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  1. 3141
    por Lee, Ho-Jin, Shi, De-Li, Zheng, Jie J
    Publicado 2015
    “…The intracellular signaling molecule Dishevelled (Dvl) mediates canonical and non-canonical Wnt signaling via its PDZ domain. …”
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    Conformational change of Dishevelled plays a key regulatory role in the Wnt signaling pathways
  2. 3142
    “…This study demonstrates the importance of the non-canonical Wnt pathway in regulating coordinated ventral cartilage morphogenesis and ossification.…”
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    Distinct requirements of wls, wnt9a, wnt5b and gpc4 in regulating chondrocyte maturation and timing of endochondral ossification
  3. 3143
    “…An alternative low and high ammonium influent regime was proposed and adopted to keep a completely autotrophic nitrogen removal over nitrite (CANON) effective when treating low ammonium wastewater. …”
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    Keeping a Completely Autotrophic Nitrogen Removal over Nitrite System Effective in Treating Low Ammonium Wastewater by Adopting an Alternative Low and High Ammonium Influent Regime
  4. 3144
    por Geyer, Natalie, Gerling, Marco
    Publicado 2021
    “…Such canonical Hh signals largely act as tumor suppressors. …”
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    Hedgehog Signaling in Colorectal Cancer: All in the Stroma?
  5. 3145
    por Olson, Andrew J, Ware, Doreen
    Publicado 2021
    “…However, downstream analyses often operate on only one representative transcript per gene locus, sometimes known as the canonical transcript. To choose canonical transcripts, Transcript Ranking and Canonical Election (TRaCE) holds an ‘election’ in which a set of RNA-seq samples rank transcripts by annotation edit distance. …”
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    Ranked choice voting for representative transcripts with TRaCE
  6. 3146
    por Shah, Kinjal, Kazi, Julhash U.
    Publicado 2022
    “…While WNT ligands usually signal through their dedicated Frizzled receptors, the decision to signal in a β-catenin-dependent or -independent manner rests upon the type of co-receptors used. Canonical WNT signaling is β-catenin-dependent, whereas non-canonical WNT signaling is β-catenin-independent according to the classical definition. …”
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    Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling
  7. 3147
    “…The central CpG dinucleotide in the canonical CRE (TGACGTCA) is critical for strong binding of CREB dimers. …”
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    Evolution of motif variants and positional bias of the cyclic-AMP response element
  8. 3148
    “…We find that isomiRs share sequence and expression characteristics with canonical miRNAs, and are generally strongly correlated with canonical miRNA expression. …”
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    MicroRNAs and their isomiRs function cooperatively to target common biological pathways
  9. 3149
    “…BACKGROUND: The organization of the canonical code has intrigued researches since it was first described. …”
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    A multiobjective approach to the genetic code adaptability problem
  10. 3150
    “…CONCLUSION: Canonical and non-canonical WNT signals act in opposing manners concerning determining CD8αα(+) IELs immune status. …”
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    WNT5A transforms intestinal CD8αα(+) IELs into an unconventional phenotype with pro-inflammatory features
  11. 3151
    “…A combined downregulation of the canonical and non-canonical pathways further suppressed TNFα levels and inhibited Smac mimetic-mediated cell death. …”
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    PKC activation sensitizes basal-like breast cancer cell lines to Smac mimetics
  12. 3152
    “…The first canonical function was significant (p<0.05), accounted for 72.46% of the total variance, and the canonical correlation was 0.56, indicating the dependence between both groups of traits. …”
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    Multivariate analysis of body morphometric traits in conjunction with performance of reproduction and milk traits in crossbred progeny of Murrah × Jafarabadi buffalo (Bubalus bubalis) in North-Eastern Brazil
  13. 3153
    “…Additionally, 3564 RBPs were classified into canonical and non-canonical RBPs depending on the domains that they contain, and non-canonical RBPs account for the majority (72.95%). …”
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    Integrated Analysis of RNA-Binding Proteins in Glioma
  14. 3154
    por Chitta, Madhavi, Malathi, Lekshmi
    Publicado 2023
    “…Background  The Neoclassical canons, originally framed based on the Renaissance artworks, vary across genders, races, and ages. …”
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    Facial Anthropometric Analysis of a Representative Subset in an Average Kerala Population: A Pilot Study
  15. 3155
    “…Alternative mitophagy is functional regardless of whether the canonical autophagic mechanism is intact or disrupted. …”
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    Erythroleukemia cells acquire an alternative mitophagy capability
  16. 3156
    “…While many studies have demonstrated that canonical NF-κB signaling is a central pathway in lung tumorigenesis, the role of non-canonical NF-κB signaling in lung cancer remains undefined. …”
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    p52 expression enhances lung cancer progression
  17. 3157
    “…By applying this method to MERS-CoV, the 11 canonical cleavage sites were readily identified and verified by the biochemical assays. …”
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    Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus
  18. 3158
    “…Mounting evidence suggests that these PPIs include both “canonical” interactions, which are universally conserved, and “non-canonical” (or “secondary”) contacts that seem to have emerged in eukaryotes. …”
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    Multivalent protein–protein interactions are pivotal regulators of eukaryotic Hsp70 complexes
  19. 3159
    por Testa, M
    Publicado 1972
    “…Considerations on Regge couplings in hadron-hadron scattering and deep inelastic electroproduction are shown to be suggested by canonical light cone expansion. The particular case in which no canonical scalar fields are present is examined in detail. (12 refs).…”
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    Light cone current algebra and Regge couplings
  20. 3160
    “…Chimeric Wnts bearing modular linker “grafts” were able to transfer LRP6 domain specificity between different Wnts and enable non-canonical Wnt5a to signal through the canonical pathway. …”
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    Structure of the Wnt–Frizzled–LRP6 initiation complex reveals the basis for coreceptor discrimination
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