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  1. 3581
    “…Candidates as low as 0.45 Å RMSD and with a worst case of 3.66 Å were produced. For the canonical loops like the immunoglobulin complementarity-determining regions (mean RMSD <2.0 Å), the DPM-HMM method performs as well or better than the best templates, demonstrating that our automated method recaptures these canonical loops without inclusion of any IgG specific terms or manual intervention. …”
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    Near-Native Protein Loop Sampling Using Nonparametric Density Estimation Accommodating Sparcity
  2. 3582
    “…In particular, the energetic contribution of secondary structure interactions is now well documented, but the quantification of non-canonical interactions—those shaping the tertiary structure—is poorly understood. …”
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    Towards 3D structure prediction of large RNA molecules: an integer programming framework to insert local 3D motifs in RNA secondary structure
  3. 3583
    “…The identified canonical pathways were largely overlapping between individual runs. …”
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    Pathway analysis and transcriptomics improve protein identification by shotgun proteomics from samples comprising small number of cells - a benchmarking study
  4. 3584
    “…There were Warburg type, reverse Warburg type, mixed type, and null type in glucose-dependent metabolism, and canonical type, non-canonical type, mixed type, null type in glutamine-dependent metabolism. …”
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    Metabolic Phenotypes in Pancreatic Cancer
  5. 3585
    “…BACKGROUND: Recently, structured sparse canonical correlation analysis (SCCA) has received increased attention in brain imaging genetics studies. …”
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    Structured sparse CCA for brain imaging genetics via graph OSCAR
  6. 3586
    “…In particular Ror1/2 receptors and several other members of the non-canonical Wnt signaling pathway were associated with aggressive breast cancer behavior. …”
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    Ror2 Signaling and Its Relevance in Breast Cancer Progression
  7. 3587
    “…The non‐canonical pore exists in the native TRPM3 channel and can be activated by co‐stimulation of the endogenous agonist pregnenolone sulphate and the antifungal drug clotrimazole or by stimulation of the synthetic agonist CIM0216. …”
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    Mutations in the voltage‐sensing domain affect the alternative ion permeation pathway in the TRPM3 channel
  8. 3588
    “…The semantically annotated data repository is comprised of a canonical data dictionary, data sources with a data dictionary, and mappings between each individual data dictionary and the canonical data dictionary. …”
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    X-search: an open access interface for cross-cohort exploration of the National Sleep Research Resource
  9. 3589
    “…Conformational analysis shows that the canonical PDZ domain is stable while the βN extension presents high flexibility in all systems, especially for M5P. …”
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    Molecular Dynamics Simulations of Wild Type and Mutants of SAPAP in Complexed with Shank3
  10. 3590
    “…NF-κB can be activated through either canonical or non-canonical pathways. In the canonical pathway, activation of NF-κB is normally negatively regulated by the inhibitor IκB. …”
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    Reduced IκB-α Protein Levels in Peripheral Blood Cells of Patients with Multiple Sclerosis—A Possible Cause of Constitutive NF-κB Activation
  11. 3591
    “…AIMS: The canonical Wnt signaling pathway plays an essential role in blood‐brain barrier integrity and intracerebral hemorrhage in preclinical stroke models. …”
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    Variants of WNT7A and GPR124 are associated with hemorrhagic transformation following intravenous thrombolysis in ischemic stroke
  12. 3592
    “…In contrast, LNO-CCSD(T) converges smoothly to the canonical CCSD(T) answer with increasingly tight convergence settings. …”
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    The MOBH35 Metal–Organic Barrier Heights Reconsidered: Performance of Local-Orbital Coupled Cluster Approaches in Different Static Correlation Regimes
  13. 3593
    “…However, such strategies suffer from missing the non-canonical target sites. The aim of this study is to identify the general features of non-canonical targets and their interactions with microRNAs. …”
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    An Alternative Class of Targets for microRNAs Containing CG Dinucleotide
  14. 3594
    “…Indeed, somatic mutations are identified in key components of canonical and non-canonical Wnt signaling and in PLCs and precancerous lesions. …”
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    Targeting Wnt/β-Catenin Pathways in Primary Liver Tumours: From Microenvironment Signaling to Therapeutic Agents
  15. 3595
    “…Differences in the patterns of gene diversification and subfamilies expansion were observed across subfamilies. Genes encoding canonical OePIN proteins comprise six exons, while genes encoding non-canonical OePINs are composed of five exons, with implications for protein specificities and functionality. …”
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    Understanding the Role of PIN Auxin Carrier Genes under Biotic and Abiotic Stresses in Olea europaea L.
  16. 3596
    “…Autorefractometer measurements with cycloplegia were performed with Canon RK-F1 autorefractometer, Nidek Tonoref III and Retinomax K-Plus 3, and spherical and cylindrical values were recorded. …”
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    Comparison of the results of four different refraction measurement devices in children with retinoscopy
  17. 3597
    por Jürgens, Lara, Wethmar, Klaus
    Publicado 2022
    “…SIMPLE SUMMARY: The biological relevance of peptides that originate from non-canonical translational initiation sites have been increasingly recognized over the years. …”
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    The Emerging Role of uORF-Encoded uPeptides and HLA uLigands in Cellular and Tumor Biology
  18. 3598
    “…Here, we describe three methods applying bioorthogonal non-canonical amino acid tagging and fluorescent non-canonical amino acid tagging to quantify protein synthesis in microglia. …”
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    Three methods for examining the de novo proteome of microglia using BONCAT bioorthogonal labeling and FUNCAT click chemistry
  19. 3599
    “…Our results suggest that a non-canonical mode of RNA splicing, resulting in a circular RNA isoform, is a general feature of the gene expression program in human cells.…”
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    Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types
  20. 3600
    “…This is one of the major developmental pathways, regulated both canonically and non-canonically. Deregulation of the pathway during development leads to a number of developmental malformations, depending on the deregulated pathway component. …”
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    Role of GLI Transcription Factors in Pathogenesis and Their Potential as New Therapeutic Targets
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