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3281“…The weak gravity conjecture (WGC) for scalar potentials is saturated in the supercritical string scenarios discussed in this work, but only if one uses the dilaton as appears in the string effective action, with a kinetic term that is not canonically normalized. In the case of a noncritical Starobinsky potential, the WGC is satisfied by both the canonically normalized dilaton and the dilaton used in the string effective action.…”
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3282“…Activation can be induced via two distinct pathways, the canonical and non-canonical pathway, which result in tumor cell proliferation, survival and drug resistance. …”
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3283“…The HBV circular genome encodes only four overlapping reading frames, encoding for the main canonical proteins named core, P, surface, and X (or HBx protein). …”
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3284por Pavlenko, Anastasiia, Lasota, Sławomir, Wnuk, Dawid, Paw, Milena, Czyż, Jarosław, Michalik, Marta, Madeja, Zbigniew“…These responses were related to the activity of TGF-β signalling, as the electrotaxis and re-orientation of NA HBF polarity was impaired by the inhibitors of canonical and non-canonical TGF-β-dependent pathways. …”
Publicado 2023
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3285“…Tyrosine and di-leucine-based sorting signals are such canonical motifs. Connexin 43 (Cx43) has three canonical tyrosine-based endocytic motifs, two of which have been previously shown to recruit clathrin and mediate its endocytosis. …”
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3286por Arita, Masashi, Suematsu, Takuma, Osanai, Arihiro, Inaba, Takashi, Kamiya, Haruo, Kita, Kiyoshi, Sisido, Masahiko, Watanabe, Yoh-ichi, Ohtsuki, Takashi“…Neither of the EF-Tus can bind to canonical cloverleaf tRNAs. In this study, by analyzing the translation system of enoplean nematode Trichinella species, we address how EF-Tus and tRNAs have evolved from the canonical structures toward those of the chromadorean translation system. …”
Publicado 2006
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3287por Blanco-Colio, Luis M.“…Finally, we highlight the results obtained with other members of the TNF superfamily that also activate canonical and non-canonical NF-κB pathway.…”
Publicado 2014
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3288“…Surprisingly, however, we find here that aggregating individual gene expression using canonical metabolic pathways fails to enhance the classification of noncancerous vs. cancerous tissues and the prediction of cancer patient survival. …”
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3289“…Consistently, depletion of CD147 by CRISPR/Cas9 technique in GC-2 cells down-regulated TRAF2 and resulted in cell death with suppressed canonical NFκB and activated non-canonical NFκB signaling. …”
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3290por Bartakova, Alena, Kuzmenko, Olga, Alvarez-Delfin, Karen, Kunzevitzky, Noelia J., Goldberg, Jeffrey L.“…CONCLUSIONS: HCECs isolated from donor corneas and expanded in vitro with a low-mitogenic media stabilizing step before each passage demonstrate more canonical structural and functional features and defer EnMT, increasing the number of passages and total canonical cell yield. …”
Publicado 2018
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3291por Zaliova, Marketa, Winkowska, Lucie, Stuchly, Jan, Fiser, Karel, Triska, Petr, Zwyrtkova, Martina, Hrusak, Ondrej, Starkova, Julia, Sramkova, Lucie, Stary, Jan, Trka, Jan, Zuna, Jan“…Cases with this signature, but without canonical ZNF384 fusions (ZNF384r-like cases), have been described previously. …”
Publicado 2021
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3292“…Proper functioning of the aaRSs to create aminoacylated (or “charged”) tRNAs is required for efficient and accurate protein synthesis. Beyond their basic canonical function in protein biosynthesis, aaRSs have a surprisingly diverse array of non-canonical functions that are actively being defined. …”
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3293por Greenfeld, Hannah, Takasaki, Kaoru, Walsh, Michael J., Ersing, Ina, Bernhardt, Katharina, Ma, Yijie, Fu, Bishi, Ashbaugh, Camille W., Cabo, Jackson, Mollo, Sarah B., Zhou, Hufeng, Li, Shitao, Gewurz, Benjamin E.“…The LMP1 membrane-proximal TES1/CTAR1 domain recruits TRAFs to activate MAP kinase, non-canonical and canonical NF-kB pathways, and is critical for EBV-mediated B-cell transformation. …”
Publicado 2015
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3294“…Here we summarize non-canonical roles of p16, including our recent finding on its role in nucleotide metabolism.…”
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3295“…Transforming growth factor-beta (TGFβ) belongs to a large family of growth factors that elicit diverse cellular responses via canonical and non-canonical signaling pathways. Canonical SMAD-dependent signaling pathways are required to coordinate changes in homing receptor expression as CTLs traffic between different tissues. …”
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3296“…The canonical Wnt signaling pathway is critical for development of the mammalian central nervous system and regulates diverse processes throughout adulthood, including adult neurogenesis. …”
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3297por Iozzi, Sara, Remelli, Rosaria, Lelli, Barbara, Diamanti, Daniela, Pileri, Silvia, Bracci, Luisa, Roncarati, Renza, Caricasole, Andrea, Bernocco, Simonetta“…Background. DKK1 antagonizes canonical Wnt signalling through high-affinity binding to LRP5/6, an essential component of the Wnt receptor complex responsible for mediating downstream canonical Wnt signalling. …”
Publicado 2012
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3298por Hecht, Ariel, Glasgow, Jeff, Jaschke, Paul R., Bawazer, Lukmaan A., Munson, Matthew S., Cochran, Jennifer R., Endy, Drew, Salit, Marc“…Translation from non-canonical start codons ranged from 0.007 to 3% relative to translation from AUG. …”
Publicado 2017
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3299“…In several interneuron types, all functions are carried out by dendrites as these neurons are devoid of a canonical axon. In this article, we present a few examples of “misbehaving” neurons (with a non-canonical polarity scheme) to highlight the diversity of solutions that are used by mammalian neurons to transmit information. …”
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3300por Black, Katrina A., He, Sitong, Jin, Ruitao, Miller, David M., Bolla, Jani R., Clarke, Oliver B., Johnson, Paul, Windley, Monique, Burns, Christopher J., Hill, Adam P., Laver, Derek, Robinson, Carol V., Smith, Brian J., Gulbis, Jacqueline M.“…The canonical mechanistic model explaining potassium channel gating is of a conformational change that alternately dilates and constricts a collar-like intracellular entrance to the pore. …”
Publicado 2020
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