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  1. 3841
    “…The software identifies canonical and noncanonical base pairs, including those with modified nucleotides, in any tautomeric or protonation state. …”
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    DSSR: an integrated software tool for dissecting the spatial structure of RNA
  2. 3842
    “…This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease. We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness, tumorigenesis, and cancer drug resistance. …”
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    Wnt/β-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance
  3. 3843
    “…In addition to canonical initiation factors, the canonical Type 1 and divergent cadicivirus IRESs require the same IRES trans-acting factor, poly(C)-binding protein 2 (PCBP2). …”
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    PCBP2 enables the cadicivirus IRES to exploit the function of a conserved GRNA tetraloop to enhance ribosomal initiation complex formation
  4. 3844
    “…Western blot analysis indicated that Wnt7a induced both canonical Wnt signaling and NFAT and Akt non-canonical signaling. …”
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    Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis
  5. 3845
    “…The study suggested that Hh/Gli1 cascade (canonical pathway) as well as Gsk3β-Gli1 crosstalk (non-canonical pathway) play crucial role in estrogen-dependent cell proliferation in endometrial hyperplasia.…”
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    The regulation of Hh/Gli1 signaling cascade involves Gsk3β- mediated mechanism in estrogen-derived endometrial hyperplasia
  6. 3846
    “…Alternative selection of 5′ splice sites (SSs) of DOK7 intron 4 generates canonical and frame-shifted transcripts. We found that the canonical full-length Dok-7 enhanced AChR clustering, whereas the truncated Dok-7 did not. …”
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    SRSF1 suppresses selection of intron-distal 5′ splice site of DOK7 intron 4 to generate functional full-length Dok-7 protein
  7. 3847
    por Miall, R. Chris, Haggard, P., Cole, J. D.
    Publicado 2017
    “…The central canonical position does not appear to be reached by either maximal co-contraction or by complete relaxation, but may have been reached by matched low-level co-contraction.…”
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    Control of wrist movement in deafferented man: evidence for a mixed strategy of position and amplitude control
  8. 3848
    “…CONCLUSIONS: The anti-aging hormone Klotho counteracts aberrant canonical Wnt signaling in muscle stem cells and might be one of the naturally occurring inhibitors of canonical Wnt signaling in skeletal muscle. …”
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    Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle
  9. 3849
    “…In the past few years, canonical microRNA variants (isomiRs) have been shown to play pivotal roles by acting as regulators of the transcriptional machinery. …”
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    Diff isomiRs: Large-scale detection of differential isomiRs for understanding non-coding regulated stress omics in plants
  10. 3850
    “…Knockdown of endogenous INHBA repressed the expression of EGFR and inhibited activin A-mediated canonical Smads, noncanonical phosphorylation of AKT (ser473) (p-AKT ser473) and SP1. …”
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    Activin A regulates the epidermal growth factor receptor promoter by activating the PI3K/SP1 pathway in oral squamous cell carcinoma cells
  11. 3851
    “…Non-canonical pathways, by contrast, mainly regulate cell polarization and migration, in particular convergent extension movements of the trunk mesoderm during gastrulation. …”
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    Lef1 regulates caveolin expression and caveolin dependent endocytosis, a process necessary for Wnt5a/Ror2 signaling during Xenopus gastrulation
  12. 3852
    “…The canonical correlation coefficient was 0.642, with a Wilk’s lambda value of 0.78 and p < 0.001. …”
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    Multimarker Approach to Identify Patients with Coronary Artery Disease at High Risk for Subsequent Cardiac Adverse Events: The Multi-Biomarker Study
  13. 3853
    “…Therefore, the finding here indicates the urgency of developing pathway-specific inhibitors that only suppress canonical FGF, but not non-canonical FGF21, signaling for alleviating inflammation in the liver, which is presented in all stages of diseased liver.…”
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    Disruption of FGF Signaling Ameliorates Inflammatory Response in Hepatic Stellate Cells
  14. 3854
    “…Further examination uncovered that hyperactivation of canonical Wnt pathway disturbed trophoblast differentiation in the EPC via repressing Ascl2 expression. …”
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    Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2
  15. 3855
    “…Wnt family member 8B (Wnt8B), one of the canonical Wnt ligands, is implicated in oncogenesis. …”
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    Wnt8B, transcriptionally regulated by ZNF191, promotes cell proliferation of hepatocellular carcinoma via Wnt signaling
  16. 3856
    “…Dcr1 of the RNAi pathway and Iec1 of Ino80C both promote HAATI(rDNA) formation as part of their respective canonical machineries, but both also inhibit formation of the exceedingly rare HAATI(STE) (where STE sequences mobilize throughout the genome and assume chromosome end protection capacity) in non-canonical, pathway-independent manners. …”
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    RNAi and Ino80 complex control rate limiting translocation step that moves rDNA to eroding telomeres
  17. 3857
    “…Second, genic smORFs were classified as smORFs located in non-coding RNAs (ncRNAs) or canonical mRNAs. Finally, smORFs in ncRNAs were further subdivided into sequences located in small or long RNAs, whereas smORFs located in canonical mRNAs were subdivided into several specific classes depending on their localization along the gene. …”
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    Understanding small ORF diversity through a comprehensive transcription feature classification
  18. 3858
    “…Genetic analyses in yeast indicate that not all of their functions require the canonical complex. The lack of systematic genetic analyses in plants and animals, however, makes it difficult to discern whether PFDs participate in a process as the canonical complex or in alternative configurations, which is necessary to understand their mode of action. …”
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    A genetic approach reveals different modes of action of prefoldins
  19. 3859
    “…PCID2 promoted canonical Wnt/β-catenin signaling in CRC via degradation of PML. …”
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    A novel amplification gene PCI domain containing 2 (PCID2) promotes colorectal cancer through directly degrading a tumor suppressor promyelocytic leukemia (PML)
  20. 3860
    “…Our recent data showed that the canonical WNT/β-Catenin pathway serves a subordinate role in RMS, whereas non-canonical WNT signaling probably is more important for this tumor entity. …”
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    Tumor suppressive functions of WNT5A in rhabdomyosarcoma
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