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  1. 3821
    “…MicroRNAs (miRNAs) are synthesized through a canonical pathway and play a role in human diseases, such as cancers and cardiovascular, neurodegenerative, psychiatric, and chronic inflammatory diseases. …”
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    EpisomiR, a New Family of miRNAs, and Its Possible Roles in Human Diseases
  2. 3822
    por Cetto, Ana Maria, de la Peña, Luis
    Publicado 2022
    “…In particular, we demonstrate that in parallel with the evolution of the canonical variables of the particle into quantum operators satisfying the basic commutator [Formula: see text] , also the field canonical variables are transformed, giving rise to the corresponding creation and annihilation operators [Formula: see text] , satisfying [Formula: see text]. …”
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    The Electromagnetic Vacuum Field as an Essential Hidden Ingredient of the Quantum-Mechanical Ontology
  3. 3823
    “…Aberrant translation, a characteristic feature of cancer, is regulated by the complex and sophisticated RNA binding proteins (RBPs) in the canonical translation machinery. N6-methyladenosine (m(6)A) modifications are the most abundant internal modifications in mRNAs mediated by methyltransferase-like 3 (METTL3). …”
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    Critical Roles of METTL3 in Translation Regulation of Cancer
  4. 3824
    “…Lentiviral vector expression of canonical Wnt3a and non-canonical Wnt5a in eASCs was associated with induced and suppressed osteogenic differentiation, respectively, whilst treatment of eNOS-osteogenic cells with the Wnt inhibitor Dkk-1 significantly reduced expressions of Runx2 and ALP. …”
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    Molecular control of nitric oxide synthesis through eNOS and caveolin-1 interaction regulates osteogenic differentiation of adipose-derived stem cells by modulation of Wnt/β-catenin signaling
  5. 3825
    por Scheck, Florian
    Publicado 2010
    “…This book covers all topics in mechanics from elementary Newtonian mechanics, the principles of canonical mechanics and rigid body mechanics to relativistic mechanics and nonlinear dynamics. …”
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    Mechanics: From Newton's Laws to Deterministic Chaos
  6. 3826
    “…The content focuses on the existence problem for canonical Kähler metrics and links to the algebro-geometric notion of K-stability. …”
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    Moduli of K-stable varieties
  7. 3827
    “…Therefore, it is critically important to understand the canonical as well as non-canonical functions of telomerase through TERT to develop a therapeutic strategy against telomerase-related diseases. …”
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    Current Insights to Regulation and Role of Telomerase in Human Diseases
  8. 3828
    por Canon, M D
    Publicado 1982
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    Storage systems and technology: status and future directions
  9. 3829
    “…However, Lepidoptera (moths and butterflies) undergo 3 distinct meiotic processes, only one of which is canonical. Lepidoptera males utilize 2 meiotic processes: canonical meiosis that produces nucleated fertile sperm, and a noncanonical meiosis that produces anucleated nonfertile sperm which are nonetheless essential for reproduction. …”
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    A molecular cell biology toolkit for the study of meiosis in the silkworm Bombyx mori
  10. 3830
    “…Heterotrimeric G (αβγ) proteins are canonical transducers of G-protein-coupled receptor (GPCR) signaling and play critical roles in communication between cells and their environment. …”
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    The G protein alpha Chaperone and Guanine-Nucleotide Exchange Factor RIC-8 Regulates Cilia Morphogenesis in Caenorhabditis elegans Sensory Neurons
  11. 3831
    “…Statistical comparison of the functional constraints imposed on the canonical and non-canonical PBC containing sequences reveals that a key arginine, which coordinates with the cAMP phosphate, has co-evolved with a glycine in a distal β2-β3 loop that allosterically couples cAMP binding to distal regulatory sites. …”
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    Evolution of allostery in the cyclic nucleotide binding module
  12. 3832
    “…This new element consists of a canonical E-box or a non-canonical E-box and an E-box-like sequence in tandem with the latter with a short interval, 6 base pairs, between them. …”
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    A direct repeat of E-box-like elements is required for cell-autonomous circadian rhythm of clock genes
  13. 3833
    “…Deletions relative to the canonical N2 strain are more common in these isolates than duplications, and indels are enriched in multigene families on the autosome arms. …”
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    Copy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans
  14. 3834
    por Pantazis, Antonios, Olcese, Riccardo
    Publicado 2012
    “…This information contributes spatial constraints for understanding the BK channel voltage-sensing process, revealing the structural rearrangements in a non-canonical VSD.…”
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    Relative transmembrane segment rearrangements during BK channel activation resolved by structurally assigned fluorophore–quencher pairing
  15. 3835
    “…Here, we confirm the presence of a similar (ARN)(x) motif in glmS RNA, a gene controlled by two sRNAs (GlmZ and GlmY) in an Hfq-dependent manner. GlmZ represents a canonical sRNA:mRNA pairing system, whereas GlmY is non-canonical, interfacing with the RNA processing protein YhbJ. …”
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    Requirement of upstream Hfq-binding (ARN)(x) elements in glmS and the Hfq C-terminal region for GlmS upregulation by sRNAs GlmZ and GlmY(†)
  16. 3836
    “…Differential models describe the dynamics of the TGF-β canonical pathway, but modeling the non-canonical networks constitutes a major challenge. …”
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    An integrative modeling framework reveals plasticity of TGF-β signaling
  17. 3837
    “…We identified a non-canonical preprotein without the classical transit peptide, the superoxide dismutase (FSD1), which was then used in chemical crosslinking approaches to find new interaction partners at the outer envelope from pea chloroplasts. …”
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    A new member of the psToc159 family contributes to distinct protein targeting pathways in pea chloroplasts
  18. 3838
    “…Here, we demonstrate that a protonated cytidine can functionally and structurally replace the uridine at the first position of the canonical U-turn motif in the apical loop of the neomycin riboswitch. …”
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    Building a stable RNA U-turn with a protonated cytidine
  19. 3839
    “…The Microprocessor plays an essential role in canonical miRNA biogenesis by facilitating cleavage of stem-loop structures in primary transcripts to yield pre-miRNAs. …”
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    Global identification of target recognition and cleavage by the Microprocessor in human ES cells
  20. 3840
    “…These genes were enriched in GO terms and canonical pathways associated with immune system functions, particularly phagocytosis. …”
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    Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression
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