxella bovis, and Staphylococcus spp. were consistently the most significant canonical variables in these models. CONCLUSIONS: The results provide further evidence that multiple elements of the bovine bacterial OSM are altered in the context of IBK, indicating the involvement of a variety of bacteria in addition to Moraxella bovis, including Moraxella bovoculi and R. nasimurium, among others. …”
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    Alterations to the bovine bacterial ocular surface microbiome in the context of infectious bovine keratoconjunctivitis
  6. 23506
    “…Transient receptor potential canonical 6 (TRPC6) is a mechanosensitive channel that is expressed by dorsal root ganglia and glial cells. …”
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    The analgesic action of larixyl acetate, a potent TRPC6 inhibitor, in rat neuropathic pain model induced by spared nerve injury
  7. 23507
    “…CONCLUSIONS: We conclude that the LARGE2 O-glycosyltransferase-encoding gene represents a direct target of canonical Wnt signaling and mediates functional O-glycosylation of α-dystroglycan (α-DG) in human colonic stem/progenitor cells and Wnt-driven CRC. …”
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    Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer
  8. 23508
    “…The WNT2/β-Catenin regulatory pathway is one of the canonical signaling pathways in tumors. It can not only promote the development of tumors but also provide energy for tumor growth through cell metabolism (such as glutamine metabolism). …”
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    Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/β-catenin pathway
  9. 23509
    “…When observing using camera state parameters not interrogated during calibration (e.g., non-canonical zoom positions), we conservatively estimate the absolute uncertainty to be [Formula: see text] . …”
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    Pre-Flight Calibration of the Mars 2020 Rover Mastcam Zoom (Mastcam-Z) Multispectral, Stereoscopic Imager
  10. 23510
    “…METHODS: The diagnostic performance of progranulin was operationalized by calculating AUC and ROC statistics for progranulin and established biomarkers in 241 patients with sepsis, 182 patients with SIRS, 53 patients with CAP, 22 patients with COVID-19 pneumonia and 53 healthy volunteers. miRNAs and mRNAs in blood cells from sepsis patients (n = 7) were characterized by NGS and validated by RT-qPCR in an independent cohort (n = 39) to identify canonical gene networks associated with upregulated progranulin at sepsis onset. …”
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    Progranulin signaling in sepsis, community-acquired bacterial pneumonia and COVID-19: a comparative, observational study
  11. 23511
    “…Furthermore, TM9SF4-depleted cells showed higher activity of canonical Wnt pathway, suggesting the participation of Wnt/β-catenin during TM9SF4-regulated osteogenesis. …”
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    TM9SF4 is a novel regulator in lineage commitment of bone marrow mesenchymal stem cells to either osteoblasts or adipocytes
  12. 23512
    “…The mRNA expressions related to the canonical Wnt/β-catenin signaling pathway, epithelial-mesenchymal transition (EMT) and lymphangiogenesis were detected by RT-qPCR in recurrence tumors and/or lung tissues. …”
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    Effects of plant-based medicinal food on postoperative recurrence and lung metastasis of gastric cancer regulated by Wnt/β-catenin-EMT signaling pathway and VEGF-C/D-VEGFR-3 cascade in a mouse model
  13. 23513
    “…Here, we shed light on the relationship between IL30 and canonical PC driver genes and explored the anti-tumor potential of CRISPR/Cas9-mediated deletion of IL30. …”
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    CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and mortality
  14. 23514
    por ., .
    Publicado 2018
    “…No obstante, el origen de este tipo de arte que, según los cánones tradicionales del teatro y de las artes plásticas, se considera subversivo, se remonta hasta las legendarias veladas futuristas y cabarés dadá de la década de 1910.Para comprender nuevas prácticas se necesitan nuevas teorías, de ahí que en 1980 nacieran los Performance Studies en la Universidad de Nueva York, una posdisciplina que abreva, entre otros campos, en la teatrología, la antropología, los estudios culturales y los estudios de género. …”
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  15. 23515
    “…Variables identified as independently associated with the primary outcome by least absolute shrinkage and selection operator (LASSO) regression, the random survival forest (RSF) algorithm, and univariate and multivariate Cox regression analyses were introduced to establish the following different machine learning models and canonical regression model: support vector machine (SVM), SurvivalTree, Coxboost, RSF, DeepSurv, and Cox proportional hazards (CoxPH). …”
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    Development and validation of machine learning models for predicting prognosis and guiding individualized postoperative chemotherapy: A real-world study of distal cholangiocarcinoma
  16. 23516
    “…Previously, with syngeneic, pairwise transcriptomic analysis, we found a robust upregulation of PPP1R17 in canonically mutated (USP8, USP48 and BRAF) and ‘wildtype’ CD adenomas. …”
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    OR01-02 Epigenomic Dysregulation Of PPP1R17 Drives The Cell Cycle In Adenomas Causing Cushing’s Disease
  17. 23517
    “…Our lab has been exploring the therapeutic potential of a non-canonical AR signaling mechanism wherein AR stimulates another transcription factor, Serum Response Factor (SRF). …”
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    SAT633 The RNA Helicase UPF1 Mediates AR- And SRF-dependent Transcription In Prostate Cancer
  18. 23518
    Publicado 2015
    “…However, Heo Joon did not lean towards a particular theory of medicine; rather, he insisted on establishing a classical medicine (經典醫學) based on the traditional medicinal scriptures such as the Yellow Emperor’s Inner Canon or Shennong’s Classic of Materia Medica, and had created his own Body-Viscera (身形藏府) medicine, as Shin Dongwon’s recent research. …”
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    조선 의관 허준의 임상 의학 사유 엿보기:(*) 『동의보감』에 수록된 임상 사례 및 의안 분석
  19. 23519
    Publicado 2016
    “…The medical knowledge of Wonhyo, Gyeongheung, and Seungjang demonstrates that intellectual circles in contemporary Silla were arenas in which not only traditional East Asian medicine as represented by works such as the Inner Canon of the Yellow Emperor (黃帝內經, Huangdi Neijing) but also Indian medicine of Buddhism coexisted in almost real time.…”
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    신라 승려의 『금광명경』「제병품」 주석을 통해 살펴본 한국 고대 불교의학*
  20. 23520
    por Brand, Richard A.
    Publicado 2008
    “…Girdlestone, Honorary Canon of Christ Church, Oxford [3]. His early education was at Charterhouse, then he read medicine at New College, Oxford. …”
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    Acute Pyogenic Arthritis of the Hip: An Operation Giving Free Access and Effective Drainage: G. R. Girdlestone B M OXFD, F R C S
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