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  1. 3961
    por Owiti, Norah, Stokdyk, Kasey, Kim, Nayun
    Publicado 2018
    “…Non-canonical residue in DNA is a major and conserved source of genome instability. …”
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    The etiology of uracil residues in the Saccharomyces cerevisiae genomic DNA
  2. 3962
    “…In this study, we show that local activation of the canonical Wnt pathway regulates neuronal polarity and axonal outgrowth. …”
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    Wnt Signaling Directs Neuronal Polarity and Axonal Growth
  3. 3963
    “…This is particularly evident in the case of monoterpenoid production in Saccharomyces cerevisiae, where the canonical terpene precursor geranyl diphosphate is tightly coupled to the biosynthesis of isoprenoid compounds essential for yeast viability. …”
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    Orthogonal monoterpenoid biosynthesis in yeast constructed on an isomeric substrate
  4. 3964
    “…ProtMiscuity contains information about canonical and promiscuous activities comprising 88 different reactions in 57 proteins from 40 different organisms. …”
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    ProtMiscuity: a database of promiscuous proteins
  5. 3965
    “…The molecular clock of P. hawaiensis lacks orthologs of the canonical circadian genes cryptochrome 1 and timeless, in common with the mammalian system but in contrast to many arthropods including Drosophila melanogaster. …”
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    In silico Identification of a Molecular Circadian System With Novel Features in the Crustacean Model Organism Parhyale hawaiensis
  6. 3966
    “…In this review we discuss the coupled-clock pacemaker system and how its manipulation by neurohumoral signaling alters heart rate, considering the multitude of canonical and non-canonical agents that are known to modulate sinoatrial node activity. …”
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    Neurohumoral Control of Sinoatrial Node Activity and Heart Rate: Insight From Experimental Models and Findings From Humans
  7. 3967
    “…Signaling pathways that activate these transcription factors are intertwined at the level of the canonical IκB kinases (IKKα, IKKβ) and non-canonical IKK-related kinases (IKKɛ, TBK1). …”
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    IκB kinase ɛ (IKKɛ): A therapeutic target in inflammation and cancer
  8. 3968
    “…In this review, we focus on genetically inherited chronic kidney diseases and dissect the links between canonical and non-canonical Wnt signalling, and this umbrella of conditions that result in kidney damage. …”
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    The Role of Wnt Signalling in Chronic Kidney Disease (CKD)
  9. 3969
    “…To discover driver fusions beyond canonical exon-to-exon chimeric transcripts, we develop CICERO, a local assembly-based algorithm that integrates RNA-seq read support with extensive annotation for candidate ranking. …”
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    CICERO: a versatile method for detecting complex and diverse driver fusions using cancer RNA sequencing data
  10. 3970
    “…Here we report that the HPV16-positive BMK-16/myc cell treated with ovine IFN-τ, results in the activation of the canonical JAK-STAT and non-canonical JAK-STAT pathway. …”
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    Bovine Interferon-Tau Activates Type I interferon-Associated Janus-signal Transducer in HPV16-positive Tumor Cell
  11. 3971
    “…The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PTCH, SMO and GLI, whereas the noncanonical HH pathway involves the activation of SMO or GLI through other pathways. …”
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    The Role of Smoothened in Cancer
  12. 3972
    “…Interestingly, Wnt-mediated non-canonical planar cell polarity signaling was found to be a crucial regulator of myocardialization in the outlet septum and Wnt-mediated canonical β-catenin signaling is an essential regulator of the expansion of mesenchymal cells populating the outflow tract cushions.…”
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    Muscularization of the Mesenchymal Outlet Septum during Cardiac Development
  13. 3973
    por Bonchi, Filippo, Santamaria, Alessio
    Publicado 2021
    “…We describe the canonical weak distributive law [Formula: see text] of the powerset monad [Formula: see text] over the S-left-semimodule monad [Formula: see text] , for a class of semirings S. …”
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    Combining Semilattices and Semimodules
  14. 3974
    “…In this review, we focus on these non-canonical function of SET1 family members.…”
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    SET1/MLL family of proteins: functions beyond histone methylation
  15. 3975
    “…Here, we present evidence that during intramembranous bone formation OPC proliferation is controlled by Notch signaling, while differentiation is initiated by activation of canonical Wnt signaling. The temporospatial separation of Notch and Wnt signal activation during the early stages of bone regeneration suggests crosstalk between the two pathways. …”
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    Notch-Wnt signal crosstalk regulates proliferation and differentiation of osteoprogenitor cells during intramembranous bone healing
  16. 3976
    por Durgan, Joanne, Florey, Oliver
    Publicado 2021
    “…The identification of alternative Atg8-family protein PS lipidation opens up exciting new questions on the roles, regulation and biology of Atg8-family proteins during non-canonical autophagy.…”
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    A new flavor of cellular Atg8-family protein lipidation – alternative conjugation to phosphatidylserine during CASM
  17. 3977
    “…Monte Carlo computer simulations in the canonical and grand canonical statistical ensemble were used to explore the properties of the central force (CF1) water model. …”
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    Tetrahedrality, hydrogen bonding and the density anomaly of the central force water model. A Monte Carlo study*
  18. 3978
    “…Microglial dysfunction is mediated by the pro-inflammatory RELB/p52 non-canonical NF-κB transcriptional pathway and leads to excessive phagocytic clearance of neuronal material. …”
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    Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction
  19. 3979
    “…We develop hybrid pyrrolysyl tRNA variants to incorporate non-canonical amino acids in response to the quadruplet codon UAGA. …”
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    Using a quadruplet codon to expand the genetic code of an animal
  20. 3980
    “…The most stable structure of DNA is the canonical right-handed double helix termed B DNA. However, certain environments and sequence motifs favor alternative conformations, termed non-canonical secondary structures. …”
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    High-throughput techniques enable advances in the roles of DNA and RNA secondary structures in transcriptional and post-transcriptional gene regulation
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