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3941“…Canonical Wnt signalling, governed by its effector β-catenin, is known for a long time as playing an important role in development, tissue homeostasis, and cancer. …”
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3942por Ye, Jixing, Yang, Tian, Guo, Haiying, Tang, Yinhong, Deng, Fang, Li, Yuhong, Xing, Yizhan, Yang, Li, Yang, Ke“…Previous research has revealed that Wnt10b activates canonical Wnt signaling, which is integral to melanocyte differentiation in hair follicles (HFs). …”
Publicado 2013
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3943por Jung, H, Kim, B-G, Han, W H, Lee, J H, Cho, J-Y, Park, W S, Maurice, M M, Han, J-K, Lee, M J, Finley, D, Jho, E-h“…Dishevelled (Dvl) is a key regulator of Wnt signaling both in the canonical and non-canonical pathways. Here we report the identification of a regulatory domain of ubiquitination (RDU) in the C-terminus of Dvl. …”
Publicado 2013
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3944“…His most important medical works are the Canon of Medicine medical encyclopedia and a treatise on cardiac drugs. …”
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3945“…In T lymphocytes, p38 MAP kinase (MAPK) regulates pleiotropic functions and is activated by canonical MAPK signaling or the alternative T cell receptor (TCR) activation pathway. …”
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3946por Katagiri, Naohiro, Kuroda, Takao, Kishimoto, Hiroyuki, Hayashi, Yuki, Kumazawa, Takuya, Kimura, Keiji“…In contrast, NPM was not required for canonical autophagy induced by nutrient starvation, as it was not accompanied by nucleolar disruption. …”
Publicado 2015
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3947por Charbonnier, Louis-Marie, Wang, Sen, Georgiev, Peter, Sefik, Esen, Chatila, Talal A“…Expression in T(reg) cells of gain of function transgene encoding Notch1 intracellular domain resulted in lymphoproliferation, exacerbated T(H)1 responses and autoimmunity. Cell-intrinsic canonical Notch signaling impaired T(reg) cell fitness, promoted the acquisition by T(reg) cells of a T(H)1 cell-like phenotype, whereas Rictor-dependent non-canonical Notch signaling activated the AKT-Foxo1 axis and impaired Foxp3 epigenetic stability. …”
Publicado 2015
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3948por Xu, Shujuan, Li, Qian, Xiang, Junfeng, Yang, Qianfan, Sun, Hongxia, Guan, Aijiao, Wang, Lixia, Liu, Yan, Yu, Lijia, Shi, Yunhua, Chen, Hongbo, Tang, Yalin“…This paper presents the development of such a method, a new technique using a cyanine dye called CyT, which can detect both canonical and non-canonical RNA G4 structures from test tubes to living human cells. …”
Publicado 2015
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3949“…The vacuolar H(+) -ATPase (V-ATPase) is a rotary motor enzyme that acidifies intracellular organelles and the extracellular milieu in some tissues. Besides its canonical proton-pumping function, V-ATPase’s membrane sector, V(o), has been implicated in non-canonical functions including membrane fusion and neurotransmitter release. …”
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3950por Miller, Sophie R., Perera, Surangi N., Benito, Cristina, Stott, Simon R. W., Baker, Clare V. H.“…In the Schwann cell lineage, the transition from multipotent Schwann cell precursor to immature Schwann cell is promoted by canonical Notch signalling. Here, in situ hybridisation and immunohistochemistry data from chicken, mouse and human embryos are presented that suggest a canonical Notch‐mediated transition also occurs during OEC development.…”
Publicado 2016
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3951por Rinkenbaugh, Amanda L., Cogswell, Patricia C., Calamini, Barbara, Dunn, Denise E., Persson, Anders I., Weiss, William A., Lo, Donald C., Baldwin, Albert S.“…Interestingly, both the canonical and non-canonical branches of the NF-κB pathway are shown to contribute to this phenotype. …”
Publicado 2016
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3952“…In this review, we discuss recent advances in understanding how canonical and non-canonical PERK-mediated signaling pathways influence cell fate, tumor progression, and tumor suppression and avenues for therapeutic intervention.…”
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3953“…This apparent affinity matches that for its canonical dsDNA ligand, suggesting a biological role for RNA binding by SMAD3.…”
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3954por Belgacem, Yesser H., Hamilton, Andrew M., Shim, Sangwoo, Spencer, Kira A., Borodinsky, Laura N.“…Shh signaling is particularly dynamic in the nervous system, ranging from canonical transcription-dependent, to non-canonical and localized to axonal growth cones. …”
Publicado 2016
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3955“…Because 7SL is not associated with the canonical proteins of the SRP, it could represent a nonfunctional remnant of the protein synthetic machinery. …”
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3956por Röttger, Katharina, Stellmacher, Rebecca, Stuhldreier, Mayra C., Temps, Friedrich“…The mechanism likely involves an out-of-plane deformation of the five-membered ring, different from the main electronic deactivation pathways in the canonical purine bases adenine and guanine. The results are discussed in terms of the structural and electronic differences of XMP compared to the canonical nucleotides.…”
Publicado 2017
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3957“…The present review highlights recent advances made in the field of SHH signaling in endothelial progenitor cells (EPCs). The canonical and non-canonical SHH signaling pathways in EPCs and endothelial cells (ECs) related to homeostasis, SHH signal transmission by extracellular vesicles (EVs) or exosomes containing single-strand non-coding miRNAs and impaired SHH signaling in cardiovascular diseases are discussed. …”
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3958“…In this review, we summarize recent findings, supporting the role of Hippo signaling in SRPDs by canonical and non-canonical Hippo pathway interactions.…”
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3959“…This review summarizes the recently obtained insights into metabolic differences of the known nitrifiers and discusses these in light of potential functional adaptation and niche differentiation between canonical and complete nitrifiers. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00253-018-9486-3) contains supplementary material, which is available to authorized users.…”
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3960“…However, basolateral sorting remained intact in mutated channels lacking those signals, suggesting that non-canonical signals reside elsewhere. Our study demonstrates intrinsic basolateral sorting of CALHM channels in polarized cells, and provides mechanistic insights.…”
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