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Mostrando 461 - 480 Resultados de 23,561 Para Buscar '"canonization"', tiempo de consulta: 0.30s Limitar resultados
  1. 461
    “…Notch signalling is a causal determinant of cancer and efforts have been made to develop targeted therapies to inhibit the so-called canonical pathway. Here we describe an unexpected pro-apoptotic role of Notch3 in regulating tumour angiogenesis independently of the Notch canonical pathway. …”
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    Non-canonical NOTCH3 signalling limits tumour angiogenesis
  2. 462
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    Non-canonical dorsoventral patterning in the moth midge Clogmia albipunctata
  3. 463
    “…Major cognitive functions such as language, memory, and decision-making are thought to rely on distributed networks of a large number of basic elements, called canonical microcircuits. In this theoretical study we propose a novel canonical microcircuit model and find that it supports two basic computational operations: a gating mechanism and working memory. …”
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    A model of individualized canonical microcircuits supporting cognitive operations
  4. 464
    “…In this review, we will focus on the diverse functions of the canonical Wnt signaling pathway on the developmental processes preceding embryo implantation, as well as on its roles in pluripotent stem cell biology such as self-renewal and cell cycle regulation and somatic cell reprogramming.…”
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    The Pleiotropic Effects of the Canonical Wnt Pathway in Early Development and Pluripotency
  5. 465
    “…Here we show that the Arabidopsis canonical E2Fs, including E2Fa, E2Fb, and E2Fc, play a redundant role in plant germline development. …”
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    The Canonical E2Fs Are Required for Germline Development in Arabidopsis
  6. 466
    “…Third, reactivating canonical Wnt signaling enhances the function of both murine and human ISCs and, thus, ameliorates aging-associated phenotypes of ISCs in an organoid assay. …”
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    Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells
  7. 467
    “…Here, we report the unexpected finding that protein arginine methyltransferase 1 (PRMT1) is required for canonical Wnt signaling. Treatment of cultured cells for 5–30 min with Wnt3a induced a large increase in total endocytic vesicles which were also positive for asymmetric dimethylarginine modifications. …”
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    Arginine methylation is required for canonical Wnt signaling and endolysosomal trafficking
  8. 468
    “…Our analysis showed that the I–U pairs induce changes in base pair and base pair step parameters and have different dynamics when compared with standard canonical base pairs. In particular, the first I–U pair from tandem I–U/I–U systems exhibited increased dynamics depending on its neighboring 5′ base. …”
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    Role of Inosine–Uracil Base Pairs in the Canonical RNA Duplexes
  9. 469
    por Huangyang, Peiwei, Simon, M. Celeste
    Publicado 2018
    “…Understanding their non-canonical properties should enhance the development of new therapeutic strategies for cancer treatment.…”
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    Hidden features: exploring the non-canonical functions of metabolic enzymes
  10. 470
    “…Recent in vivo studies reported that loss of canonical Wnt signaling exacerbates amyloid deposition in a transgenic (Tg) mouse model of AD. …”
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    Loss of canonical Wnt signaling is involved in the pathogenesis of Alzheimer's disease
  11. 471
    “…In this review, we introduce how these molecules and non-canonical Wnt signaling regulate the bone-resorbing activity of osteoclasts.…”
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    Non-canonical Wnt signals regulate cytoskeletal remodeling in osteoclasts
  12. 472
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    Publisher Correction: Non-canonical nucleosides and chemistry of the emergence of life
  13. 473
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    The Preferable Binding Pose of Canonical Butyrylcholinesterase Substrates Is Unproductive for Echothiophate
  14. 474
    “…MOTIVATION: Canonical forms of the antibody complementarity-determining regions (CDRs) were first described in 1987 and have been redefined on multiple occasions since. …”
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    SCALOP: sequence-based antibody canonical loop structure annotation
  15. 475
    “…We discuss a canonical structure that provides a unifying description of dynamical large deviations for irreversible finite state Markov chains (continuous time), Onsager theory, and Macroscopic Fluctuation Theory (MFT). …”
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    Canonical Structure and Orthogonality of Forces and Currents in Irreversible Markov Chains
  16. 476
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    Non-canonical transcriptional regulation of heme oxygenase in Aedes aegypti
  17. 477
    “…Canonical WNT/β-catenin signaling is involved in most of the mechanisms that lead to the formation and development of cancer cells. …”
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    Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers
  18. 478
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    Untargeted Metabolomics to Go beyond the Canonical Effect of Acetylsalicylic Acid
  19. 479
    “…Here, we engineered rodent Plasmodium berghei to express a minimal, non-canonical RNAi machinery that solely requires Argonaute 2 (Ago2) and a modified short hairpin RNA, so-called AgoshRNA. …”
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    Gene knockdown in malaria parasites via non-canonical RNAi
  20. 480
    “…Further studies are warranted to evaluate the clinical significance of canonical HH signaling in canine OSA.…”
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    Evaluation of canonical Hedgehog signaling pathway inhibition in canine osteosarcoma
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