Mostrando 381 - 400 Resultados de 23,561 Para Buscar '"canonization"', tiempo de consulta: 0.34s Limitar resultados
  1. 381
    por Katoh, Masaru
    Publicado 2017
    “…WNT signaling cascades cross-talk with the FGF, Notch, Hedgehog and TGFβ/BMP signaling cascades and regulate expression of functional CSC markers, such as CD44, CD133 (PROM1), EPCAM and LGR5 (GPR49). Aberrant canonical and non-canonical WNT signaling in human malignancies, including breast, colorectal, gastric, lung, ovary, pancreatic, prostate and uterine cancers, leukemia and melanoma, are involved in CSC survival, bulk-tumor expansion and invasion/metastasis. …”
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  2. 382
    “…As part of this GOF, molecular mechanisms explaining the non-canonical function of TP53 gene abnormality have been reported, in which mutant p53 unconventionally binds with various critical molecules suppressing oncogenic properties, such as p63 and p73. …”
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  3. 383
  4. 384
    “…Here, we explore the roles of four conserved Pros in the glycine receptor (GlyR), creating substitutions with canonical and noncanonical amino acids, characterizing them using two electrode voltage clamp electrophysiology in Xenopus oocytes, and interpreting changes in receptor parameters using structural data from the open and closed states of the receptor. …”
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  5. 385
    “…Mechanistically, in vitro and/or in vivo studies demonstrated that morroniside could not only inhibit canonical and non-canonical NF-κB, inflammatory mediators (IL6, IL-1b, CRP, NIRP3, PTGS2, TNFα), but also down-regulate protein degradation signals (Follistatin, Myostatin, ALK4/5/7, Smad7/3), ubiquitin-proteasome molecules (FoxO3, Atrogin-1, MuRF1), autophagy-lysosomal molecules (Bnip3, LC3A, and LC3B), while promoting protein synthesis signals (IGF-1/IGF-1R/IRS-1/PI3K/Akt, and BMP14/BMPR2/ALK2/3/Smad5/9). …”
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  6. 386
    “…In vertebrate embryos, the canonical Wnt ligand primes the formation of dorsal organizers that govern dorsal-ventral patterns by secreting BMP antagonists. …”
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  7. 387
    “…Gα(q)-coupled receptor stimulation was implied in the activation process of transient receptor potential canonical (TRPC)1/4 and TRPC1/5 heterotetrameric channels. …”
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  8. 388
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  10. 390
    por Meessen, P
    Publicado 2006
    “…It is shown that a homogeneous Lorentzian space for which every null- geodesic is canonically homogeneous, admits a non-vanishing homogeneous Lorentzian structure belonging to the class T/sub 1 /circled +T/sub 3/.…”
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  11. 391
  12. 392
    por Bojowald, Martin
    Publicado 2011
    “…The first systematic explanation of canonical methods in gravity for graduate students and researchers.…”
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