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  1. 3861
    “…The Cancer Genome Atlas (TCGA) database has been used to confirm the roles played by 10 canonical oncogenic signaling pathways in various cancers. …”
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    Identification of genes from ten oncogenic pathways associated with mortality and disease progression in glioblastoma
  2. 3862
    “…CPEB2–4 mRNA targets include CPEB1-bound transcripts, with canonical CPEs, but also a specific subset of mRNAs with non-canonical CPEs. …”
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    Comparative analyses of vertebrate CPEB proteins define two subfamilies with coordinated yet distinct functions in post-transcriptional gene regulation
  3. 3863
    “…The goal of this review is to highlight canonical and non-canonical mechanisms whereby DDRs contribute to kidney injury/fibrosis. …”
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    Genetic and pharmacological tools to study the role of discoidin domain receptors in kidney disease
  4. 3864
    “…Thus, we have identified new substrates of the non-canonical inflammasomes and reveal key mechanistic details regulating inflammation.…”
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    The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases
  5. 3865
    por Salvio, Alberto, Strumia, Alessandro
    Publicado 2015
    “…We find that a 4-derivative degree of freedom involves a canonical coordinate with unusual time-inversion parity, and that a correspondingly unusual representation must be employed for the relative quantum operator. …”
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    Quantum mechanics of 4-derivative theories
  6. 3866
    por Mccullough, Matthew
    Publicado 2017
    “…Consider a general 4D action involving scalar (φ), fermion (ψ), and vector gauge fields (A µ), normalised such that all kinetic terms and commutation relations are canonical. In our basis, there are no explicit factors of in the classical Lagrangian in position space. …”
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    A Clockwork Theory
  7. 3867
    “…[Image: see text] Whereas modern proteins rely on a quasi-universal repertoire of 20 canonical amino acids (AAs), numerous lines of evidence suggest that ancient proteins relied on a limited alphabet of 10 “early” AAs and that the 10 “late” AAs were products of biosynthetic pathways. …”
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    Early Selection of the Amino Acid Alphabet Was Adaptively Shaped by Biophysical Constraints of Foldability
  8. 3868
    “…Canonical Wnt signaling plays a major role in regulating microbial pathogenesis. …”
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    β-Catenin Elicits Drp1-Mediated Mitochondrial Fission Activating the Pro-Apoptotic Caspase-1/IL-1β Signalosome in Aeromonas hydrophila-Infected Zebrafish Macrophages
  9. 3869
    “…In the next step, the canonical MP2 correlation energy is obtained in the same orbital basis. …”
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    MP2-Based Correction Scheme to Approach the Limit of a Complete Pair Natural Orbitals Space in DLPNO-CCSD(T) Calculations
  10. 3870
    “…Based on the viewpoint effect in Experiments 1a and 1b, we could empirically determine the most canonical and noncanonical viewpoints from our set of viewpoints to use in Experiment 2. …”
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    Viewpoint dependence and scene context effects generalize to depth rotated three-dimensional objects
  11. 3871
    por Mikels, Amanda J, Nusse, Roel
    Publicado 2006
    “…In addition to the canonical pathway, evidence for several other Wnt signaling pathways has accumulated, in particular for Wnt5a, which has therefore been classified as a noncanonical Wnt family member. …”
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    Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context
  12. 3872
    “…With the addition of two and three water molecules, the energy differences between the zwitterions and corresponding canonical isomers were calculated at 3.13 and −1.54 kcal mol(−1), respectively. …”
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    A Proline-Based Neuraminidase Inhibitor: DFT Studies on the Zwitterion Conformation, Stability and Formation
  13. 3873
    “…β-Defensins comprise a family of cationic, antimicrobial and chemoattractant peptides. The six cysteine canonical motif is retained throughout evolution and the disulphide connectivities stabilise the conserved monomer structure. …”
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    Defensin-related peptide 1 (Defr1) is allelic to Defb8 and chemoattracts immature DC and CD4(+) T cells independently of CCR6
  14. 3874
    “…In addition, we found that Hedgehog (Hh) signaling was activated by canonical Wnt signaling and imposed a negative feedback on the latter. …”
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    Wnt Signaling Is Required for Early Development of Zebrafish Swimbladder
  15. 3875
    “…Recently, logical models of canonical pathways have been optimised with high-throughput phosphoproteomic data to construct cell-type specific pathways. …”
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    Combined logical and data-driven models for linking signalling pathways to cellular response
  16. 3876
    “…Meckel's cartilage is expanded in the Fuz(−/−) mice due to increased cell proliferation associated with the up-regulation of Wnt canonical target genes and decreased non-canonical pathway genes. …”
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    Fuz Regulates Craniofacial Development through Tissue Specific Responses to Signaling Factors
  17. 3877
    “…As expected, when NIK was depleted there was decreased activation of the non-canonical NF-κB pathway, while canonical NF-κB activation remained intact. …”
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    NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway
  18. 3878
    “…During kidney development, canonical Wnt signaling activates differentiation, while the transcription factor Six2 maintains the progenitor pool. …”
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    Conditional Expression of Wnt9b in Six2-Positive Cells Disrupts Stomach and Kidney Function
  19. 3879
    por Xia, Jing, Zhang, Weixiong
    Publicado 2012
    “…These noncanonical miRNAs exhibited features distinct from that of canonical miRNAs in lengths of hairpins, base pairings and first nucleotide preference. …”
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    Noncanonical MicroRNAs and Endogenous siRNAs in Lytic Infection of Murine Gammaherpesvirus
  20. 3880
    “…BACKGROUND: Identification of canonical pathways through enrichment of differentially expressed genes in a given pathway is a widely used method for interpreting gene lists generated from high-throughput experimental studies. …”
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    PathNet: a tool for pathway analysis using topological information
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