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  1. 23521
    “…DE genes were predicted to significantly decrease synthesis of FA/lipid by both treatments and FA metabolism by LSO. Top canonical pathways associated with DE genes of both treatments might be involved in lipid/cholesterol metabolism. …”
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    Transcriptome adaptation of the bovine mammary gland to diets rich in unsaturated fatty acids shows greater impact of linseed oil over safflower oil on gene expression and metabolic pathways
  2. 23522
    “…CONCLUSIONS: Unique biomarkers and canonical pathways identified in this study may hold the key to understanding mechanisms of DN pathobiology with value for clinical translation. …”
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    Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq
  3. 23523
    “…Because ERBB family mutations can activate the PI3K/AKT pathway and likely have similar canonical signalling effects to PI3K pathway mutations, we investigated their combined impact on response to neoadjuvant HER2-targeted therapies. …”
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    Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies
  4. 23524
    “…The data based on > 1 and 8-fold expression changes of 2136 genes were uploaded into “Ingenuity Pathway Analyses (IPA)” for core analysis, which describes possible canonical pathways, upstream regulators, diseases and functional metabolic networks. …”
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    δ-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients
  5. 23525
    por Ponce, Yovani Marrero
    Publicado 2003
    “…These forms are functions of the k-th power of the molecular pseudograph’s atom adjacency matrix (M). For simplicity, canonical bases are selected as the quadratic forms’ bases. …”
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    Total and Local Quadratic Indices of the Molecular Pseudograph’s Atom Adjacency Matrix: Applications to the Prediction of Physical Properties of Organic Compounds
  6. 23526
    “…These two biomarkers may be used as supplementary biomarkers to canonical diagnostic tools such as biopsy and immunohistochemistry. …”
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    Identification of RPL5 and RPL10 as novel diagnostic biomarkers of Atypical teratoid/rhabdoid tumors
  7. 23527
    “…In agreement, GFP-Lc3 recruitment and host resistance are impaired by deficiency of Rubcn/Rubicon, known as a negative regulator of canonical autophagy and an inducer of LAP. We also found strict dependency on NADPH oxidase, another essential factor for LAP. …”
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    Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model
  8. 23528
    “…MAIN OUTCOMES AND MEASURES: The phenotypic classification of probands and relatives was obtained by applying the Comprehensive Clinical Evaluation Form which classifies patients in the 4 following categories: (1) participants presenting facial and scapular girdle muscle weakness typical of FSHD (category A, subcategories A1-A3), (2) participants with muscle weakness limited to scapular girdle or facial muscles (category B, subcategories B1 and B2), (3) asymptomatic or healthy participants (category C, subcategories C1 and C2), and (4) participants with myopathic phenotypes presenting clinical features not consistent with FSHD canonical phenotype (category D, subcategories D1 and D2). …”
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    Phenotypic Variability Among Patients With D4Z4 Reduced Allele Facioscapulohumeral Muscular Dystrophy
  9. 23529
    “…Our exploratory analysis moreover showed that the mesial frontal lobes, parahippocampal gyrus, and lateral temporal neocortex were at least twice as likely to be functionally connected with the EL_INST compared to the NEL_INST group (i.e. Peak VOR > 2.0); canonical resting-state networks preferentially engaged by EL_INSTs were the Limbic and the Frontoparietal Networks (Mean VOR > 1.5). …”
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    Identification of neural networks preferentially engaged by epileptogenic mass lesions through lesion network mapping analysis
  10. 23530
    por Herrera, Luis A., Hidalgo-Miranda, Alfredo, Reynoso-Noverón, Nancy, Meneses-García, Abelardo A., Mendoza-Vargas, Alfredo, Reyes-Grajeda, Juan P., Vadillo-Ortega, Felipe, Cedro-Tanda, Alberto, Peñaloza, Fernando, Frías-Jimenez, Emmanuel, Arriaga-Canon, Cristian, Ruiz, Rosaura, Angulo, Ofelia, López-Villaseñor, Imelda, Amador-Bedolla, Carlos, Vilar-Compte, Diana, Cornejo, Patricia, Cisneros-Villanueva, Mireya, Hurtado-Cordova, Eduardo, Cendejas-Orozco, Mariana, Hernández-Morales, José S., Moreno, Bernardo, Hernández-Cruz, Irwin A., Herrera, César A., García, Francisco, González-Woge, Miguel A., Munguía-Garza, Paulina, Luna-Maldonado, Fernando, Sánchez-Vizcarra, Antonia, Osnaya, Vincent G., Medina-Molotla, Nelly, Alfaro-Mora, Yair, Cáceres-Gutiérrez, Rodrigo E., Tolentino-García, Laura, Rosas-Escobar, Patricia, Román-González, Sergio A., Escobar-Arrazola, Marco A., Canseco-Méndez, Julio C., Ortiz-Soriano, Diana R., Domínguez-Ortiz, Julieta, González-Barrera, Ana D., Aparicio-Bautista, Diana I., Cruz-Rangel, Armando, Alarcón-Zendejas, Ana Paula, Contreras-Espinosa, Laura, González, Rodrigo, Guerra-Calderas, Lissania, Meraz-Rodríguez, Marco A., Montalvo-Casimiro, Michel, Montiel-Manríquez, Rogelio, Torres-Arciga, Karla, Venegas, Daniela, Juárez-González, Vasti, Guajardo-Barreto, Xiadani, Monroy-Martínez, Verónica, Guillén, Daniel, Fernández, Jacquelina, Herrera, Juliana, León-Rodriguez, Renato, Canela-Pérez, Israel, Ruíz-Ordaz, Blanca H., Valdez-Vazquez, Rafael, Bertin-Montoya, Jennifer, Niembro-Ortega, María, Villegas-Acosta, Liudmila, López-Castillo, Daniela, Soriano-Ríos, Andrea, Gastelum-Ramos, Michael, Zamora-Barandas, Tonatiuh, Morales-Baez, Jorge, García-Rodríguez, María, García-Martínez, Mariano, Nieto-Patlán, Erik, Quirasco-Baruch, Maricarmen, López-Martínez, Irma, Ramírez-Gonzalez, Ernesto, Olivera-Díaz, Hiram, Escobar-Escamilla, Noe
    Publicado 2021
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    Saliva is a reliable and accessible source for the detection of SARS-CoV-2
  11. 23531
    “…BACKGROUND: Wnt genes code for ligands that activate signaling pathways during development in Metazoa. Through the canonical Wnt (cWnt) signaling pathway, these genes regulate important processes in bilaterian development, such as establishing the anteroposterior axis and posterior growth. …”
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    Extensive loss of Wnt genes in Tardigrada
  12. 23532
    “…Intensive bioinformatic studies were performed by analyzing transcriptome through four pairs of comparisons: A) Ly6C(high) vs Ly6C(low) in control mice; B) Ly6C(high) vs Ly6C(low) in ApoE(-/-) mice; C) ApoE(-/-) Ly6C(high) vs control Ly6C(high) MC; D) ApoE(-/-) Ly6C(low) vs control Ly6C(low) MC. A total of 80 canonical pathways and 16 enriched pathways were recognized by top-down analysis using IPA and GSEA software, and further used for overlapping analysis. …”
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    Adaptive Immune Response Signaling Is Suppressed in Ly6C(high) Monocyte but Upregulated in Monocyte Subsets of ApoE (-/-) Mice — Functional Implication in Atherosclerosis
  13. 23533
    “…Here we show mycolactone increased canonical markers of selective macroautophagy/autophagy LC3B-II, ubiquitin and SQSTM1/p62 in diverse disease-relevant primary cells and cell lines. …”
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    Inhibition of the SEC61 translocon by mycolactone induces a protective autophagic response controlled by EIF2S1-dependent translation that does not require ULK1 activity
  14. 23534
    por Zhang, Zhongbo, Xu, Yuanhong
    Publicado 2022
    “…CONCLUSIONS: High FZD7 expression in pancreatic cancer can accelerates hepatic metastases by promoting EMT and strengthening cell stemness, and FZD7 can work through the canonical Wingless-type (WNT) signaling pathway and participate in TGF-β/SMAD3 signaling pathway also.…”
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    FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling
  15. 23535
    “…Here, we report an unbiased genetic screen to isolate Yvh1 variants that fail to displace Mrt4 from pre-60S ribosomes. Bioorthogonal non-canonical amino acid tagging (BONCAT) approaches demonstrate that these YVH1 loss-of-function variants also display defects in nascent protein production. …”
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    Mutational Analyses of the Cysteine-Rich Domain of Yvh1, a Protein Required for Translational Competency in Yeast
  16. 23536
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    Extracellular vesicles from oviductal and uterine fluids supplementation in sequential in vitro culture improves bovine embryo quality
  17. 23537
    “…A 46, XY DSD/complete gonadal dysgenesis DNA panel sequencing identified a novel, dominant, heterozygous, likely pathogenic variant of the NR5A1 gene [c.102+1G>C]. This is a canonical splice donor site of intron 2. CONCLUSION: A novel sequence change in the NR5A1 gene causing a severe phenotype of 46,XY undervirilized male is presented here in a boy originally misdiagnosed with CAH. …”
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    ODP398 A Novel NR5A1 Gene Mutation Causing 46, XY DSD Without Adrenal Insufficiency in an Immigrant Boy from Dominican Republic
  18. 23538
    “…RNAseq data and pathway analysis have indicated the involvement of the canonical nuclear factor kB (NF-kB) signaling pathway. …”
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    A179 MECHANISMS OF ACTION INVOLVED IN THE WOUND HEALING EFFECT OF THE DIETARY FIBRE RHAMNOGALACTURONAN
  19. 23539
    “…This interaction leads to reduced stability of β-catenin by inducing subsequent ubiquitination, thereby suppressing the activation of canonical Wnt signaling. Additionally, we predicted that the m6A reader, YTHDF3, shares common binding sites with hsa-Let-7d-5p. …”
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    Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7
  20. 23540
    “…BACKGROUND: MicroRNAs (miRNAs) and isomiRs play important roles in tumorigenesis as essential regulators of gene expression. 5’isomiRs exhibit a shifted seed sequence compared to the canonical miRNA, resulting in different target spectra and thereby extending the phenotypic impact of the respective common pre-miRNA. …”
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    5’isomiR-183-5p|+2 elicits tumor suppressor activity in a negative feedback loop with E2F1
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