“…These findings suggest that, for native listeners, the canonicity of the variant form is an important determiner of ease of recognition, even in the absence of orthographic or perceptual motivations for the primacy of canonical variants for this particular example of variation. …”
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“…Effect of these changes with pharmacological inhibitors of canonical and non-canonical TGF pathway was done to analyze the pathway involved. …”
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“…In this review, therefore, several observations from different studies are presented to support this paradigm linking cardiac OS, the canonical and non-canonical pathways of necroptosis, and ischemia-induced injury. …”
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“…Because the ancestors of both mammals and insects reproduced by internal fertilization, we hypothesized that the transition from two centrioles with canonical composition in ancestral sperm to an atypical centriolar composition characterized by only one canonical centriole evolved preferentially after internal fertilization. …”
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“…Results: The main results include: 1) hairpins containing the canonical and non-canonical NSP15 cleavage motifs are canonical and non-canonical transcription regulatory sequence (TRS) hairpins; 2) TRS hairpins can be used to identify recombination regions in CoV genomes; 3) RNA methylation participates in the determination of the local RNA structures in CoVs by affecting the formation of base pairing; and 4) The eventual determination of the CoV RTC global structure needs to consider METTL3 in the experimental design. …”
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“…Due to the equality of redundancy in the second canonical component, the direction of influence can only be inferred on the basis of the first canonical component. …”
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“…These molecule and filament IHM variants have important energetic and pathophysiological consequences. (1) The canonical motif, with S2–head interaction, correlates with the super-relaxed (SRX) state of myosin. …”
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“…Some plausibly argue the increased rate of production of information results in an ossification of the canon. Reports, challenging the canon, fall by the wayside. …”
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“…They play an important role within physiological and pathological cellular processes by regulating an estimated 60% of all protein-coding genes. miRNAs are produced quickly through canonical or non-canonical pathways involving many steps and proteins. …”
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“…Together, these findings provide one of the first investigations examining the interactions between the eCS and its non‐canonical receptor systems in vertebrate motor development.…”
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“…In addition, Calabria Omicron presented 16 non-canonical mutations in the S protein and 151 non-canonical mutations in non-structural proteins. …”
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“…At the end, several sets of distortion parameters and stable camera interior orientation (IO) parameters act as the final camera calibration results. The Canon and GoPro in-air calibration experiments show that GoPro owns distortions seven times larger than Canon. …”
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“…With respect to TGF-β2 signaling, recombinant TGF-β2 induced phosphorylation of canonical signaling proteins Smad2/3 but did not alter phosphorylation of non-canonical signaling proteins extracellular signal-regulated kinases (ERK)1/2, p38, and c-Jun N-terminal kinases (JNK)1/2 proteins in ONH astrocytes and LC cells. …”
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“…The first two canonical variate pairs yielded interpretable squared canonical correlation (Rc(2)) effect sizes of 74.7% and 55.8%, respectively. …”
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“…Nedd4 (Nedd4-1) is an E3 ubiquitin ligase involved in crucial biological processes such as growth factor receptor signaling. While canonical Nedd4-1 comprises a C2-WW((4))-HECT domain architecture, alternative splicing produces non-canonical isoforms that are poorly characterized. …”
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“…BACKGROUND: The canonical Wnt signalling pathway is activated in most sporadic colorectal cancers (CRCs). …”
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“…Both SCZ and BD had dysregulated mRNA expression of Wnt-related genes favoring attenuated canonical (beta-catenin-dependent) signaling, and there were also indices of enhanced non-canonical Wnt signaling. …”
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“…In HTLV-1-infected T-cells, CADM1 expression is dependent on HTLV-1/Tax through activation of canonical and non-canonical NF-κB; however, in ATLL cells with frequent loss of Tax expression, the activation of canonical NF-κB only enhances the CADM1 expression. …”
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“…IsomiR analysis revealed that almost 40% of the total miRNA pool was composed by non-canonical sequences. Metformin significantly affects the relative abundance of 133 isomiRs, including the non-canonical forms of the aforementioned miRNAs. …”
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“…Notably, some dimers feature non-canonical inter-subunit contacts absent in the initial hTRiC. …”
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