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  1. 3801
    “…The sperm's specialized centrosome consists of the canonical barrel-shaped proximal centriole, the funnel-shaped distal centriole, and the pericentriolar material known as striated columns (or segmented columns). …”
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    CP110 and CEP135 localize near the proximal and distal centrioles of cattle and human spermatozoa
  2. 3802
    “…The experimental results present evidence that the canonical sequence motives of the SYFPEITHI database on their own are insufficient for predicting MHC I protein stabilization.…”
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    MHC I Stabilizing Potential of Computer-Designed Octapeptides
  3. 3803
    por Kishimoto, Koshi N., Itoi, Eiji
    Publicado 2013
    “…The effect of canonical Wnt/β-catenin signaling on chondrogenic differentiation induced by transfection of BMP4 expressing plasmid was analyzed. …”
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    Lithium Chloride Enhances Cathepsin H Expression and BMP-4 Degradation in C3H10T1/2 Cells
  4. 3804
    “…Furthermore, we analyzed the interaction of PTPSL with ERK2 showing that residues outside of the canonical KIM motif also contribute to ERK2 binding. …”
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    Interaction of Kinase-Interaction-Motif Protein Tyrosine Phosphatases with the Mitogen-Activated Protein Kinase ERK2
  5. 3805
    por Falk, Richard S, Winther, Ragnar
    Publicado 2015
    “…These so-called bounded cochain projections have been constructed by combining a smoothing operator and the unbounded canonical projections defined by the degrees of freedom. …”
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    Double complexes and local cochain projections
  6. 3806
    “…Over the last decade, sexual motivation has been used as a good canonical working model to study motivated social interactions. …”
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    Freezing Behavior as a Response to Sexual Visual Stimuli as Demonstrated by Posturography
  7. 3807
    “…In addition to the role of ROCK in different cell types such as neurons and microglia, we focus on the molecular signaling-pathways which mediate the beneficial effects of ROCK. Besides canonical ROCK signaling, modulation of neighboring pathways by non-canonical ROCK-crosstalk is a recurrent pattern in many NDD-model systems and has been suggested to mediate beneficial effects of ROCK-inhibition.…”
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    Chatting with the neighbors: crosstalk between Rho-kinase (ROCK) and other signaling pathways for treatment of neurological disorders
  8. 3808
    “…Canonical Wnt-signalling is well understood and has been extensively described in many developmental processes. …”
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    Expression Pattern of Axin2 During Chicken Development
  9. 3809
    “…Our work highlights BCL9 and Pygo as selective β-catenin cofactors in a subset of canonical Wnt responses during vertebrate development. …”
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    Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling
  10. 3810
    “…The newly identified splicing transcript encodes a shorter protein compared to the canonical EGR1. This isoform lacks a region belonging to the N-terminal activation domain and although it is capable of entering the nucleus, it is unable to activate transcription fully relative to the canonical isoform.…”
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    Identification, Characterization, and Regulatory Mechanisms of a Novel EGR1 Splicing Isoform
  11. 3811
    “…In the past few years, it has become clear that IRE1 plays canonical and non-canonical roles in APCs, many of which intersect with key features of these cells, including the initiation of inflammation, antibody production, and antigen presentation. …”
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    Understanding the Role of the Unfolded Protein Response Sensor IRE1 in the Biology of Antigen Presenting Cells
  12. 3812
    “…We then demonstrate site-specific incorporation of these non-canonical, backbone-extended monomers at the N- and C- terminus of peptides using wild-type and engineered ribosomes. …”
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    Ribosome-mediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro
  13. 3813
    por Jakubík, Jan, El-Fakahany, Esam E.
    Publicado 2021
    “…Cholesterol binds to many GPCRs at both canonical and non-canonical binding sites. It allosterically affects ligand binding to and activation of GPCRs. …”
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    Allosteric Modulation of GPCRs of Class A by Cholesterol
  14. 3814
    “…Signaling through LTβR is comprised of both the canonical and non-canonical-nuclear factor κB (NF-κB) pathways, which induce chemokines, cytokines, and cell adhesion molecules. …”
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    LTβR Signaling Controls Lymphatic Migration of Immune Cells
  15. 3815
    “…ATM is among of the most critical initiators and coordinators of the DNA-damage response. ATM canonical and non-canonical signaling pathways involve hundreds of downstream targets that control many important cellular processes such as DNA damage repair, apoptosis, cell cycle arrest, metabolism, proliferation, oxidative sensing, among others. …”
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    ATM: Main Features, Signaling Pathways, and Its Diverse Roles in DNA Damage Response, Tumor Suppression, and Cancer Development
  16. 3816
    “…They orchestrate an immune response by cleaving specific cellular substrates. Canonical inflammasomes activate caspase-1, whereas non-canonical inflammasomes activate caspase-4 and -5 in humans and caspase-11 in mice. …”
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    Great balls of fire: activation and signalling of inflammatory caspases
  17. 3817
    por Yang, Chen, Qi, Yan, Sun, Zhitang
    Publicado 2021
    “…At present, the SHH signaling pathway can be divided into the canonical signaling pathway and non-canonical signaling pathway, which directly or indirectly mediates other related pathways involved in the development of neurodegenerative diseases. …”
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    The Role of Sonic Hedgehog Pathway in the Development of the Central Nervous System and Aging-Related Neurodegenerative Diseases
  18. 3818
    “…Among many mechanisms described, heat shock proteins were proposed as universally conserved protective factors in the stress core proteome, coping with different stress stimuli through its canonical role in protein homeostasis. However, emerging evidences reveal non-canonical roles of heat shock proteins relevant for physiological and pathological conditions. …”
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    Neural functions of small heat shock proteins
  19. 3819
    “…In this review, we focus on the function of SUMOylation in canonical and non-canonical TGF-β signalling and its role in fibrosis, providing promising therapeutic strategies for fibrosis.…”
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    Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis
  20. 3820
    “…Metabolites are prone to damage, either via enzymatic side reactions, which collectively form the underground metabolism, or via spontaneous chemical reactions. The resulting non-canonical metabolites that can be toxic, are mended by dedicated “metabolite repair enzymes.” …”
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    Approaches for completing metabolic networks through metabolite damage and repair discovery
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