“…Upon virus infection, pluripotent stem cells neither induce nor respond to canonical type I interferons (IFN-I). To better understand this biology, we characterized induced pluripotent stem cells (iPSCs) as well as their differentiated parental or rederived counterparts. …”
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“…We demonstrated that in LNCaP, PCa cells’ SHMT2 expression is upregulated by the JAK2/STAT3 canonical pathway upon IL-6 stimulation. Activation of SHTM2 leads to a decrease in serine levels, pushing PKM2 towards the nuclear compartment where it can activate STAT3 in a non-canonical fashion that in turn promotes a transient shift toward anaerobic metabolism. …”
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“…The results showed that, regardless of the modifying position, greater activation in the LIFG was consistently elicited in Chinese subject-extracted relative clauses (SRCs) with non-canonical word order than object-extracted relative clauses (ORCs) with canonical word order, implying that the LIFG subserving the ordering process primarily contributes to the processing of information with increased integration demands due to the non-canonical sequence. …”
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“…SA requires the autophagic pathway and both, secretory autophagy and canonical degradative autophagy are at the same time, integrated and highly regulated processes that interact in ultimate cross-talking molecular mechanisms. …”
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“…An effect of NTS and MSM on canonical and PKC-dependent NF-κB pathways was also demonstrated by western blotting. …”
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“…Mechanistically, pyroptosis can be categorized into canonical (mediated by caspase-1) and non-canonical (mediated by caspase-4/5/11). …”
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“…The performance in comparison to canonical CCSD(T) is assessed in detail. It was found that spin-state splittings with chemical accuracy, compared to the canonical results, are achieved when the full iterative triples (T(1)) scheme and TightPNO settings are applied and relativistic effects are taken into account. …”
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“…Three major and distinct Wnt signalling pathways have been characterized: the canonical Wnt pathway (or Wnt/β-catenin pathway), the non-canonical planar cell polarity pathway and the non-canonical Wnt/Ca(2+) pathway. …”
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“…Specifically, Fascin promotes cell motility, invasion, and adhesion by forming filopodia and invadopodia through its canonical actin bundling function. In addition to bundling actin, Fascin has non-canonical roles in the cell that are thought to promote cell migration. …”
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“…However, many bacteria are found on surfaces, even though they lack features required for migrating along surfaces. How these canonical non‐motile bacteria adapt to the environmental fluctuations on surfaces remains unknown. …”
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“…One mutation at the noncanonical face was also found to suppress defects of several other canonical and noncanonical site mutations in ZipA, suggesting there is some interdependence between the two sites. …”
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“…The Wnt signaling pathway is comprised of the canonical, or Wnt/β-catenin, and the non-Canonical signaling pathway. …”
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“…Canonical and noncanonical Wnt signaling pathways are essential for development and maintenance of the CNS. …”
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“…Transcriptional coactivator PGC-1α is a main regulator of cardiac energy metabolism. In addition to canonical PGC-1α1, other PGC-1α isoforms have been found to exert specific biological functions in a variety of tissues. …”
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“…BHRF1 engages BH3 peptides using the canonical ligand-binding groove of its Bcl-2 fold and maintains a salt bridge between an Arg residue with a conserved Asp residue in the BH3 motif mimicking the canonical ionic interaction seen in host Bcl-2:BH3 motif complexes. …”
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“…Data were analyzed using descriptive statistics, t-test, one-way analysis of variance (ANOVA), Pearson’s correlation coefficients, and canonical correlations. Two significant canonical variates were found. …”
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“…Comammox Nitrospira’s ecological success is evident as they outnumber and present higher species-level richness than canonical Nitrospira in all environments examined, except for marine and wastewaters samples. …”
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“…We also consider non-canonical mechanisms of EBV-induced host shutoff. Finally, we summarize the limitations and barriers to accurate measurements of the EBV host shutoff phenomenon.…”
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“…Pyroptosis, a form of programmed cell death which has recently received much attention, is closely related to inflammation and occurs via canonical, non-canonical, caspase-3-dependent, and unclassified pathways. …”
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“…The cell and gene therapy industry has employed the same plasmid technology for decades in vaccination, cell and gene therapy, and as a raw material in viral vector and RNA production. While canonical plasmids contain antibiotic resistance markers in bacterial backbones greater than 2,000 base pairs, smaller backbones increase expression level and durability and reduce the cell-transfection-associated toxicity and transgene silencing that can occur with canonical plasmids. …”
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