“…Both broadly-reactive canonical and pathogen-selected non-canonical Vδ1 clones contributed to memory responses to Lm and STm. …”
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“…We show that Sfrp5 inhibits both canonical and non-canonical Wnt signaling during embryonic and endodermal development, resulting in endodermal abnormalities.…”
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“…One hypothesis is that the traditional analysis of pain-related cerebral responses, by relying on the correlation of a predictor and the canonical hemodynamic response function (HRF)- the general linear model (GLM)- may under-detect the activity of those areas involved in stimulus processing that do not present a canonical HRF. …”
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“…This approach can be generally applied to dissecting the biochemistry of DNA repair at non-canonical DNA structures.…”
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“…Organ formation is achieved through the complex interplay between signaling pathways and transcriptional cascades. The canonical Wnt signaling pathway plays multiple roles during embryonic development including patterning, proliferation and differentiation in distinct tissues. …”
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“…The heart parenchyma comprises specialized cardiomyocytes (CMs). CMs have been canonically classified into a few phenotypically diverse subpopulations largely based on their function and anatomic localization. …”
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“…In ASD, the increase of the canonical WNT/β-catenin pathway is enhancing by the dysregulation of circadian rhythms. …”
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“…On the nucleosome-positioning 601 DNA sequence, we observe a rich transition network among various canonical and non-canonical tetrasome, hexasome, and nucleosome conformations. …”
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“…Neural processing is hypothesized to apply the same mathematical operations in a variety of contexts, implementing so-called canonical neural computations. Divisive normalization (DN) is considered a prime candidate for a canonical computation. …”
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“…A FZD4 chimera, in which the linker was swapped with that of the non-canonical receptor FZD6, impairs the binding with WNT3A and suppresses the recruitment of LRP6 and Disheveled, resulting in reduced canonical signaling. …”
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“…However, non-canonical VPS34-independent autophagy has also been proposed. …”
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“…GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. …”
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“…The general form of the nonrelativistic action and the theory of canonical transformations are considered. For a general action, the Jacobian matrices of the canonical transformations acting on N Grassmann variables form a group O/sub N, N/. …”
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“…The latter implicitly assumes that the canonical variables describe observables, entailing necessarily the regularity of their exponentials (Weyl operators). …”
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“…The associated antibracket and its canonical structure appear naturally if one integrates out the corresponding ghost fields. …”
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“…We validated the performance of our methods versus the two canonical approaches for detection of GS/CB artefact, respectively, on 26 healthy human EEG-functional MRI resting-state datasets. …”
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“…Our results imply that proteins secreted during adulthood by the canonical secretory pathway from female reproductive glands are needed to store sperm, while a non-canonical glandular secretion stimulates ovulation. …”
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“…Recently, a rapidly emerging paradigm has revealed GIV/Girdin as a central platform for receptor cross-talk which integrates signals downstream of a myriad of cell surface receptors, and modulates several key pathways within downstream signaling network, all via non-canonical activation of trimeric G proteins. Unlike canonical signal transduction via G proteins, which is spatially and temporally restricted, the temporal and spatial features of non-canonical activation of G protein via GIV is unusually unrestricted. …”
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“…On the basis of selected examples, we discuss the consequences of non-canonical metabolic reactivity on evolution, function and repair of the metabolic network.…”
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