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  1. 3321
    “…Sharing the N‐terminal exons with the canonical IRF9 proteins, PS‐IRF9 is predicted to bind to the same DNA sequences as the canonical IRF9 proteins. …”
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    Evolution and emergence of primate‐specific interferon regulatory factor 9
  2. 3322
    “…We find that amxFabZ displays distinct sequence differences to “canonical” FabZ, such as a bulky, apolar residue on the inside of the substrate-binding tunnel, where the canonical enzyme has a glycine. …”
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    Structures of an unusual 3-hydroxyacyl dehydratase (FabZ) from a ladderane-producing organism with an unexpected substrate preference
  3. 3323
    “…These analyses returned communities that contained known canonical signalling components. Interestingly, in addition to canonical PI3K/AKT/mTOR members, the community assignments returned TTK (also known as MPS1) as a likely component of PI3K/AKT/mTOR signalling. …”
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    Community detection in empirical kinase networks identifies new potential members of signalling pathways
  4. 3324
    “…Increasing evidence has supported the role of ceramide as a mediator of photoreceptor dysfunction or cell death in ceramide accumulation and deficiency contexts. TLCD3B, a non-canonical ceramide synthase, was previously identified in addition to the six canonical ceramide synthases (CerSs), and the Tlcd3b(−/−) mouse model exhibited both retinal dysfunction and degeneration. …”
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    Ceramide compensation by ceramide synthases preserves retinal function and structure in a retinal dystrophy mouse model
  5. 3325
    “…The humanized yeast strains display robust prenyltransferase activity that functionally replaces yeast prenyltransferase activity in a wide array of tests, including the prenylation of a wide variety of canonical and non-canonical human CaaX sequences, virus encoded CaaX sequences, non-canonical length sequences, and heterologously expressed human proteins HRas and DNAJA2. …”
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    A Humanized Yeast System for Evaluating the Protein Prenylation of a Wide Range of Human and Viral CaaX Sequences
  6. 3326
    “…BACKGROUND: While the role of canonical (β-catenin-mediated) Wnt signaling in hematolymphopoiesis has been studied extensively, little is known of the potential importance of non-canonical Wnt signals in hematopoietic cells. …”
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    Wnt4 Enhances Murine Hematopoietic Progenitor Cell Expansion Through a Planar Cell Polarity-Like Pathway
  7. 3327
    “…Our study identified both in vitro and in vivo enhanced endogenous canonical Wnt signaling in frontal bone compared with parietal bone. …”
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    Origin Matters: Differences in Embryonic Tissue Origin and Wnt Signaling Determine the Osteogenic Potential and Healing Capacity of Frontal and Parietal Calvarial Bones
  8. 3328
    “…Evolutionary changes of the canonical Wnt/β-catenin signaling pathway may lead to innovation of jaws.…”
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    Asymmetric Requirement of Surface Epithelial β-Catenin During the Upper and Lower Jaw Development
  9. 3329
    “…Loss of Wnt3 and Wnt3a prevents induction of the MDO, a phenotype also observed upon blockage of canonical Wnt signaling per se. Pharmaceutical activation of the canonical Wnt pathways in Wnt3/Wnt3a compound morphant embryos is able to restore the lack of the MDO. …”
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    Wnt3 and Wnt3a are required for induction of the mid-diencephalic organizer in the caudal forebrain
  10. 3330
    “…CONCLUSIONS: We demonstrated that the 1(st )non-canonical EF-hand of NOX5 has very weak Ca(2+ )binding affinity compared with the 2(nd )canonical EF-hand. …”
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    Characterization of the 1(st )and 2(nd )EF-hands of NADPH oxidase 5 by fluorescence, isothermal titration calorimetry, and circular dichroism
  11. 3331
    “…These processes are tightly regulated by canonical Wnt signaling. Low levels of active canonical Wnt signaling enable endochondral ossification and therefore PF-suture closure, whereas constitutive activation of canonical Wnt causes PF-suture patency. …”
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    Absence of Endochondral Ossification and Craniosynostosis in Posterior Frontal Cranial Sutures of Axin2(−/−) Mice
  12. 3332
    “…Cerebella were used for molecular and biochemical analysis of insulin/IGF-1, canonical Wnt, and Notch signaling mechanisms. RESULTS: Prenatal ethanol exposures impaired rotarod performance, inhibited signaling through insulin and IGF-1 receptors, IRS-1, and Akt, increased activation of GSK-3β, and broadly suppressed genes mediating the canonical Wnt and Notch networks. …”
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    Motor Function Deficits Following Chronic Prenatal Ethanol Exposure are Linked to Impairments in Insulin/IGF, Notch and Wnt Signaling in the Cerebellum
  13. 3333
    “…We tested the hypothesis that Emilin1 deficiency results in AVD, mediated by non-canonical (MAPK/phosphorylated Erk1 and Erk2) TGF-β dysregulation. …”
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    TGF-β mediates early angiogenesis and latent fibrosis in an Emilin1-deficient mouse model of aortic valve disease
  14. 3334
    por Xu, Wenlong, Wang, Zixing, Liu, Yin
    Publicado 2014
    “…We have also introduced four additional non-canonical types of seed matches beyond the canonical seed matches, and included them in our study. …”
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    The Characterization of microRNA-Mediated Gene Regulation as Impacted by Both Target Site Location and Seed Match Type
  15. 3335
    “…PKA-Wnt crosstalk in the cells was bi-directional, including enhanced interactions between β-catenin and the cAMP-responsive element binding protein (CREB) and transcriptional crosstalk between the Wnt and PKA signaling pathways. Increases in canonical Wnt/β-catenin signaling were associated with a decrease in the activity of the non-canonical Wnt/Ror2 pathway, which has been shown to antagonize canonical Wnt signaling. …”
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    Protein Kinase A Activation Enhances β-Catenin Transcriptional Activity through Nuclear Localization to PML Bodies
  16. 3336
    “…Here we discuss the neuroprotective role of the canonical and non-canonical Wnt signaling pathways in AD and their differential modulation of mitochondrial processes, associated with mitochondrial dysfunction and neurodegeneration.…”
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    How the Wnt signaling pathway protects from neurodegeneration: the mitochondrial scenario
  17. 3337
    “…We quantified intermediates in canonical and non-canonical TGFβ pathways and observed a significant increase in the levels of the non-canonical pathway mediator p-JNK in the DBA iPSCs. …”
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    Dysregulation of the Transforming Growth Factor β Pathway in Induced Pluripotent Stem Cells Generated from Patients with Diamond Blackfan Anemia
  18. 3338
    por Maida, Yoshiko, Masutomi, Kenkichi
    Publicado 2015
    “…In this review, we discuss the non‐canonical functions of TERT and their potential applications for anticancer treatment.…”
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    Telomerase reverse transcriptase moonlights: Therapeutic targets beyond telomerase
  19. 3339
    “…It comprises central elements (the apex of d10, d11 and the following polypyrimidine tract) that are homologous to corresponding elements in canonical Type 1 IRESs, and non-canonical flanking domains (d8, d9 and d12). …”
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    Initiation on the divergent Type I cadicivirus IRES: factor requirements and interactions with the translation apparatus
  20. 3340
    por Langer, Simon, Sauter, Daniel
    Publicado 2017
    “…In total, HIV-1 expresses 16 canonical proteins from only nine genes within its 10 kb genome. …”
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    Unusual Fusion Proteins of HIV-1
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